Pill Color Changes Are Associated with Nonadherence to Antiepileptic Medications
General Medicine
Summary and Comment
Especially in patients with seizure disorder, drug colors matter.
Maternal Antidepressant Use and Perinatal Mortality
Women's Health
Summary and Comment
Free
Use of selective serotonin reuptake inhibitors does not seem to raise risk for stillbirth or infant death.
Cognitive-Behavioral Therapy for Patients with Treatment-Resistant Depression
General Medicine
Summary and Comment
CBT added to antidepressant drugs was beneficial in primary care practices.
Early Cognitive Remediation in Major Depression and Psychosis
Psychiatry
Summary and Comment
Free
After the first episode of illness, a remediation program improved learning, memory, and psychosocial function.
Adding Moderate-Dose Lithium to Other Bipolar Treatments: Is There a Benefit?
Psychiatry
Summary and Comment
Symptomatic patients receiving lithium added to optimized personal treatment did no better than patients not taking lithium but had less antipsychotic exposure.
By Joel Yager, MD
January 14, 2013
Covering:
Nierenberg AA et al., Am J Psychiatry 2013 Jan; 170:102
Psychotropics Are Not Overused by Mainstream Adolescents
Psychiatry
Summary and Comment
A stark contrast between findings of low medication use in conventional settings versus reported high use in specialized facilities
By Barbara Geller, MD
January 14, 2013
Covering:
Merikangas KR et al., Arch Pediatr Adolesc Med 2012 Dec 3
Psychotherapy to Prevent PTSD
Psychiatry
Summary and Comment
Free
A targeted behavioral approach helps individuals soon after they experience trauma.
By Steven Dubovsky, MD
January 7, 2013
Covering:
Rothbaum BO et al., Biol Psychiatry 2012 Dec 1; 72:957
Folate for Treatment-Resistant Depression
Psychiatry
Summary and Comment
Supplementing SSRIs with the biologically available form of folate increases response but not remission rates.
By Joel Yager, MD
January 7, 2013
Covering:
Papakostas GI et al., Am J Psychiatry 2012 Dec 1; 169:1267
Nelson JC., Am J Psychiatry 2012 Dec 1; 169:1223
Mental Health Alert: Bullies in the Workplace!
Psychiatry
Summary and Comment
This prospective cohort study shows that workers reporting bullying at work are more likely to receive subsequent treatment with psychotropic medication.
By Peter Roy-Byrne, MD
January 7, 2013
Covering:
Lallukka T et al., BMJ Open 2012 Dec 12; 2:e001660
Adjunctive Mifepristone for Cognitive Dysfunction in Bipolar Depression
Psychiatry
Summary and Comment
In women, a long-term effect on working memory from short-term mifepristone use
By Steven Dubovsky, MD
January 7, 2013
Covering:
Watson S et al., Biol Psychiatry 2012 Dec 1; 72:943
Firing of Dopamine Neurons Regulates Depression
Psychiatry
Summary and Comment
Experiments on mesolimbic dopamine neurons in rodents suggest a basis for deep brain stimulation of the nucleus accumbens in treatment-resistant depression.
The Risk for Melanoma in Large, Congenital Melanocytic Nevi
Dermatology
Summary and Comment
Free
After LCMN surgery, the risk for malignant transformation is reduced but not negligible, and scarring may affect cosmetic improvement.
By Mary Wu Chang, MD
January 4, 2013
Covering:
Vourc'h-Jourdain M et al., J Am Acad Dermatol 2012 Nov 19
A Polymorphism That May Predict Antidepressant Dosing
Psychiatry
Summary and Comment
Free
Depressed patients carrying a single nucleotide polymorphism on a gene that influences the blood–brain barrier required half the escitalopram dose to achieve remission.
By Joel Yager, MD
December 21, 2012
Covering:
Singh AB et al., Transl Psychiatry 2012 Nov 27; 2:e198
Prolonged Stress Causes Cell Death in Midbrain Gray Matter
Psychiatry
Summary and Comment
In a rat model of PTSD, immobilization and forced swimming induce apoptosis in the dorsal raphe nucleus.
By Joel Yager, MD
December 21, 2012
Covering:
Liu D et al., BMC Psychiatry 2012 Nov 27; 12:211
Omega-3 Fatty Acids for Depression, Revisited: The Jury Is Coming Back In
Psychiatry
Summary and Comment
The amount of eicosapentaenoic acid is critical to efficacy, and the supplement is less likely to work for mild depression.
By Peter Roy-Byrne, MD
December 10, 2012
Covering:
Bloch MH and Hannestad J., Mol Psychiatry 2012 Dec; 17:1272
Martins JG et al., Mol Psychiatry 2012 Dec; 17:1144
Lin P-Y et al., Mol Psychiatry 2012 Dec; 17:1161
Bloch MH and Hannestad J., Mol Psychiatry 2012 Dec; 17:1163
Add-On Memantine for Obsessive-Compulsive Disorder
Psychiatry
Summary and Comment
Adding memantine to a selective serotonin reuptake inhibitor improved outcomes in patients with moderate-to-severe OCD.
By Deborah Cowley, MD
December 10, 2012
Covering:
Ghaleiha A et al., J Psychiatr Res 2012 Oct 9
A Predictor of PTSD?
Psychiatry
Summary and Comment
In deployed soldiers, high predeployment CO2 reactivity was associated with risk for developing PTSD.
By Steven Dubovsky, MD
December 10, 2012
Covering:
Telch MJ et al., Arch Gen Psychiatry 2012 Nov 1; 69:1161
Pediatric Psoriasis Is Associated with Higher Risk for Psychiatric Disorders
Dermatology
Summary and Comment
Free
Elevated risks were especially significant for depression and anxiety.
By Mary Wu Chang, MD
December 7, 2012
Covering:
Kimball AB et al., J Am Acad Dermatol 2012 Oct; 67:651
N -Acetylcysteine for Refractory OCD
Psychiatry
Summary and Comment
Free
This derivative of cysteine, with glutamate-modulating properties, provides modest benefits to patients who are symptomatic after an initial antidepressant trial.
By Peter Roy-Byrne, MD
December 3, 2012
Covering:
Afshar H et al., J Clin Psychopharmacol 2012 Dec; 32:797
Clean Urines Win the Prize in Patients with Dual Diagnosis
Psychiatry
Summary and Comment
Contingency rewards can reduce co-occurring stimulant use in the seriously mentally ill.
By Joel Yager, MD
December 3, 2012
Covering:
McDonell MG et al., Am J Psychiatry 2012 Nov 9
Pathway for Light Effects on Mood and Cognition
Psychiatry
Summary and Comment
In an animal study, change in light exposure increases corticosterone, depresses mood, and impairs learning via intrinsically photosensitive retinal ganglion cells.
By Barbara Geller, MD
December 3, 2012
Covering:
LeGates TA et al., Nature 2012 Nov 22; 491:594
A Violent Itch
Dermatology
Summary and Comment
Free
Sensitivity to itch and pain was intensified by induction of negative emotions.
By Mark V. Dahl, MD
November 30, 2012
Covering:
van Laarhoven AIM et al., Br J Dermatol 2012 Aug; 167:262
Adverse Pregnancy Outcomes and Bipolar Disorder
Psychiatry
Summary and Comment
Free
The increased risks are independent of treatment for the disorder.
By Deborah Cowley, MD
November 19, 2012
Covering:
Boden R et al., BMJ 2012 Nov 8; 345:e7085
Treatment Choices for Resistant Bipolar Disorder
Psychiatry
Summary and Comment
Several options exist, including clozapine.
By Jonathan Silver, MD
November 19, 2012
Covering:
Kemp DE et al., Bipolar Disord 2012 Nov; 14:780
Nielsen J et al., Bipolar Disord 2012 Oct 26
Poon SH et al., Bipolar Disord 2012 Sep; 14:573
Not Sleeping Costs Money
Psychiatry
Summary and Comment
Insomnia, independent of chronic conditions, is associated with workplace accidents and/or errors in an epidemiologically based study.
By Steven Dubovsky, MD
November 19, 2012
Covering:
Shahly V et al., Arch Gen Psychiatry 2012 Oct 1; 69:1054