Antihypertensive Drugs and Risk for Diabetes
General Medicine Summary and Comment
Free
Prospective data from three large cohorts add to the evidence that thiazide diuretics and ß-blockers can cause glucose intolerance.
By Allan S. Brett, MD
May 30, 2006
Covering:
Taylor EN et al., Diabetes Care 2006 May; 29:1065-70
Diabetic Women Receive Inadequate Contraceptive Counseling
General Medicine Summary and Comment
In a nationwide study, diabetic women were about half as likely as nondiabetic women to receive contraceptive counseling.
By Robert W. Rebar, MD
May 30, 2006
Covering:
Schwarz EB et al., Obstet Gynecol 2006 May; 107:1070-4
Association of Diabetes and Hypertension with Shock-Wave Lithotripsy
Trauma to the kidneys and pancreas may explain the finding of a long-term risk.
By F. Bruder Stapleton, MD
May 26, 2006
Covering:
Krambeck AE et al., J Urol 2006 May; 175:1742-7
Antihypertensive Drugs and Development of Diabetes in Blacks
General Medicine Summary and Comment
Ramipril was associated with significantly lower risk for diabetes than was metoprolol or amlodipine.
By Jamaluddin Moloo, MD, MPH
May 9, 2006
Covering:
Thornley-Brown D et al., Arch Intern Med 2006 Apr 10; 166:797-805
Metabolic Syndrome and Stroke Risk
Neurology Summary and Comment
Free
Metabolic syndrome is gaining recognition as an important independent risk factor for vascular disease and stroke.
By Richard T. Benson, MD, PhD
May 4, 2006
Covering:
Najarian RM et al., Arch Intern Med 2006 Jan 9; 166:106-11
Kwon H-M et al., Stroke 2006 Feb; 37:466-70
Metformin: An Option for Adolescents with Polycystic Ovary Syndrome
Results of this small study suggest that metformin is beneficial for treating PCOS in adolescents.
By M. Susan Jay, MD
April 7, 2006
Covering:
Bridger T et al., Arch Pediatr Adolesc Med 2006 Mar; 160:241-6
Normalizing Blood Glucose After Ischemic Stroke: Does It Improve Outcome?
Emergency Medicine Summary and Comment
The authors argue that glucose control improves outcome, but the study doesn’t meet the burden of proof.
By Diane M. Birnbaumer, MD, FACEP
March 28, 2006
Covering:
Gentile NT et al., Acad Emerg Med 2006 Feb; 13:174-80
Greater CHD Risk from Diabetes in Women Than Men
Cardiology Summary and Comment
Both sexes have increased risk for fatal heart disease when diabetes is present, but for women the risk is greater.
By Harlan M. Krumholz, MD, SM
March 23, 2006
Covering:
Huxley R et al., BMJ 2006 Jan 14; 332:73-6
Insulin Glargine vs. Rosiglitazone as Add-On Therapy in Type 2 Diabetes
General Medicine Summary and Comment
The two approaches yielded similar degrees of improvement in glycemic control in patients already taking metformin and a sulfonylurea.
By Allan S. Brett, MD
March 17, 2006
Covering:
Rosenstock J et al., Diabetes Care 2006 Mar; 29:554-9
Gatifloxacin Linked to Dysglycemia
Infectious Diseases Summary and Comment
Free
In older patients, gatifloxacin therapy is associated with an increased risk for hypo- and hyperglycemia requiring hospital care.
By Richard T. Ellison III, MD
March 10, 2006
Covering:
Park-Wyllie LY et al., N Engl J Med 2006 Mar 30
Intensive Insulin Therapy in the Medical ICU
Cardiology General Medicine
Intensive therapy reduced in-hospital mortality among patients with ICU stays of 3 days or more, but not in the entire study population.
By Allan S. Brett, MD
March 9, 2006
Covering:
Van den Berghe G et al., N Engl J Med 2006 Feb 2; 354:449-61
Malhotra A., N Engl J Med 2006 Feb 2; 354:516-8
Obesity in Middle Age Portends Poor Outcomes in Older Age
Cardiology Summary and Comment
Insights from the Chicago Heart Association Detection Project in Industry
By JoAnne M. Foody, MD
February 16, 2006
Covering:
Yan LL et al., JAMA 2006 Jan 11; 295:190-8
Metabolic Syndrome Predicts NAFLD
Gastroenterology Summary and Comment
Prospective data suggest that the metabolic syndrome significantly increases NAFLD risk, particularly among women.
By Atif Zaman, MD, MPH
February 14, 2006
Covering:
Hamaguchi M et al., Ann Intern Med 2005 Nov 15; 143:722-8
Intensive Insulin Therapy in the Medical ICU
General Medicine Summary and Comment
Free
Intensive therapy reduced in-hospital mortality among patients with ICU stays of 3 days or more, but not in the entire study population.
By Allan S. Brett, MD
February 10, 2006
Covering:
Van den Berghe G et al., N Engl J Med 2006 Feb 2; 354:449-61
Malhotra A., N Engl J Med 2006 Feb 2; 354:516-8
Adding Insulin Glargine in Type 2 Diabetes
Cardiology General Medicine
A single daily injection of insulin glargine, added to oral antidiabetic therapy, improves glycemic control substantially.
By Allan S. Brett, MD
February 9, 2006
Covering:
Kennedy L et al., Diabetes Care 2006 Jan; 29:1-8
Breast-Feeding Appears to Reduce Diabetes Risk
Women's Health Summary and Comment
Lactation has been associated with improved insulin sensitivity and glucose tolerance, suggesting that it may also reduce risk for type 2 diabetes. These researchers evaluated . . .
By Jane E. Corboy, MD
February 7, 2006
Covering:
Stuebe AM et al., JAMA 2005 Nov 23; 294:2601-10
Do Sulfonylureas Increase Mortality?
General Medicine Summary and Comment
Free
In a retrospective study, high-dose glyburide was associated with increased rates of both all-cause and cardiovascular mortality.
By Allan S. Brett, MD
February 3, 2006
Covering:
Simpson SH et al., CMAJ 2006 Jan 17; 174:169-74
Bell DSH., CMAJ 2006 Jan 17; 174:185-6
Tight Control of Diabetes and Cardiovascular Disease
Improved glycemic control early in life has long-term cardiovascular benefits.
By Howard Bauchner, MD
January 27, 2006
Covering:
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group., N Engl J Med 2005 Dec 22; 353:2643-53
Cefalu WT., N Engl J Med 2005 Dec 22; 353:2707-9
Adding Insulin Glargine in Type 2 Diabetes
General Medicine Summary and Comment
Free
A single daily injection of insulin glargine, added to oral antidiabetic therapy, improves glycemic control substantially.
By Allan S. Brett, MD
January 20, 2006
Covering:
Kennedy L et al., Diabetes Care 2006 Jan; 29:1-8
Fenofibrate Shows Little Cardiovascular Benefit in Diabetics
General Medicine Summary and Comment
Statins remain the treatment of choice for reducing cardiovascular morbidity in diabetics.
By Bruce Soloway, MD
January 17, 2006
Covering:
Keech A et al., Lancet 2005 Nov 26; 366:1849-61
Colhoun H., Lancet 2005 Nov 26; 366:1829-31
Does Diabetes Negate the Long-Term Advantage of Primary Angioplasty over Fibrinolysis in STEMI?
Cardiology Summary and Comment
A DANAMI-2 substudy suggests yes, but a definitive answer will require further trials.
By Joel M. Gore, MD
January 12, 2006
Covering:
Madsen MM et al. for the DANAMI-2 Investigators., Am J Cardiol 2005 Dec 1; 96:1469-75
Hyperglycemia and Mortality in the ICU
Cardiology General Medicine
Because the association between hyperglycemia and mortality in the ICU is not straightforward, intensive insulin therapy for ICU patients remains controversial.
By Allan S. Brett, MD
January 12, 2006
Covering:
Rady MY et al., Mayo Clin Proc 2005 Dec; 80:1558-67
Whitcomb BW et al., Crit Care Med 2005 Dec; 33:2772-7
Bellomo R and Egi M., Mayo Clin Proc 2005 Dec; 80:1546-8
Angus DC and Abraham E., Am J Respir Crit Care Med 2005 Dec 1; 172:1358-9
Insulin Administration Elevates Plasma A-ß Levels and CSF Inflammatory Markers
Neurology Summary and Comment
Hyperinsulinemia, even in the absence of diabetes, is a known risk factor for Alzheimer disease (AD), but the reasons are not well understood. Insulin may . . .
By R. Wesley Farris II, MD
January 12, 2006
Covering:
Fishel MA et al., Arch Neurol 2005 Oct; 62:1539-44
Glycemic Control and Macrovascular Complications in Type 1 Diabetes
General Medicine Summary and Comment
Free
Cardiovascular benefits of a 6-year intensive intervention continued during 11 more years of follow-up.
By Allan S. Brett, MD
January 6, 2006
Covering:
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group., N Engl J Med 2005 Dec 22; 353:2643-53
Cefalu WT., N Engl J Med 2005 Dec 22; 353:2707-9
Outcomes with Fenofibrate in Type 2 Diabetes
Cardiology Summary and Comment
Insights from the FIELD study
By Beat J. Meyer, MD
January 5, 2006
Covering:
The FIELD Study Investigators., Lancet 2005 Nov 26; 366:1849-61
Colhoun H., Lancet 2005 Nov 26; 366:1829-31
