Insulin vs. Oral Therapy for Newly Diagnosed Type 2 Diabetes
General Medicine Summary and Comment
Fears of adverse effects from early insulin treatment are not necessarily warranted.
By Allan S. Brett, MD
November 24, 2009
Covering:
Lingvay I et al., Diabetes Care 2009 Oct; 32:1789
Diabetes Control Among Urban Black Americans
General Medicine Summary and Comment
An intensive support program provided little benefit.
More on Adverse Effects of Antipsychotics on Children
Psychiatry Summary and Comment
An observational study details metabolic changes after 12 weeks of treatment with atypical antipsychotics.
By Barbara Geller, MD
November 9, 2009
Covering:
Correll CU et al., JAMA 2009 Oct 28; 302:1765
Varley CK and McClellan J., JAMA 2009 Oct 28; 302:1811
Comparison of Three Insulin Regimens
General Medicine Summary and Comment
Free
Adding once-daily basal insulin to oral therapy conferred some advantages over alternate regimens.
By Allan S. Brett, MD
November 5, 2009
Covering:
Holman RR et al., N Engl J Med 2009 Oct 29; 361:1736
Roden M., N Engl J Med 2009 Oct 29; 361:1801
Glucose Control in Type 2 Diabetes: Review of Cardiovascular Outcomes
General Medicine Summary and Comment
Intensive control led to fewer nonfatal MIs but no change in 5-year all-cause mortality.
We Need to Put Vitamin D Back in Children and Adolescents
Many U.S. children and adolescents have low vitamin D levels, and such levels are associated with adverse physiologic processes.
By Alain Joffe, MD, MPH, FAAP
November 4, 2009
Covering:
Kumar J et al., Pediatrics 2009 Sep; 124:e362
Reis JP et al., Pediatrics 2009 Sep; 124:e371
Ashraf A et al., J Clin Endocrinol Metab 2009 Sep; 94:3200
General Medicine Summary and Comment
Free
The drug provides little benefit and might cause harm.
Gabapentin–Nortriptyline Combination Therapy for Neuropathic Pain
General Medicine Summary and Comment
Pain intensity was lower with combination therapy than with either monotherapy.
By Bruce Soloway, MD
October 27, 2009
Covering:
Gilron I et al., Lancet 2009 Oct 10; 374:1252
Effect of Weight Loss on Obstructive Sleep Apnea in People with Type 2 Diabetes
General Medicine Summary and Comment
Losing 25 lbs resulted in significantly fewer OSA events in obese patients.
Resistant Hypertension: Is There a Role for a New Drug?
Cardiology Summary and Comment
An endothelin antagonist performed well in a randomized trial, but much research remains to be done.
By Joel M. Gore, MD
October 7, 2009
Covering:
Weber MA et al., Lancet 2009 Sep 14
Williams B., Lancet 2009 Sep 14
Walking Program for Patients with Impaired Glucose Tolerance
General Medicine Summary and Comment
Pedometer use resulted in more walking and lower glucose levels.
Does Treatment for Mild Gestational Diabetes Improve Pregnancy Outcomes?
Women's Health Summary and Comment
Free
Treatment lowered risk for maternal hypertensive disorders and complications related to excessive fetal growth, but not for perinatal mortality and severe neonatal complications.
By Ann J. Davis, MD
September 30, 2009
Covering:
Landon MB et al., N Engl J Med 2009 Oct 1; 361:1339
Sacks DA., N Engl J Med 2009 Oct 1; 361:1396
Angiotensin-Receptor Blockers for Microalbuminuria
General Medicine Summary and Comment
Free
ARBs didn't prevent adverse renal outcomes in patients with cardiovascular disease or diabetes.
By Richard Saitz, MD, MPH, FACP, FASAM
September 24, 2009
Covering:
Mann JFE et al., Ann Intern Med 2009 Jul 7; 151:1
Bilous R et al., Ann Intern Med 2009 Jul 7; 151:11
Parfrey PS., Ann Intern Med 2009 Jul 7; 151:63
Sex Hormone–Binding Globulin Is Linked to Type 2 Diabetes Risk
General Medicine Summary and Comment
Circulating SHBG levels predicted risk beyond that associated with traditional factors.
By Robert W. Rebar, MD
September 22, 2009
Covering:
Ding EL et al., N Engl J Med 2009 Sep 17; 361:1152
Diabetes Care in HIV-Infected Patients
HIV/AIDS Clinical Care Summary and Comment
Free
In a single-center, cross-sectional study, more than half of the HIV-infected patients with diabetes met the 2008 ADA goals for hemoglobin A1c levels, blood pressure, and lipid levels.
By Nancy Kim, MD, PhD, and Amy C. Justice, MD, PhD
September 21, 2009
Covering:
Adeyemi O et al., Clin Infect Dis 2009 Sep 1; 49:799
Mediterranean Diet Can Lower Need for Antihyperglycemic Medication in Type 2 Diabetes
General Medicine Summary and Comment
Four years after diabetes diagnosis, only 44% of patients on that diet required medication to reduce HbA1c levels.
Pioglitazone vs. Rosiglitazone in Older Patients with Type 2 Diabetes
General Medicine Summary and Comment
Pioglitazone was associated with lower risk for death and heart failure.
Albumin Excretion and Heart Failure
Cardiology Summary and Comment
A newly identified independent risk factor warrants further study.
Thiazolidinediones in Clinical Practice
Cardiology Summary and Comment
In a population-based cohort, pioglitazone demonstrated a better cardiovascular safety profile than rosiglitazone.
Botulinum Toxin for Diabetic Neuropathic Pain
Neurology Summary and Comment
Promising results from a small study
By Daniel D. Truong, MD
August 18, 2009
Covering:
Yuan R-Y et al., Neurology 2009 Apr 28; 72:1473
Skin Surgery in Patients with Diabetes
Dermatology Summary and Comment
Free
In patients undergoing skin surgery, diabetes was associated with increased risk for wound infections.
By George J. Hruza, MD
August 14, 2009
Covering:
Dixon AJ et al., Dermatol Surg 2009 Jul; 35:1035
Active Commuting and Cardiovascular Risk
Cardiology Summary and Comment
Walking or biking to work is associated with some favorable risk markers, but whether these practices confer a benefit is unclear.
How Much Evidence Do We Need to Change Practices in Which We Firmly Believe?
Enough already! Randomized trials show that tight glucose control in patients with long-standing type 2 diabetes isn't beneficial.
Reduced Innervation of Sweat Glands in Diabetic Neuropathy
Neurology Summary and Comment
A novel technique to quantify nerves around sweat glands allows identification of reduced innervation in diabetic neuropathy that correlates with neuropathy severity.
By Claudia Sommer, MD
July 21, 2009
Covering:
Gibbons CH et al., Neurology 2009 Apr 28; 72:1479
Investigational Once-Daily Incretin Mimetic Outperforms Twice-Daily Exenatide
General Medicine Summary and Comment
In this study, liraglutide had clinical advantages and was more convenient to use.
By Bruce Soloway, MD
July 16, 2009
Covering:
Buse JB et al., Lancet 2009 Jul 4; 374:39
