PPIs Are the Most Effective Drugs to Reduce Risk for Upper GI Bleeding
Gastroenterology Summary and Comment
Proton-pump inhibitors bested histamine-2–receptor antagonists and nitrates in patients taking gastrotoxic drugs and in the general population.
Helicobacter pylori Therapy in Latin America: Triple-Drug Regimen Still Best
Gastroenterology Summary and Comment
Standard 14-day triple-drug therapy — despite its suboptimal eradication rate — was more effective than shorter-duration concomitant or sequential four-drug regimens.
Which Scoring System Best Predicts Outcomes of Upper Gastrointestinal Bleeding?
Gastroenterology Summary and Comment
Glasgow-Blatchford and Rockall scores were similarly effective, but comparing systems is less important than using some method to identify which patients need early and vigorous therapy.
Nonadherence to Gastroprotective Therapy Among NSAID Users
Gastroenterology Summary and Comment
Low adherence increased risk for upper gastrointestinal bleeding.
PPI Cotherapy Is Cost-Effective in Patients Taking Aspirin
Gastroenterology Summary and Comment
Cotherapy with a proton-pump inhibitor and aspirin produced better gastrointestinal and cardiovascular outcomes than aspirin alone and was cost-effective in all age groups.
New Asia-Specific Guidelines for Nonvariceal Upper Gastrointestinal Bleeding
Gastroenterology Summary and Comment
Recommendations take into account varying healthcare resources and the epidemiology of gastrointestinal disease in Asian and Pacific countries.
Are We Diagnosing Eosinophilic Esophagitis Consistently?
Gastroenterology Summary and Comment
Despite 2007 published guidelines, use of variable diagnostic criteria persists.
By David A. Johnson, MD
July 15, 2011
Covering:
Sperry SLW et al., Am J Gastroenterol 2011 May; 106:824
Angiographic Embolization Might Work for Recurrent Ulcer Bleeding
Gastroenterology Summary and Comment
In a retrospective study, embolization was an acceptable alternative to surgery after failed endoscopic therapy.
Functional Dyspepsia Linked to Disordered Sleep
Gastroenterology Summary and Comment
But, the nature of the association remains unclear.
Do PPIs Interfere with Aspirin's Antiplatelet Effect?
General Medicine Summary and Comment
Cardiovascular risk was higher in myocardial infarction patients who received proton-pump inhibitors along with aspirin.
Use of Proton-Pump Inhibitors in Infants and Children
PPIs are not effective in infants, but this analysis suggests that a trial of PPIs might be warranted in children and adolescents with gastroesophageal reflux.
By Howard Bauchner, MD
May 4, 2011
Covering:
van der Pol RJ et al., Pediatrics 2011 May; 127:925
Long-Term Proton-Pump Inhibitor Therapy in Children
Gastroenterology Summary and Comment
Free
A high percentage of children developed low-grade enterochromaffin cell-like hyperplasia.
Looking for Reflux with MII: How Useful Is It?
Multichannel intraluminal impedance results rarely changed management decisions.
Esophageal Adenocarcinoma in Populations with Gastroesophageal Reflux Disease
Gastroenterology Summary and Comment
Incidence of EAC in patients with GERD was very low overall, especially among men younger than 50 and women at any age.
By David A. Johnson, MD
April 22, 2011
Covering:
Rubenstein JH et al., Am J Gastroenterol 2011 Feb; 106:254
Shaheen NJ., Am J Gastroenterol 2011 Feb; 106:261
Does Clopidogrel Reduce the Effectiveness of Proton-Pump Inhibitors?
Gastroenterology Summary and Comment
Free
In patients receiving clopidogrel for atherosclerosis, esomeprazole was effective in reducing peptic ulcer recurrence.
Clopidogrel and Proton-Pump Inhibitors after Myocardial Infarction
Gastroenterology Summary and Comment
PPI use was not associated with excess risk for adverse cardiovascular events or mortality in clopidogrel-treated patients, regardless of their CYP2C19 genotype.
Helicobacter pylori Infection and Peptic Ulcer Disease in a Rural Area of the U.S.
Infectious Diseases Summary and Comment
A retrospective analysis showed significant declines in the rates of <$EMPH_O>H. pylori<$EMPH_C> infection and peptic ulcer disease between 1993–1998 and 2004–2009.
By Neil M. Ampel, MD
March 23, 2011
Covering:
McJunkin B et al., Am J Med 2011 Mar; 124:260
Another Study of PPIs plus Clopidogrel
General Medicine Summary and Comment
The proton-pump inhibitor esomeprazole prevented recurrent ulcers in clopidogrel-treated patients.
By Allan S. Brett, MD
March 22, 2011
Covering:
Hsu P-I et al., Gastroenterology 2011 Mar; 140:791
Pre-Endoscopy Erythromycin for Variceal Bleeding
Gastroenterology Summary and Comment
Free
Intravenous erythromycin reduced the amount of blood in the stomach for patients undergoing endoscopic therapy for variceal lesions.
Zinc Inhibits Gastric Acid Secretion
Gastroenterology Summary and Comment
Short-term outcomes of increased pH and decreased acid secretion support zinc's potential use in treatment regimens for gastroesophageal reflux disease.
Helicobacter pylori Eradication and Body-Mass Index
Gastroenterology Summary and Comment
BMI increased after eradication therapy, but the clinical significance is questionable.
Quadruple Therapy for Helicobacter pylori Infection
Gastroenterology Summary and Comment
Free
A combination of bismuth subcitrate potassium, metronidazole, tetracycline, and omeprazole was safe and effective at eradicating <$EMPH_O>H. pylori<$EMPH_C> infection.
Computerized Prediction of Mortality from Upper Gastrointestinal Bleeding
Gastroenterology Summary and Comment
An artificial neural-network program that used pre-endoscopy data was superior to the Rockall scoring system.
Quadruple Therapy for Eradicating H. pylori Infections
General Medicine Summary and Comment
Bismuth-based quadruple therapy bested a standard triple-therapy regimen.
By Bruce Soloway, MD
March 3, 2011
Covering:
Malfertheiner P et al., Lancet 2011 Feb 22
Clopidogrel, Proton-Pump Inhibitors, and Cardiovascular Events
Gastroenterology Summary and Comment
Free
A careful analysis of drug exposure after coronary stent implantation found no significant association between major cardiovascular events and concomitant use of clopidogrel and PPIs.
