Metformin vs. Glipizide for Patients with Diabetes and Coronary Disease
General Medicine
Summary and Comment
Metformin was associated with better cardiovascular outcomes.
By Allan S. Brett, MD
June 18, 2013
Covering:
Hong J et al., Diabetes Care 2013 May; 36:1304
Capnography Useful in Identifying Patients with Diabetic Ketoacidosis
Emergency Medicine
Summary and Comment
In this study, end tidal CO2 values >24.5 mm Hg excluded DKA in most hyperglycemic patients.
Atorvastatin, Rosuvastatin, and Simvastatin Are Associated with Excess Risk for Diabetes
General Medicine
Summary and Comment
Free
Using low doses of these drugs might mitigate the risk.
By Paul S. Mueller, MD, MPH, FACP
June 11, 2013
Covering:
Carter AA et al., BMJ 2013 May 23; 346:f2610
Huupponen R and Viikari J., BMJ 2013 May 23; 346:f3156
Safety of Sitagliptin: An Observational Study
General Medicine
Summary and Comment
Sitagliptin wasn't associated with excess risk for hospitalization or death.
CAC Scores Improve Prediction of CV-Related Mortality in Diabetics
General Medicine
Summary and Comment
Free
Assessing coronary artery calcium was better than relying on traditional risk factors alone for determining cardiovascular risk.
Coronary Artery Bypass Grafting vs. Percutaneous Coronary Intervention for Multivessel Disease in the Community
Cardiology
Summary and Comment
In an observational study in Medicare patients, a long-term survival advantage of CABG was evident for patients with particular clinical characteristics.
By Joel M. Gore, MD
May 15, 2013
Covering:
Hlatky MA et al., Ann Intern Med 2013 Apr 23
Salutary Effects of Lower Energy Intake, Higher Physical Activity, and Weight Loss in Cuba
General Medicine
Summary and Comment
Weight changes related to economic hardship and recovery were associated with changes in diabetes incidence and cardiovascular-related mortality.
Sweetening the Brain: Higher Fasting Glucose Levels and Alzheimer-Like Abnormalities
Psychiatry
Summary and Comment
A study in cognitively healthy, nondiabetic individuals with family histories of dementia
Measuring Coronary Artery Calcium in People with Type 2 Diabetes Identifies a Low-Risk Subset
General Medicine
Summary and Comment
Coronary calcium scores might help stratify risk for adverse cardiovascular events.
Group Counseling for Children with Chronic Illness Is Effective
. . . and the benefits are enhanced when parents participate.
By Martin T. Stein, MD
April 3, 2013
Covering:
Scholten L et al., Pediatrics 2013 Apr; 131:e1196
Is Preoperative Diabetes Control Associated with Postoperative Complications?
General Medicine
Summary and Comment
In knee-replacement patients, the answer was largely "no."
By Allan S. Brett, MD
March 28, 2013
Covering:
Adams AL et al., J Bone Joint Surg Am 2013 Mar 20; 95:481
Intensive Glycemic Control and End-Stage Renal Disease in Type 2 Diabetes
General Medicine
Summary and Comment
Free
One case of ESRD was prevented for every 430 intensively treated patients.
By Allan S. Brett, MD
March 26, 2013
Covering:
Perkovic V et al., Kidney Int 2013 Mar; 83:517
Shurraw S and Tonelli M., Kidney Int 2013 Mar; 83:346
Correcting Low Vitamin D Levels in Obese Adolescents Improves Insulin Sensitivity
Adolescents who took 4000 IU of vitamin D3 daily had lower fasting insulin levels and insulin resistance than controls.
Is Sugar Intake Specifically Driving the Diabetes Epidemic?
General Medicine
Summary and Comment
In a country-by-country analysis, sugar availability is related to prevalence of diabetes.
ACE Inhibitor, ARB, or Both in Diabetic Renal Disease?
General Medicine
Summary and Comment
Dual therapy with angiotensin-converting–enzyme inhibitors plus angiotensin-receptor blockers was no better than monotherapy.
By Allan S. Brett, MD
March 5, 2013
Covering:
Fernandez Juarez G et al., Am J Kidney Dis 2013 Feb; 61:211
Pediatric DKA: Too Often a First-Time Diagnosis for Type 1 Diabetes
Emergency Medicine
Summary and Comment
One third of children in this multicenter study presented with DKA at the time of their initial diabetes diagnosis.
By Katherine Bakes, MD
March 1, 2013
Covering:
Klingensmith GJ et al., J Pediatr 2013 Feb; 162:330
Management Guidelines for Childhood Type 2 Diabetes Mellitus
Pediatrics and Adolescent Medicine
Clinical Practice Guideline Watch
Free
Guidelines for primary care management, including use of insulin, metformin, finger-stick blood glucose and HbA1c monitoring, and lifestyle modification
Branch Retinal Vein Occlusion Is Associated with Prior Hypertension and Diabetes
General Medicine
Summary and Comment
Subsequent comorbidities include hypertension, diabetes, and heart failure.
Pediatric Diabetic Ketoacidosis: Is Fluid Replacement Rate Associated with Cerebral Edema?
Emergency Medicine
Summary and Comment
Development of subclinical cerebral edema did not differ between children who received slower versus more rapid fluid replacement.
By Katherine Bakes, MD
January 11, 2013
Covering:
Glaser NS et al., Pediatrics 2013 Jan; 131:e73
Evolving Consensus on Managing Patients with Type 2 Diabetes
Aim for a reasonable and tailored program.
Painful Diabetic Neuropathy: A Three-Drug Comparison
General Medicine
Summary and Comment
Free
Amitriptyline, duloxetine, and pregabalin reduced pain to a similar extent.
By Allan S. Brett, MD
December 20, 2012
Covering:
Boyle J et al., Diabetes Care 2012 Dec; 35:2451
Guidelines for the Management of Stable Ischemic Heart Disease
Cardiology
Clinical Practice Guideline Watch
Free
New recommendations inform treatment strategies that balance life-saving interventions with symptom relief.
By Joel M. Gore, MD
December 19, 2012
Covering:
Fihn SD et al., Circulation 2012 Dec 18; 60:e44
Adverse CV Events with Metformin vs. Sulfonylureas
General Medicine
Summary and Comment
Free
In an observational study, cardiovascular risk was significantly lower among patients taking metformin.
Does Aliskiren Have a Role in Treating Patients with Diabetes?
General Medicine
Summary and Comment
In combination with an angiotensin-receptor blocker or angiotensin-converting–enzyme inhibitor, the drug was ineffective.
By Allan S. Brett, MD
November 29, 2012
Covering:
Parving H-H et al., N Engl J Med 2012 Dec 6; 367:2204
Direct Comparison of Long-Acting Exenatide vs. Liraglutide
General Medicine
Summary and Comment
At 6 months, type 2 diabetic patients who received liraglutide attained slightly lower glycosylated hemoglobin levels.