Ablative Reversal of Barrett Esophagus to Reduce Cancer Risk
Gastroenterology Summary and Comment
Free
Questions remain to be answered before ablative therapy is put into practice.
By David A. Johnson MD
November 17, 2006
Covering:
Sharma P et al., Gut 2006 Sep; 55:1233-9
PPIs or H2 -Antagonists to Prevent Peptic Ulcer Rebleeding?
Gastroenterology Summary and Comment
In contrast to earlier Asian studies, this small U.S. trial did not show a significant difference between IV PPIs and IV H2 -antagonists for preventing rebleeding.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
November 17, 2006
Covering:
Jensen DM et al., Am J Gastroenterol 2006 Sep; 101:1991-9
GERD in Women
Clinical picture and management of this common gastrointestinal disease
By Philip O. Katz, MD, and Jenifer K. Lehrer, MD
November 16, 2006
Burning to Know About GERD?
Women's Health Patient Information
Diagnosis and treatment of this common gastrointestinal disorder
By Diane E. Judge, APN/CNP
November 16, 2006
Presentation of Reflux Esophagitis in the Elderly
General Medicine Summary and Comment
Elderly patients are less likely than their younger counterparts to present with classic symptoms.
By Allan S. Brett, MD
November 9, 2006
Covering:
Pilotto A et al., J Am Geriatr Soc 2006 Oct; 54:1537-42
Cost-Effectiveness of PPIs for Peptic Ulcer Hemorrhage
Gastroenterology Summary and Comment
IV PPIs might be less cost-effective than oral PPIs for ulcer patients.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
November 3, 2006
Covering:
Spiegel BM et al., Clin Gastroenterol Hepatol 2006 Aug; 4:988-97
Bleeding Risk with Low-Dose Aspirin and with Clopidogrel
Neurology Summary and Comment
Free
Risk for bleeding with low-dose aspirin was low in this meta-analysis, which lacked sufficient data to allow conclusions to be drawn about risk for bleeding with clopidogrel versus aspirin.
By Eric Cheng, MD, MS, and Barbara Vickrey, MD, MPH
October 31, 2006
Covering:
McQuaid KR and Laine L., Am J Med 2006 Aug; 119:624-38
GERD Symptoms Linked to Cardiac Dysrhythmias
Gastroenterology Summary and Comment
Extra-esophageal complications can go beyond noncardiac chest pain.
By David A. Johnson, MD
September 29, 2006
Covering:
Cuomo R et al., Aliment Pharmacol Ther 2006 Jul 15; 24:361-70
PPIs for Laryngeal Symptoms: Two More Negative Trials
General Medicine Summary and Comment
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PPIs weren't beneficial for chronic laryngeal symptoms, laryngoscopic findings appeared to be nonspecific, and pH abnormalities didn’t predict treatment response.
By Allan S. Brett, MD
September 28, 2006
Covering:
Wo JM et al., Am J Gastroenterol 2006 Sep; 101:1972-8
Vaezi MF et al., Laryngoscope 2006 Feb; 116:254-60
Esomeprazole Minimally Effective in Functional Dyspepsia
General Medicine Summary and Comment
There was transient symptom relief with esomeprazole at 4 weeks, but the difference was no longer significant at 8 weeks.
By Allan S. Brett, MD
September 28, 2006
Covering:
van Zanten SV et al., Am J Gastroenterol 2006 Sep; 101:2096-106
Effect of CagA Status on H. pylori Eradication
Gastroenterology Summary and Comment
In this meta-analysis, pooled eradication rates were significantly higher for CagA-positive strains than for CagA-negative strains.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
September 22, 2006
Covering:
Suzuki T et al., Aliment Pharmacol Ther 2006 Jul 15; 24:273-80
PPI Therapy Before Endoscopy Aids Detection of BE
Gastroenterology Summary and Comment
Treating for erosive esophagitis before performing endoscopy improves accuracy of screening for Barrett esophagus.
By David A. Johnson, MD
September 15, 2006
Covering:
Hanna S et al., Am J Gastroenterol 2006 Jul; 101:1416-20
Changes in Peptic Ulcer Demographics in Scotland
Gastroenterology Summary and Comment
Hospitalization rates for complicated ulcer are dropping, but the decline is faster for young adults than for elders.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
September 15, 2006
Covering:
Kang JY et al., Aliment Pharmacol Ther 2006 Jul 1; 24:65-79
H. pylori Eradication and Precancerous Gastric Lesions
General Medicine Summary and Comment
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Amoxicillin plus omeprazole appears to slow the progression of histologic abnormalities, but a reduced incidence of gastric cancer remains unproved.
By Allan S. Brett, MD
August 8, 2006
Covering:
You W-C et al., J Natl Cancer Inst 2006 Jul 19; 98:974-83
Endoscopic Ulcers in Patients Taking Low-Dose Aspirin and NSAIDs
Gastroenterology Summary and Comment
In a 7-day randomized trial, concomitant use of aspirin and NSAIDs, whether selective or nonselective, significantly increased ulcer risk.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
July 28, 2006
Covering:
Goldstein JL et al., Aliment Pharmacol Ther 2006 May 15; 23:1489-98
Controlling Acid Likely Will Control Laryngeal Injury
Gastroenterology Summary and Comment
Therapy for GERD-associated laryngopharyngeal reflux should focus on acid suppression.
By David A. Johnson, MD
August 11, 2006
Covering:
Roh JL et al., Am J Gastroenterol 2006 Jun; 101:1186-92
GERD and Quality of Life
Gastroenterology Summary and Comment
Free
Even weekly GERD symptoms can negatively affect quality of life.
By David A. Johnson, MD
August 4, 2006
Covering:
Ronkainen J et al., Aliment Pharmacol Ther 2006 Jun 15; 23:1725-33
Gain Weight — Get GERD
Women's Health Summary and Comment
Increases in BMI are associated with increased risk for frequent symptoms of GERD, even among women of normal weight.
By Andrew M. Kaunitz, MD
June 30, 2006
Covering:
Jacobson BC et al., N Engl J Med 2006 Jun 1; 354:2340-8
BMI and GERD in Women
Gastroenterology Summary and Comment
Risk for GERD appears to be directly linked to BMI, even among normal-weight individuals.
By David A. Johnson, MD
June 13, 2006
Covering:
Jacobson BC et al., N Engl J Med 2006 Jun 1; 354:2340-8
Do Lifestyle Changes Improve GERD Outcomes?
Gastroenterology Summary and Comment
Little evidence is available to support the effect of lifestyle changes on symptoms of reflux.
By David A. Johnson, MD
June 13, 2006
Covering:
Kaltenbach T et al., Arch Intern Med 2006 May 8; 166:965-71
The Changing Epidemiology of Peptic Ulcer Disease
Gastroenterology Summary and Comment
From 1993 through 2002, the overall incidence of peptic ulcers decreased in Denmark, but the incidence of bleeding ulcers was unchanged.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
June 27, 2006
Covering:
Lassen A et al., Am J Gastroenterol 2006 May; 101:945-53
Surgical Fundoplication for Suspected Laryngopharyngeal Reflux
Gastroenterology Summary and Comment
Free
Antireflux surgery has little, if any, benefit for patients with suspected GERD who do not respond to aggressive PPI therapy.
By David A. Johnson, MD
May 30, 2006
Covering:
Swoger J et al., Clin Gastroenterol Hepatol 2006 Apr; 4:433-41
Spechler SJ., Clin Gastroenterol Hepatol 2006 Apr; 4:431-2
Supplemental Use of H2 -Receptor Antagonists in Patients Who Take Daily PPIs
Gastroenterology Summary and Comment
Trial data do not support the use of H2 -receptor antagonists in patients taking daily PPIs.
By David A. Johnson MD
May 30, 2006
Covering:
Vakil N et al., Aliment Pharmacol Ther 2006 Mar 1; 23:649-53
Minimizing Risk for Aspirin-Associated GI Complications in CVD Patients
Gastroenterology Summary and Comment
Free
Most patients who receive aspirin for cardioprotection are at risk for aspirin-associated GI complications, but only about 25% receive PPIs or misoprostol to reduce this risk.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
May 9, 2006
Covering:
Targownik LE and Al-Mamfud A., Aliment Pharmacol Ther 2006 Mar 15; 23:743-9
Combined Injection and PPI Therapy for Bleeding Ulcers
Gastroenterology Summary and Comment
Epinephrine injection plus high-dose omeprazole therapy was superior to injection plus cimetidine therapy for preventing ulcer rebleeding.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
May 9, 2006
Covering:
Lin HJ et al., Am J Gastroenterol 2006 Mar; 101:500-5
