Cognitive Decline After Sepsis Hospitalization
Neurology Summary and Comment
Free
Older patients hospitalized with severe sepsis are at increased risk for new cognitive deficits and functional impairment, highlighting their need for subacute and chronic follow-up.
Social Factors Predict Excess Risk for Antenatal Depression
Women's Health Summary and Comment
Intimate partner violence, chronic medical conditions, and black race or Latina ethnicity confer the greatest risks for antenatal depression, which affects 10% of women.
By Wendy S. Biggs, MD
November 18, 2010
Covering:
Melville JL et al., Obstet Gynecol 2010 Nov; 116:1064
SSRIs as a Treatment for Psychogenic Nonepileptic Seizures?
Neurology Summary and Comment
A pilot study of sertraline supports further investigation of selective serotonin reuptake inhibitors for PNES.
Tricyclics Lighten Headache Burden in Patients with Migraine and Tension Headaches
General Medicine Summary and Comment
Free
Tricyclics are more effective than selective serotonin reuptake inhibitors.
Does Injectable Contraception Contribute to Postpartum Depression?
Women's Health Summary and Comment
A retrospective cohort study of midwestern postpartum women suggests it does not.
By Andrew M. Kaunitz, MD
August 26, 2010
Covering:
Tsai R and Schaffir J., Contraception 2010 Aug; 82:174
Does Spousal Deployment Affect Risk for Depression During Pregnancy or Postpartum in Military Wives?
Women's Health Summary and Comment
Women with spouses at all stages of deployment were at risk for depression.
Does Depression Predict Physical Function in Coronary Artery Disease, or Vice Versa?
General Medicine Summary and Comment
Depression appears to come first, especially in patients without heart failure.
By Thomas L. Schwenk, MD
November 2, 2010
Covering:
Kendel F et al., Arch Intern Med 2010 Oct 25; 170:1717
How Does Education Protect Against Dementia?
Neurology Summary and Comment
This study confirms that higher level of education is associated with a lower incidence of clinical dementia but not reduced pathology.
By Howard S. Kirshner, MD
September 28, 2010
Covering:
EClipSE Collaborative Members., Brain 2010 Aug; 133:2210
Redefining Alzheimer Disease
Neurology Summary and Comment
Free
An ad hoc international working group proposes a new lexicon, to be used in both clinical and research settings, that defines AD on a continuum.
Is Prenatal Exposure to Organophosphate Pesticides Associated with Attention-Deficit/Hyperactivity Disorder?
Maternal prenatal pesticide levels were associated with attention problems in 5-year-old boys.
By Martin T. Stein, MD
September 15, 2010
Covering:
Marks AR et al., Environ Health Perspect 2010 Aug 19
Milnacipran for Fibromyalgia
General Medicine Summary and Comment
Efficacy is modest, and side effects are common.
By Allan S. Brett, MD
September 21, 2010
Covering:
Arnold LM et al., Arthritis Rheum 2010 Sep; 62:2745
Autism and Thimerosal Exposure: No Relation Found Again!
This study adds to the growing body of evidence demonstrating no association between prenatal or infant exposure to thimerosal and autism.
By Howard Bauchner, MD
September 29, 2010
Covering:
Price CS et al., Pediatrics 2010 Oct; 126:656
How Deadly Is Delirium in Elders?
Emergency Medicine Summary and Comment
Delirium was an independent predictor of 6-month mortality among older emergency department patients.
Adult Sleep Quality After Childhood Adversity
Neurology Summary and Comment
Among respondents to a large epidemiological survey, those who recalled more adverse experiences during childhood reported relatively worse sleep during adulthood.
By Quentin Regestein, MD
August 10, 2010
Covering:
Koskenvuo K et al., Sleep Med 2010 Jan; 11:17
Emotional Response to Bullying Is in the Genes
Variation in the serotonin transporter gene influences variability in response to being bullied.
By Martin T. Stein, MD
September 1, 2010
Covering:
Sugden K et al., J Am Acad Child Adolesc Psychiatry 2010 Aug; 49:830
Can Brief Emergency Department Interventions Reduce Teen Violence and Alcohol Use?
A brief intervention delivered by therapists reduced some self-reported violence- and alcohol-related outcomes.
By F. Bruder Stapleton, MD
August 18, 2010
Covering:
Walton MA et al., JAMA 2010 Aug 4; 304:527
Saitz R and Naimi TS., JAMA 2010 Aug 4; 304:575
Caregiver Support and Functional Improvement in Dementia Patients
General Medicine Summary and Comment
Structured home-based intervention improves some outcomes for both caregivers and patients.
Survival After Diagnosis of Dementia in Primary Care
General Medicine Summary and Comment
Survival time is much shorter when diagnoses occur in general practice than when patients are screened.
Information from Prescription Monitoring Programs Changes Opioid Prescribing Behavior
Emergency Medicine Summary and Comment
After reviewing past prescriptions, emergency physicians changed opioid prescribing plans for 41% of patients.
Outcomes of Drug Trials and Association with Funding Source
General Medicine Summary and Comment
Industry-funded trials were more likely to report positive outcomes.
Tai Chi Relieves Symptoms of Fibromyalgia
General Medicine Summary and Comment
Initial single-center results are encouraging, but verification is needed.
By Anthony L. Komaroff, MD
August 19, 2010
Covering:
Wang C et al., N Engl J Med 2010 Aug 19; 363:743
Yeh GY et al., N Engl J Med 2010 Aug 19; 363:783
New Therapeutic Target for Alzheimer Disease
General Medicine Summary and Comment
SIRT1 suppresses production of Aβ plaques.
By Anthony L. Komaroff, MD
August 17, 2010
Covering:
Donmez G et al., Cell 2010 Jul 23; 142:320
Wolfe MS and Selkoe DJ., Cell 2010 Jul 23; 142:194
Does Thyroxine Replacement Improve Cognition in Subclinical Hypothyroidism?
General Medicine Summary and Comment
Cognition scores did not improve in older patients who received thyroxine.
By Allan S. Brett, MD
August 19, 2010
Covering:
Parle J et al., J Clin Endocrinol Metab 2010 Aug; 95:3623
Spinal Fluid Markers Predict Progression to Alzheimer Disease
General Medicine Summary and Comment
Levels of two proteins that have long been associated with AD might be useful predictors.
What Is the Yield of Brain Biopsy in Patients with Neurological Decline?
General Medicine Summary and Comment
Brain biopsy established diagnoses in 18 of 51 cases but changed management in only 4 cases.
By Allan S. Brett, MD
August 12, 2010
Covering:
Schuette AJ et al., Neurology 2010 Aug 3; 75:419
