Does High HbA1c During Pregnancy Predict Postpartum Glucose Abnormalities?
Women's Health Summary and Comment
Patients with highest HbA1c at diagnosis of gestational diabetes mellitus were more likely to develop abnormal glucose tolerance after delivery.
Blood Glucose Self-Monitoring in Non-Insulin Treated Type 2 Diabetics
General Medicine Summary and Comment
Self-monitoring lowered HbA1c more than usual care, but the difference was clinically insignificant.
A New Kind of Insulin Secretagogue for Type 2 Diabetes
General Medicine Summary and Comment
TAK-875, a selective agonist of free fatty acid receptor 1, has shown initial promise against glimepiride and placebo in a phase II trial.
Metformin Associated with Lower Cancer Risk
General Medicine Summary and Comment
Free
Compared with sulfonylurea users, metformin users had a 10% lower incidence of cancer.
By Allan S. Brett, MD
February 23, 2012
Covering:
Ruiter R et al., Diabetes Care 2012 Jan; 35:119
Another Molecular Clue About Exercise's Power to Combat Obesity and Type 2 Diabetes
General Medicine Summary and Comment
Exercising muscle produces irisin, which converts calorie-storing white fat cells into calorie-burning brown fat cells.
Up All Night Eating? Here's Why
Psychiatry Summary and Comment
On seeing images of food, sleep-deprived men — regardless of their blood glucose levels — showed increased activation of a brain area involved in hunger motivation.
By Steven Dubovsky, MD
February 17, 2012
Covering:
Benedict C et al., J Clin Endocrinol Metab 2012 Jan 18
Once-Weekly Exenatide for Type 2 Diabetes
General Medicine Summary and Comment
Decreases in HbA1c and weight with exenatide were similar to those with metformin.
By Allan S. Brett, MD
February 16, 2012
Covering:
Russell-Jones D et al., Diabetes Care 2012 Feb; 35:252
GLP-1R Agonists Associated with Weight Loss in Overweight Patients
General Medicine Summary and Comment
The association held for patients with or without diabetes.
Management of Hyperglycemia in Noncritically Ill Hospitalized Patients
Hospital Medicine Clinical Practice Guideline Watch
Free
Consensus guideline from the Endocrine Society, the American Diabetes Association, the American Heart Association, the American Association of Diabetic Educators, the European Society of Endocrinology, and the Society of Hospital Medicine
Starting Insulin in Hospitalized Patients: What's the Optimal Dose?
Hospital Medicine Summary and Comment
In a study of noncritically ill patients, a dose of <0.6 units/kg seems to be the threshold to avoid hypoglycemia.
Can Exercise Prevent Gestational Diabetes?
Women's Health Summary and Comment
Trial results do not provide a clear answer.
Diabetes Risk Increased with Atypical Antipsychotics in Children
Psychiatry Summary and Comment
Free
Children who take these drugs or antidepressants require rigorous monitoring for diabetes, especially during the first 6 months of therapy.
By Barbara Geller, MD
January 9, 2012
Covering:
Andrade SE et al., Pediatrics 2011 Dec; 128:1135
Long-Term Follow-Up from a Landmark Diabetes Trial
General Medicine Summary and Comment
Free
A period of intensive glycemic control slowed the progression of renal impairment.
By Allan S. Brett, MD
January 5, 2012
Covering:
The DCCT/EDIC Research Group., N Engl J Med 2011 Dec 22; 365:2366
Revised Guidelines: Secondary Prevention and Risk Reduction in Patients with Atherosclerotic Disease
Cardiology Clinical Practice Guideline Watch
Free
New recommendations for cardiac rehabilitation and risk reduction are welcome, but updated guidance is lacking on lipid and blood pressure management.
By JoAnne M. Foody, MD
January 4, 2012
Covering:
Smith SC Jr et al., Circulation 2011 Nov 29; 124:2458
Are Diabetes Mellitus and Epilepsy Linked in Children?
Children with type 1 diabetes mellitus have much higher risk for epilepsy than children in the general population.
Treatment Response to Etanercept in Juvenile Idiopathic Arthritis
One third of patients had good responses, and one third had poor responses. Younger age was associated with good response, and female sex and systemic disease were associated with poor response.
Glycemic Control No Worse in Diabetic Patients Who Also Have Psychiatric Illness
Psychiatry Summary and Comment
Over 5 years, diabetics with or without serious mental illness had elevated glycosylated hemoglobin levels.
By Joel Yager, MD
December 5, 2011
Covering:
Brown CH et al., J Nerv Ment Dis 2011 Nov; 199:899
Patients with Diabetes and Prior Stroke Benefit from Thrombolytic Therapy for Treatment of Acute Stroke
Emergency Medicine Summary and Comment
Free
This finding will expand eligibility for thrombolysis in the U.S.
Individual vs. Group Interventions in Patients with Diabetes
General Medicine Summary and Comment
Individual interventions were more effective, but benefits were small.
By Thomas L. Schwenk, MD
October 27, 2011
Covering:
Weinger K et al., Arch Intern Med 2011 Oct 10
Sperl-Hillen J et al., Arch Intern Med 2011 Oct 10
Is Idiopathic Central Diabetes Insipidus Really Idiopathic?
An underlying etiology was later identified in nearly 40% of children initially diagnosed with idiopathic diabetes insipidus.
Briefly Noted
Associations of neurologic disorders with bullous pemphigoid and of disrupted glucose metabolism with porphyria cutanea tarda
Venous Blood Gas Electrolyte Levels Accurate for Diagnosis of DKA
Emergency Medicine Summary and Comment
Findings suggest that VBG electrolyte results can be used in lieu of serum chemistry panel results to diagnose diabetic ketoacidosis.
No Association Found Between Urinary BPA and Type 2 Diabetes
General Medicine Summary and Comment
New study calms some concerns about bisphenol A, widely used in plastic and metal containers for food and drink.
α-Lipoic Acid Is Ineffective for Diabetic Neuropathy
General Medicine Summary and Comment
Objective improvement was borderline, and symptom relief was nil.
By Allan S. Brett, MD
October 13, 2011
Covering:
Ziegler D et al., Diabetes Care 2011 Sep; 34:2054
Time Trends for Mortality Among Patients with Early- vs. Late-Onset Type 1 Diabetes
General Medicine Summary and Comment
Early-onset patients are faring better, but late-onset patients are doing worse.
