Insulin-Induced Hypoglycemia and Mortality After Acute MI
Cardiology
Summary and Comment
Free
Observational data suggest that spontaneously occurring hypoglycemia is more ominous than hypoglycemia that occurs after insulin treatment.
Does Glucose Normalization Improve Outcomes After Acute MI?
Cardiology
Summary and Comment
Observational data suggest that it does, regardless of whether it is achieved with insulin treatment.
By Joel M. Gore, MD
April 29, 2009
Covering:
Kosiborod M et al., Arch Intern Med 2009 Mar 9; 169:438
Glucose, Heart Failure, and Mortality
Cardiology
Summary and Comment
In patients hospitalized with heart failure, unlike other cardiovascular disorders, elevated glucose levels at admission did not predict mortality.
By Joel M. Gore, MD
April 29, 2009
Covering:
Kosiborod M et al., Circulation 2009 Apr 14; 119:1899
Secondary Prevention of Cardiovascular Events in Daily Practice
Cardiology
Summary and Comment
A longitudinal analysis of cross-sectional study results reveals an urgent need for effective lifestyle management.
By Beat J. Meyer, MD
April 22, 2009
Covering:
Kotseva K et al., Lancet 2009 Mar 14; 373:929
Brekke M and Gjelsvik B., Lancet 2009 Mar 14; 373:873
Screening for Cardiac Disease in Asymptomatic Patients with Type 2 Diabetes
General Medicine
Summary and Comment
Free
Overall cardiac risk was relatively low, and screening was of no benefit.
Causes of Excess Mortality Associated with Low and High BMIs
General Medicine
Summary and Comment
For both sexes and all ages, 13-year overall mortality was lowest in people with baseline BMIs of 22.5–25 kg/m2 .
By Bruce Soloway, MD
April 21, 2009
Covering:
Whitlock G et al for the Prospective Studies Collaboration., Lancet 2009 Mar 28; 373:1083
Behavioral and Circadian Rhythms: Best to Be in Synch
Psychiatry
Summary and Comment
Misaligned cycles lead to adverse cardiometabolic consequences in this laboratory study.
By Jonathan Silver, MD
April 6, 2009
Covering:
Scheer FAJL et al., Proc Natl Acad Sci U S A 2009 Mar 17; 106:4453
Ramsey KM and Bass J., Proc Natl Acad Sci U S A 2009 Mar 17; 106:4069
Percutaneous Renal Nerve Ablation for Persistent Hypertension
Cardiology
Summary and Comment
A novel interventional approach appears on the scene.
By Harlan M. Krumholz, MD
March 30, 2009
Covering:
Krum H et al., Lancet 2009 Mar 30
Doumas M and Douma S., Lancet 2009 Mar 30
Diagnosing Diabetic Osteomyelitis: Needle Puncture vs. Bone Biopsy
Infectious Diseases
Summary and Comment
Needle puncture was easier to perform but did not reliably identify bone bacteria.
By Neil M. Ampel, MD
March 25, 2009
Covering:
Senneville E et al., Clin Infect Dis 2009 Apr 1; 48:888
Intensive Glucose Control Harms Critically Ill Patients
General Medicine
Summary and Comment
Free
More evidence that just keeping glucose levels <180 mg/dL is better than striving for very low levels.
By Paul S. Mueller, MD, MPH, FACP
March 24, 2009
Covering:
The NICE-SUGAR Study Investigators., N Engl J Med 2009 Mar 26; 360:1283
Inzucchi SE and Siegel MD., N Engl J Med 2009 Mar 26; 360:1346
Childhood Stresses Take a Toll on Adult Immune Health
Psychiatry
Summary and Comment
In a large records study, childhood adversity increases the risk for autoimmune disorders in adulthood.
By Joel Yager, MD
March 23, 2009
Covering:
Dube SR et al., Psychosom Med 2009 Feb; 71:243
Does Race Affect Risk for Early Heart Failure?
Cardiology
Summary and Comment
Findings from the CARDIA study reveal a much higher incidence of heart failure in young blacks than in young whites.
By Harlan M. Krumholz, MD, SM
March 18, 2009
Covering:
Bibbins-Domingo K et al., N Engl J Med 2009 Mar 19; 360:1179
Peterson E and Yancy CW., N Engl J Med 2009 Mar 19; 360:1172
Diabetes and Risk for Antenatal and Postpartum Depression
Women's Health
Summary and Comment
Perinatal depression was substantially more prevalent among women with diabetes than among those without.
By Wendy S. Biggs, MD
March 12, 2009
Covering:
Kozhimannil KB et al., JAMA 2009 Feb 25; 301:842
Intensive Glycemic Control in Pediatric Intensive Care
General Medicine
Summary and Comment
Controlling glucose to age-adjusted normal levels in a pediatric ICU resulted in better outcomes.
By Bruce Soloway, MD
March 10, 2009
Covering:
Vlasselaers D et al., Lancet 2009 Feb 14; 373:547
Emerging Perspectives: Diabetes and the Brain
Recent studies examine the importance of glucose to brain functioning in elders.
Diabetes, Depression, and Pregnancy
General Medicine
Summary and Comment
Free
Diabetes was associated with perinatal depression in low-income mothers.
Predictors of Early Stent Thrombosis
Cardiology
Summary and Comment
Among several disease-and procedure-related culprits, suboptimal antiplatelet use might be the easiest target for improving outcomes after stenting.
By Howard C. Herrmann, MD
February 25, 2009
Covering:
Aoki J et al., Circulation 2009 Feb 10; 119:687
Cook S and Windecker S., Circulation 2009 Feb 10; 119:657
Incretin Mimetic Outperforms Sulfonylurea in Early Type 2 Diabetes
General Medicine
Summary and Comment
Liraglutide led to better glucose control and more weight loss at 1 year than did glimepiride.
By Bruce Soloway, MD
February 24, 2009
Covering:
Garber A et al., Lancet 2009 Feb 7; 373:473
Metabolic Monitoring: Who Gets It?
Psychiatry
Summary and Comment
Despite clear guidelines, clinicians rarely monitor glucose or lipids in patients receiving second-generation antipsychotics.
By Joel Yager, MD
February 23, 2009
Covering:
Haupt DW et al., Am J Psychiatry 2009 Jan 15
Metabolic Syndrome and Depression
Psychiatry
Summary and Comment
In women only, depressive symptoms predicted onset of metabolic syndrome.
By Joel Yager, MD
February 23, 2009
Covering:
Vanhala M et al., Acta Psychiatr Scand 2009 Feb; 119:137
Which Revascularization Strategy Is Best for Severe Coronary Artery Lesions?
Cardiology
Summary and Comment
Free
Results of the SYNTAX trial failed to show that PCI is noninferior to CABG in patients with 3-vessel or left main disease.
By Howard C. Herrmann, MD
February 18, 2009
Covering:
Serruys PW et al for the SYNTAX Investigators., N Engl J Med 2009 Feb 18
Lange RA and Hillis LD., N Engl J Med 2009 Feb 18
New Position Papers on Type 2 Diabetes Management
General Medicine
Summary and Comment
Free
One document offers a sensible treatment algorithm; the other offers perspective on the relation between glycemic control and macrovascular complications.
By Allan S. Brett, MD
February 3, 2009
Covering:
Skyler JS et al., Diabetes Care 2009 Jan; 32:187
Nathan DM et al., Diabetes Care 2009 Jan; 32:193
Rosiglitazone, Pioglitazone, and Fractures: A Meta-Analysis
General Medicine
Summary and Comment
Combined data from 10 trials show that rosiglitazone and pioglitazone confer significant risk for fractures.
Low-Glycemic-Index Diet and Diabetes
General Medicine
Summary and Comment
Oatmeal was better than brown rice in lowering HbA1c .
Rosiglitazone vs. Pioglitazone: A Comparison of Cardiovascular Outcomes
Cardiology
Summary and Comment
Results of a large observational study provide more evidence that rosiglitazone increases cardiovascular risk.
By Harlan M. Krumholz, MD, SM
January 7, 2009
Covering:
Winkelmayer WC et al., Arch Intern Med 2008 Nov 24; 168:2368
Nathan DM et al., Diabetes Care 2009 Jan; 32:193