Specific MicroRNAs That Suppress Breast Cancer Metastasis
General Medicine Summary and Comment
Restoring levels of certain miRNAs suppressed metastases in mice.
Variation in Breast Cancer Risk Among BRCA1 or 2 Carriers
Although women in carrier families are at higher risk for breast cancer than are those in noncarrier families, other variables play into the penetrance of <$EMPH_O>BRCA<$EMPH_C>-associated disease.
By Virginia Kaklamani, MD, DSc
January 29, 2008
Covering:
Begg CB et al., JAMA 2008 Jan 9/16; 299:194
Anastrozole vs. Tamoxifen in Early Breast Cancer: A Long-Term Update
General Medicine Summary and Comment
After 5 years of therapy and 3 years of follow-up, disease recurrence was diminished by anastrozole, but overall mortality was the same in the two groups.
By Allan S. Brett, MD
January 24, 2008
Covering:
The Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists’ Group., Lancet Oncol 2008 Jan; 9:45
To Avert Tamoxifen-Associated Endometrial Polyps, LNG-IUS Could Be the Answer
Women's Health Summary and Comment
Free
The levonorgestrel intrauterine system prevented the occurrence of endometrial polyps in women taking tamoxifen.
Cost Sharing’s Effect on Screening Mammography
Women's Health Summary and Comment
Requiring co-pays reduced utilization of screening mammography.
By Andrew M. Kaunitz, MD
January 24, 2008
Covering:
Trivedi AN et al., N Engl J Med 2008 Jan 24; 358:375
Bach PB., N Engl J Med 2008 Jan 24; 358:411
ATAC at 100! (Months)
Anastrozole benefited women with early breast cancer for at least 3.5 years after treatment ended.
By William J. Gradishar, MD
January 22, 2008
Covering:
The Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists’ Group., Lancet Oncol 2008 Jan; 9:45
Antiangiogenic Therapy for Breast Cancer: One Step Forward, Two Steps Back?
Bevacizumab has not been approved yet for treatment of patients with metastatic breast cancer, despite evidence of benefit.
By William J. Gradishar, MD
January 15, 2008
Covering:
Miller K et al., N Engl J Med 2007 Dec 27; 357:2666
Miller R., Wall Street Journal 2007 Dec 28
Diagnostic Mammograms: Interpretation Is in the Eye of the Beholder
Women's Health Summary and Comment
Free
Sensitivity and false-positive rates varied among radiologists’ interpretations of diagnostic mammograms.
By Andrew M. Kaunitz, MD
January 10, 2008
Covering:
Miglioretti DL et al., J Natl Cancer Inst 2007 Dec 19; 99:1854
Obesity and Cancer in Women
Cardiology Summary and Comment
New evidence from the Million Women Study finds increased risk for six cancers not previously associated with high BMI.
By Beat J. Meyer, MD
January 9, 2008
Covering:
Reeves GK et al., BMJ 2007 Dec 1; 335:1134
Mechanism of ER-Negative Breast Cancer in BRCA1 -Mutation Carriers
Oncology and Hematology Summary and Comment
Free
BRCA1 protein directly regulates the estrogen-receptor
By William J. Gradishar, MD
December 11, 2007
Covering:
Hosey AM et al., J Natl Cancer Inst 2007 Nov 13
Jordan VC., J Natl Cancer Inst 2007 Nov 13
Increasing BMI Is Associated with Increased Cancer Risk and Mortality in Women
General Medicine Summary and Comment
Obese women had increased risk for all cancers and 10 of 17 types of cancers.
By Paul S. Mueller, MD, MPH, FACP
December 6, 2007
Covering:
Reeves GK et al., BMJ 2007 Dec 1; 335:1134
More Breast Cancer Patients Choosing Contralateral Prophylactic Mastectomy
Women's Health Summary and Comment
In recent years, rates of CPM among U.S. breast cancer patients have more than doubled.
Gene Signatures Predict Response to Cancer Therapy
Identifying patients who will not respond to standard chemotherapy would permit direct entry into investigational regimens.
Do Oral Contraceptives Affect Risk for Death from Breast Cancer?
Women's Health Summary and Comment
OC use had neither a beneficial nor a harmful effect on breast cancer mortality.
Do HT Use and Hormone-Receptor Status Affect Recurrence After Treatment for Early-Stage Breast Cancer?
Hormone-receptor–positive tumor status resulted in lower risk for recurrence among women who have used HT.
Cardiovascular Effects of Therapies for Early Breast Cancer
General Medicine Summary and Comment
Multiple factors associated with therapy may combine to heighten cardiovascular risks.
Surgeons’ Volume Status Doesn’t Affect Cancer-Related Mortality in Older Women with Early-Stage Breast Cancer
Overall mortality, but not cancer-related mortality, was higher among women whose surgeons performed five or fewer procedures annually.
Putting Breast Self-Examination in Its Place
Women's Health Practice Watch
Healthcare providers should stop insisting that monthly BSE be performed in a specified manner.
By Wendy S. Biggs, MD
November 1, 2007
Covering:
Canadian Cancer Society.,
American Cancer Society.,
CHF in Older Women After Adjuvant Anthracycline-Based Chemotherapy for Breast Cancer
Oncology and Hematology Summary and Comment
Free
Adjuvant therapy that includes anthracyclines raises risk for adverse cardiac events.
Possible Way to Inhibit Human Breast Cancer Metastasis
General Medicine Summary and Comment
Preventing CCL5 from linking with its receptor on cancer cells greatly reduces their metastatic potential.
Aromatase-Inhibitor–Induced Joint Complaints: An Underappreciated Problem?
Joint complaints are common among women who receive AIs.
Who Needs a Taxane? Tailoring Breast Cancer Therapy
Oncology and Hematology Summary and Comment
Free
Women with HER2-positive tumors benefited from paclitaxel therapy, regardless of the ER status of the tumors.
By William J. Gradishar, MD
October 10, 2007
Covering:
Hayes DF et al., N Engl J Med 2007 Oct 11; 357:1496
Moore A., N Engl J Med 2007 Oct 11; 357:1547
Mammography Reduces Breast Cancer Mortality: More Evidence
Women's Health Summary and Comment
A new U.S. study found that mammography screening saves lives, particularly in women 50 and older.
By Andrew M. Kaunitz, MD
October 4, 2007
Covering:
Norman SA et al., Cancer Causes Control 2007 Nov; 18:909
MRI to Diagnose Pure DCIS?
About half of biopsy-proven high-grade DCIS that was visualized with MRI was mammographically occult.
Joint Symptoms in Women Taking Aromatase Inhibitors for Breast Cancer
General Medicine Summary and Comment
Patients who received aromatase inhibitors commonly reported joint symptoms.
By Allan S. Brett, MD
September 27, 2007
Covering:
Crew KD et al., J Clin Oncol 2007 Sep 1; 25:3877
