Time Trends for Mortality Among Patients with Early- vs. Late-Onset Type 1 Diabetes
General Medicine Summary and Comment
Early-onset patients are faring better, but late-onset patients are doing worse.
Each Lifestyle Factor Adds to Diabetes Risk
General Medicine Summary and Comment
Unsurprisingly, the strongest predictor was elevated body-mass index.
Perioperative Glycemic Control in Patients Undergoing CABG
General Medicine Summary and Comment
Among patients undergoing coronary artery bypass grafting, a target glucose level of 120–180 mg/dL was as good as 90–120 mg/dL, with less hypoglycemia.
By Allan S. Brett, MD
September 29, 2011
Covering:
Lazar HL et al., Ann Surg 2011 Sep; 254:458
Glucose Variability Affects Hemoglobin A1c
General Medicine Summary and Comment
At any given average glucose level, high variability results in higher glycosylated hemoglobin level.
By Allan S. Brett, MD
September 13, 2011
Covering:
Kuenen JC et al., Diabetes Care 2011 Aug; 34:1843
Intensive Glucose-Lowering Treatment Does Not Lower 5-Year Mortality
General Medicine Summary and Comment
In this meta-analysis, treatment did not lower risks for other adverse outcomes associated with type 2 diabetes.
Hemoglobin A1c Level vs. Diagnosis of Diabetes as a Predictor of Cardiovascular Risk
General Medicine Summary and Comment
Adding glycosylated hemoglobin measurement improved ability to predict cardiovascular risk, but the clinical implications are unclear.
A Potentially Treatable Form of Diabetic Neuropathy
Neurology Summary and Comment
Careful phenotyping identifies a painless diabetic motor neuropathy — a variant of diabetic lumbosacral radiculoplexus neuropathy (diabetic amyotrophy) — that may respond to immunotherapy.
A SNP for the Increased Risk for Diabetes in Schizophrenia
Psychiatry Summary and Comment
An allele that is frequently associated with diabetes risk is found to have elevated prevalence in schizophrenia patients.
By Steven Dubovsky, MD
July 25, 2011
Covering:
Hansen T et al., Biol Psychiatry 2011 Jul 1; 70:59
Risk for Diabetes Increases with Statin Dose
General Medicine Summary and Comment
Risk was highest with intensive-dose therapy.
Patients Taking Disease-Modifying Antirheumatic Drugs Also Developed Less New Diabetes
Dermatology Summary and Comment
Free
Decreased incidence was associated with TNF antagonists and hydroxychloroquine but not with methotrexate.
By Jeffrey P. Callen, MD
July 15, 2011
Covering:
Solomon DH et al., JAMA 2011 Jun 22/29; 305:2525
Bongartz T and Kudva Y., JAMA 2011 Jun 22/29; 305:2573
Pass on HbA1c for Detecting Diabetes in Adolescents
HbA1c did not perform as well as traditional measures for diagnosing diabetes mellitus in high-risk adolescents.
Intensified Early Treatment of Subclinical Diabetes: No Benefit at 5 Years
General Medicine Summary and Comment
Longer follow-up might reveal benefit.
By Bruce Soloway, MD
July 12, 2011
Covering:
Griffin SJ et al., Lancet 2011 Jul 9; 378:156
Preiss D and Sattar N., Lancet 2011 Jul 9; 378:106
Painless Diabetic Motor Neuropathy
General Medicine Summary and Comment
In this unusual condition, muscle weakness is more prominent than sensory symptoms.
By Allan S. Brett, MD
July 12, 2011
Covering:
Garces-Sanchez M et al., Ann Neurol 2011 Jun; 69:1043
Does the HbA1c Criterion for Prediabetes Predict Incident Diabetes?
General Medicine Summary and Comment
Free
Measuring both fasting glucose and glycosylated hemoglobin levels might be the best method.
By Bruce Soloway, MD
July 7, 2011
Covering:
Heianza Y et al., Lancet 2011 Jun 25
Misra A and Garg S., Lancet 2011 Jun 25
Adding Exercise to Diet in Early Type 2 Diabetes
General Medicine Summary and Comment
Brisk walking, added to intensive dietary intervention, did not result in additional lowering of glycosylated hemoglobin.
By Bruce Soloway, MD
July 7, 2011
Covering:
Andrews RC et al., Lancet 2011 Jun 25
Hu FB., Lancet 2011 Jun 25
Landmark Biomarker Studies Are Likely to Overstate Findings
Cardiology Summary and Comment
Results of frequently cited studies often differ markedly from those of meta-analyses or studies in larger populations.
By JoAnne M. Foody, MD
July 6, 2011
Covering:
Ioannidis JPA and Panagiotou OA., JAMA 2011 Jun 1; 305:2200
Bossuyt PMM., JAMA 2011 Jun 1; 305:2229
Predicting Fracture Risk in Patients with Type 2 Diabetes
General Medicine Summary and Comment
At similar bone-mineral densities, fracture risk was higher for diabetic patients.
Managing Obesity in Primary Care: The Challenge Continues
A multicomponent primary care obesity intervention for young children did not have a significant effect on body-mass index.
By Martin T. Stein, MD
May 25, 2011
Covering:
Taveras EM et al., Arch Pediatr Adolesc Med 2011 Apr 4
FDA Updates Risk Evaluation and Mitigation Strategy for Rosiglitazone
The FDA has updated the Risk Evaluation and Mitigation Strategy (REMS) for rosiglitazone to include a "restricted access and distribution program."
Clinicians and patients now...
France Suspends Use of Pioglitazone Based on 'Slight' Risk for Bladder Cancer
The antidiabetes drug pioglitazone (marketed in the U.S. as Actos) is to be taken off the market in France because of concerns over a "slightly...
FDA Reminds Clinicians of Liraglutide's Risks for Pancreatitis and Cancer
The FDA is reminding clinicians of the potential risks for pancreatitis and thyroid C-cell tumors associated with the antidiabetes drug liraglutide (brand name, Victoza...
Heart Groups Release 10 Performance Measures for Coronary Artery Disease and Hypertension
Ten performance measures for treating outpatients with coronary artery disease and hypertension have been updated by the American College of Cardiology, the American Heart Association...
Add-On Drugs Compared for Uncontrolled Type 2 Diabetes
In the treatment of type 2 diabetes not controlled by metformin and a sulfonylurea, no add-on drug has an obvious advantage over another, according...
Can We Delay Conversion from Mild Cognitive Impairment to Alzheimer Disease?
Psychiatry Summary and Comment
Control of vascular risk factors may lower the conversion rate.
Automated Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes
General Medicine Summary and Comment
The "artificial pancreas" improved glucose control.
