More Data on Fracture Risk with Thiazolidinediones
General Medicine
Summary and Comment
Risk was particularly elevated among older women.
By Allan S. Brett, MD
March 2, 2010
Covering:
Habib ZA et al., J Clin Endocrinol Metab 2010 Feb; 95:592
Metformin and Vitamin B12 Deficiency
General Medicine
Summary and Comment
Free
Evidence suggests that metformin lowers vitamin B12 levels in patients with diabetes.
By Allan S. Brett, MD
February 25, 2010
Covering:
Wile DJ and Toth C., Diabetes Care 2010 Jan; 33:156
Maternal Diabetes, Not Obesity, Does the Damage
Women's Health
Summary and Comment
Free
Pregestational diabetes was associated significantly with congenital anomalies; obesity alone was not.
By Wendy S. Biggs, MD
February 25, 2010
Covering:
Biggio JR Jr et al., Obstet Gynecol 2010 Feb; 115:290
Obesity in America: How High Can It Go?
Cardiology
Summary and Comment
One third of U.S. adults are obese, and the latest population-level data indicate no reversal of the upward trend.
By Harlan M. Krumholz, MD, SM
February 17, 2010
Covering:
Flegal KM et al., JAMA 2010 Jan 20; 303:235
Gaziano JM., JAMA 2010 Jan 20; 303:275
Childhood Obesity, Glucose Intolerance, and Hypertension Increase Risk for Premature Adult Mortality
A possible association between childhood obesity and premature death might be partially mediated by childhood glucose intolerance and hypertension.
Cultural Competence Training Isn't Associated with Better Diabetes Outcomes
General Medicine
Summary and Comment
Awareness of racial disparities didn't translate into better glucose, lipid, or blood pressure control.
Septic Shock, Insulin, and Steroids — Revisited
General Medicine
Summary and Comment
Free
Intensive insulin therapy did not lower in-hospital mortality in septic shock patients who received hydrocortisone.
By Allan S. Brett, MD
February 4, 2010
Covering:
The COIITSS Study Investigators., JAMA 2010 Jan 27; 303:341
Van den Berghe G., JAMA 2010 Jan 27; 303:365
Smoking Cessation and Risk for Type 2 Diabetes
General Medicine
Summary and Comment
Excess diabetes risk in quitters is mediated partially by weight gain.
Physical Activity, BMI, and Diabetes Risk in the Physicians' Health Study
General Medicine
Summary and Comment
Exercise lowered diabetes risk, but obese patients benefited significantly only by exercising at least 5 times weekly.
Obstructive Sleep Apnea and Risk for Incident Type 2 Diabetes
General Medicine
Summary and Comment
Patients with severe sleep apnea were more likely to develop diabetes than were those with less-severe symptoms.
Cardiovascular Benefit of Glycemic Control Is Limited to Those with Low Comorbidity
General Medicine
Summary and Comment
Does an HbA1c level of 7% remain an appropriate goal?
Glyburide Outperformed Metformin in Treating Women with Gestational Diabetes
Women's Health
Summary and Comment
Free
Compared with glyburide, metformin was associated with doubled risk for poor glycemic control.
By Wendy S. Biggs, MD
January 14, 2010
Covering:
Moore LE et al., Obstet Gynecol 2010 Jan; 115:55
Diagnosing Pediatric Metabolic Syndrome Is Problematic
Characteristics of metabolic syndrome are not stable in children.
By Robin Drucker, MD
January 13, 2010
Covering:
Gustafson JK et al., J Clin Endocrinol Metab 2009 Dec; 94:4828
Reducing Blood Pressure Levels Effectively in Practice
Cardiology
Summary and Comment
Free
Two interventions each helped to modify this cardiovascular risk factor successfully, but staffing such programs would be costly.
By Frederick A. Masoudi, MD, MSPH
January 6, 2010
Covering:
Ma J et al., Arch Intern Med 2009 Nov 23; 169:1988
Carter BL et al., Arch Intern Med 2009 Nov 23; 169:1996
How to Stay Healthy
Psychiatry
Year in Review
Free
A few easy New Year's resolutions to improve or maintain the physical, cognitive, and mental health of ourselves and our patients
Diabetic Patients and Cardiac Risk: What Works, and What Doesn't?
General Medicine
Year in Review
Free
In randomized trials, researchers examined routine stress testing in asymptomatic patients and revascularization for patients with stable CAD.
Glucose Control Among Critically Ill Patients
General Medicine
Year in Review
Free
Aiming for very low blood glucose targets in ICU patients can lead to more harm than good.
Pathogenesis, Classification, and Treatment of Diabetic Polyneuropathy
Neurology
Summary and Comment
Free
An informative summary of the nomenclature, epidemiology, clinical presentation, differential diagnosis, mechanisms of action, and treatment options
By Barbara E. Shapiro, MD, PhD
December 22, 2009
Covering:
Rutkove SB., JAMA 2009 Oct 7; 302:1451
Psoriasis Is Common in Children
Dermatology
Summary and Comment
Free
Pediatric psoriasis was associated with increased rates of serious comorbidities.
By Mary Wu Chang, MD
December 18, 2009
Covering:
Augustin M et al., Br J Dermatol 2009 Nov 18
Acanthosis Nigricans Identifies Youth at Risk for Diabetes
Dermatology
Summary and Comment
Free
Often seen in obese youth, this condition could signal the presence of insulin resistance or more-advanced disease.
By Mary Wu Chang, MD
December 18, 2009
Covering:
Brickman WJ et al., J Pediatr 2010 Jan; 156:87
Lifestyle Intervention Can Prevent Diabetes Onset for at Least a Decade
General Medicine
Summary and Comment
Lifestyle changes slowed development of diabetes in a large cohort study.
By Bruce Soloway, MD
December 15, 2009
Covering:
Diabetes Prevention Program Research Group., Lancet 2009 Nov 14; 374:1677
Metabolic Syndrome in Male Relatives of Women with Polycystic Ovary Syndrome
Women's Health
Summary and Comment
Obesity accounts for high prevalence of metabolic syndrome in fathers and brothers of women with polycystic ovary syndrome.
By Robert W. Rebar, MD
December 10, 2009
Covering:
Coviello AD et al., J Clin Endocrinol Metab 2009 Nov; 94:4361
Diabetes, Depression, and Disease Control
Psychiatry
Summary and Comment
In patients with diabetes, depression is associated with reduced compliance with medical treatments and worse disease control.
By Joel Yager, MD
December 7, 2009
Covering:
Katon W et al., Psychosom Med 2009 Nov/Dec; 71:965
Aspirin Unproved for Primary Prevention of CV Events in Patients with Diabetes
General Medicine
Summary and Comment
Results question guideline recommendations for routine aspirin use.
By Paul S. Mueller, MD, MPH, FACP
November 24, 2009
Covering:
De Berardis G et al., BMJ 2009 Nov 6; 339:b4531
Haynes R et al., BMJ 2009 Nov 6; 339:b4596
Insulin vs. Oral Therapy for Newly Diagnosed Type 2 Diabetes
General Medicine
Summary and Comment
Fears of adverse effects from early insulin treatment are not necessarily warranted.
By Allan S. Brett, MD
November 24, 2009
Covering:
Lingvay I et al., Diabetes Care 2009 Oct; 32:1789