Pioglitazone Is Associated with Excess Risk for Bladder Cancer
General Medicine Summary and Comment
Free
Using pioglitazone for >2 years or exceeding a cumulative dose of 28,000 mg imparted the highest risk.
Hyperglycemia at Admission Is Associated with Excess Mortality Among Pneumonia Patients
General Medicine Summary and Comment
But, whether treating hyperglycemia lowers mortality risk is unknown.
Prediabetes Is Associated with Risk for Stroke
General Medicine Summary and Comment
Findings varied by definition of prediabetes.
Elevated Serum Uric Acid Predicts Metabolic Syndrome in Adolescents
Male adolescents with the highest uric acid levels at baseline were 6 times more likely to develop metabolic syndrome after 3 years than those with the lowest levels.
Does Insulin Therapy Prevent Adverse Cardiovascular Events in Early Diabetes?
General Medicine Summary and Comment
Insulin glargine conferred no benefit in a large randomized trial.
By Allan S. Brett, MD
June 12, 2012
Covering:
The ORIGIN Trial Investigators., N Engl J Med 2012 Jun 11
General Medicine Summary and Comment
In a large randomized trial, supplementation was ineffective.
By Allan S. Brett, MD
June 12, 2012
Covering:
The ORIGIN Trial Investigators., N Engl J Med 2012 Jun 11
A Genetic Predictor of Antipsychotic-Associated Weight Gain in Children and Adults
Psychiatry Summary and Comment
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Homozygosity for a minor-allele polymorphism was strongly associated with severe weight gain after 12 weeks of treatment with atypical antipsychotics.
By Barbara Geller, MD
June 4, 2012
Covering:
Malhotra AK et al., Arch Gen Psychiatry 2012 May 7
Potential Benefit of Interrupting Prolonged Sitting
General Medicine Summary and Comment
A few minutes of exercise hourly improved glucose metabolism.
By Allan S. Brett, MD
May 31, 2012
Covering:
Dunstan DW et al., Diabetes Care 2012 May; 35:976
Challenges in Glycemic Control for Adolescents with Type 2 Diabetes
Metformin plus rosiglitazone bested metformin monotherapy, but failure rates for all tested regimens were disappointingly high.
Effects of Thiazide Diuretics on Glucose Metabolism
Cardiology Summary and Comment
Two crossover studies confirm adverse effects of thiazide diuretics — but not of potassium-sparing diuretics or beta-blockers — on short-term glucose tolerance.
By Joel M. Gore, MD
May 23, 2012
Covering:
Stears AJ et al., Hypertension 2012 May; 59:934
Elliott WJ., Hypertension 2012 May; 59:911
No Sustained Benefits for a Self-Management Education Program for Diabetes
General Medicine Summary and Comment
Only health-belief scores remained above baseline 3 years after an educational intervention among patients with newly diagnosed type 2 diabetes.
Why Sleep Patterns Matter
General Medicine Summary and Comment
Prolonged experimental shortening or disruption of sleep led to a prediabetic condition.
New Ultralong-Acting Basal Insulin Lowers Risk for Overnight Hypoglycemia
General Medicine Summary and Comment
However, insulin degludec is not yet FDA-approved.
By Bruce Soloway, MD
May 1, 2012
Covering:
Heller S et al., Lancet 2012 Apr 21; 379:1489
Garber AJ et al., Lancet 2012 Apr 21; 379:1498
Peer Mentors and Financial Incentives to Improve Diabetes Control
General Medicine Summary and Comment
Glucose control improved significantly with mentoring.
Glycemic Control on the Wards
Hospital Medicine Summary and Comment
Intensive glucose control in non-critically ill hospitalized patients is associated with decreased risk for infection but a trend toward increased hypoglycemia.
Metformin Plus Insulin vs. Insulin Alone in Patients with Type 2 Diabetes
General Medicine Summary and Comment
Free
Combination therapy led to lower insulin doses and better glycemic control.
The Incremental Relation Between Fasting Glucose and Glycosylated Hemoglobin
General Medicine Summary and Comment
The relation is affected, in part, by the degree of fasting hyperglycemia and use of oral antidiabetes drugs.
By Allan S. Brett, MD
April 26, 2012
Covering:
Ramachandran A et al., Diabetes Care 2012 Apr; 35:749
Once-Weekly Exenatide: An 84-Week Study
General Medicine Summary and Comment
This agent was associated with less hypoglycemia and weight gain than was insulin glargine.
By Allan S. Brett, MD
April 26, 2012
Covering:
Diamant M et al., Diabetes Care 2012 Apr; 35:683
Early Data on a Novel Agent for Treating Patients with Type 2 Diabetes
General Medicine Summary and Comment
Reductions in HbA1c levels were modest with dapagliflozin.
Does Prediabetic Impaired Glucose Tolerance Cause Neuropathy?
General Medicine Summary and Comment
Not according to a new study.
By Allan S. Brett, MD
April 3, 2012
Covering:
Callaghan BC et al., Arch Neurol 2012 Mar; 69:339
Dyck PJ et al., Diabetes Care 2012 Mar; 35:584
How Much Does Metformin Lower HbA1c Level?
General Medicine Summary and Comment
On average, by about 1% more than various alternatives.
By Allan S. Brett, MD
April 3, 2012
Covering:
Hirst JA et al., Diabetes Care 2012 Feb; 35:446
Gliptins vs. the Alternatives for Type 2 Diabetes
General Medicine Summary and Comment
Free
Gliptins are less effective than metformin monotherapy; when used with metformin, they confer some advantages and some disadvantages compared with other combinations.
Lifestyle Change Improves Mobility in Patients with Type 2 Diabetes
General Medicine Summary and Comment
Better mobility was related more to weight loss than to better fitness.
High Intake of White Rice Associated with Excess Risk for Type 2 Diabetes
General Medicine Summary and Comment
This finding was particularly marked in Asian populations.
Bariatric Surgery as a Treatment for Type 2 Diabetes in Obese Patients
General Medicine Summary and Comment
Many patients achieved diabetic remission during the first 2 years of follow-up.
By Allan S. Brett, MD
March 26, 2012
Covering:
Schauer PR et al., N Engl J Med 2012 Mar 26
Mingrone G et al., N Engl J Med 2012 Mar 26
