Tolerance of Baked Milk Predicts Transient Cow's Milk Allergy
Adding baked milk products to the diet hastens development of tolerance to uncooked milk.
By David J. Amrol, MD
June 22, 2011
Covering:
Kim JS et al., J Allergy Clin Immunol 2011 May 23
Demographics of Chronic Actinic Dermatitis Have Changed
Dermatology Summary and Comment
The conventional wisdom that this photosensitivity occurs almost entirely in older, dark-skinned men no longer holds true.
Do Drug-Induced and Non–Drug-Induced Subacute Cutaneous Lupus Erythematosus Differ?
Dermatology Summary and Comment
The authors of a case report conclude that distinctive cutaneous features differentiate the two, but Dr. Callen disagrees.
Lung Function After Tiotropium in Patients with Severe Asthma
General Medicine Summary and Comment
As an add-on therapy, tiotropium improved lung function at 8 weeks.
By David J. Amrol, MD
June 14, 2011
Covering:
Kerstjens HAM et al., J Allergy Clin Immunol 2011 May 31
Omalizumab for Inadequately Controlled Severe Asthma
General Medicine Summary and Comment
As add-on treatment, it prevented some exacerbations in patients with severe allergic asthma.
By Jamaluddin Moloo, MD, MPH , and David J. Amrol, MD
June 7, 2011
Covering:
Hanania NA et al., Ann Intern Med 2011 May 3; 154:573
On the Horizon: Test to Predict Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Dermatology Summary and Comment
A rapid immunochromatographic test for serum granulysin shows promise in a small study.
Cutaneous Lesions of Azathioprine Hypersensitivity Syndrome
Dermatology Summary and Comment
These authors suggest that most cutaneous manifestations of azathioprine hypersensitivity represent neutrophilic dermatoses, but do they?
Immunoglobulin Therapy for Solar Urticaria
Dermatology Summary and Comment
Intravenous immunoglobulin therapy can help when options are limited, but adverse effects are a concern.
Greater Role for Leukotriene-Receptor Antagonists in Asthma?
General Medicine Summary and Comment
In real-world practices, these drugs compared favorably with guideline-recommended first-line agents.
By David J. Amrol, MD
May 10, 2011
Covering:
Price D et al., N Engl J Med 2011 May 5; 364:1695
Dahlén S-E et al., N Engl J Med 2011 May 5; 364:1769
Off-Label Use of Azathioprine in Dermatology
Dermatology Summary and Comment
A systematic review points to the need for long-term registries to ensure evidence-based healthcare decision making in dermatology.
Oxymetazoline Boosts Intranasal Steroids' Effects Without Rebound Congestion
General Medicine Summary and Comment
Good news for patients with severe nighttime nasal congestion
By David J. Amrol, MD
April 28, 2011
Covering:
Baroody FM et al., J Allergy Clin Immunol 2011 Apr; 127:927
Oral Food Challenges Distinguish Food Sensitization from Allergy
Most children on elimination diets based on immunoassay results have negative oral food challenge tests.
By Howard Bauchner, MD
April 27, 2011
Covering:
Fleischer DM et al., J Pediatr 2011 Apr; 158:578.e1
Night Sweats Associated with Other Sleep Disturbances in Children
Night sweats were significantly associated with eye diseases, atopic dermatitis, respiratory disorders, hyperactivity, anxiety, and other sleep-related symptoms.
HLA Screening Could Reduce the Risk for Toxic Epidermal Necrolysis and Other Rashes
Dermatology Summary and Comment
Free
HLA-B*1502 screening may totally prevent carbamazepine-induced SJS-TEN in Chinese and South Asian populations; HLA-A*3101 screening may dramatically reduce SJS-TEN and other rash syndromes in patients with European or Japanese ancestry.
By Neil H. Shear, MD, FRCPC
April 8, 2011
Covering:
Chen P et al for the Taiwan SJS Consortium., N Engl J Med 2011 Mar 24; 364:1126
McCormack M et al., N Engl J Med 2011 Mar 24; 364:1134
Ozeki T et al., Hum Mol Genet 2011 Mar 1; 20:1034
Don't Just Eat Dirt, Breathe Dirt!
Dermatology Summary and Comment
Free
Colonization with a variety of microbes from early childhood appears to be important for balanced immunologic development,
By Mary Wu Chang, MD
April 1, 2011
Covering:
Ege MJ et al., N Engl J Med 2011 Feb 24; 364:701
Gern JE., N Engl J Med 2011 Feb 24; 364:769
Are Swimming Pools Safe for Children with Asthma?
In this prospective birth cohort study, swimming did not increase risk for asthma or atopy.
By David J. Amrol, MD
March 23, 2011
Covering:
Font-Ribera L et al., Am J Respir Crit Care Med 2011 Mar 1; 183:582
Piacentini GL and Baraldi E., Am J Respir Crit Care Med 2011 Mar 1; 183:569
Bernard A et al., Am J Respir Crit Care Med 2011 Mar 1; 183:570
Tight Barriers
Dermatology Summary and Comment
Barrier defects in the tight junctions of the epidermis are significantly associated with atopic dermatitis.
By Mark V. Dahl, MD
March 18, 2011
Covering:
De Benedetto A et al., J Allergy Clin Immunol 2011 Mar; 127:773
Do Inhaled Steroids Raise Pneumonia Risk in Asthma Patients?
General Medicine Summary and Comment
An industry-sponsored meta-analysis says no.
By Allan S. Brett, MD
March 17, 2011
Covering:
O'Byrne PM et al., Am J Respir Crit Care Med 2011 Mar 1; 183:589
Anti-IgE Therapy for Allergic Asthma in Inner-City Children
Adding omalizumab to guideline-based therapy significantly reduced symptoms, exacerbations, and use of inhaled corticosteroids.
By David J. Amrol, MD
March 16, 2011
Covering:
Busse WW et al., N Engl J Med 2011 Mar 17; 364:1005
One More Reason Not to Smoke: Adult-Onset Atopic Dermatitis
Dermatology Summary and Comment
Smoking and exposure to environmental tobacco smoke increased the risk for AD in adulthood.
By Mary Wu Chang, MD
March 11, 2011
Covering:
Lee CH et al., Br J Dermatol 2010 Nov 4
Inhaled Steroids as Rescue Therapy in Mild Persistent Asthma?
General Medicine Summary and Comment
The authors argue that step-down to inhaled steroids for rescue only might be a better strategy than complete discontinuation of controller medications in children.
By Bruce Soloway, MD
March 8, 2011
Covering:
Martinez FD et al., Lancet 2011 Feb 19; 377:650
Atopic Dermatitis and Cataracts: A Cloudy Issue
Dermatology Summary and Comment
Long-term corticosteroid treatment, onset in infancy, and family history of AD increase risks for cataracts in children.
By Mary Wu Chang, MD
February 25, 2011
Covering:
Bair B et al., Arch Dermatol 2011 Jan 17
Skin Testing for β-Lactam Reactions
Most childhood rashes following β-lactam treatment are not allergic.
By David J. Amrol, MD
February 23, 2011
Covering:
Caubet JC et al., J Allergy Clin Immunol 2011 Jan; 127:218
DRESS — A New Association?
Dermatology Summary and Comment
Too much caffeine was the suspected culprit in this case report.
How Do Systemic Steroids Suppress Contact Allergies?
Dermatology Summary and Comment
Systemic steroids increase TGF-β, thereby inducing a chain of actions that eventually improve contact allergies.
By Craig A. Elmets, MD
February 11, 2011
Covering:
Stary G et al., J Immunol 2011 Jan 1; 186:103
