Comparison of Three Insulin Regimens
General Medicine Summary and Comment
Free
Adding once-daily basal insulin to oral therapy conferred some advantages over alternate regimens.
By Allan S. Brett, MD
November 5, 2009
Covering:
Holman RR et al., N Engl J Med 2009 Oct 29; 361:1736
Roden M., N Engl J Med 2009 Oct 29; 361:1801
Multifocal Glasses and Risk for Falling
General Medicine Summary and Comment
Ground-level obstacles can be precarious with these glasses.
By Allan S. Brett, MD
November 5, 2009
Covering:
Menant JC et al., J Am Geriatr Soc 2009 Oct; 57:1833
B-Type Natriuretic Peptide to Rule out Heart Failure: Different Cutoffs for Different Patients?
Cardiology Summary and Comment
Adjusting BNP thresholds for clinical covariates improved the test's ability to differentiate between cardiac and noncardiac causes of dyspnea.
By Joel M. Gore, MD
November 4, 2009
Covering:
Rogers RK et al., Am J Cardiol 2009 Sep 1; 104:689
Supplemental and Active Forms of Vitamin D Prevent Falls Among Elders
General Medicine Summary and Comment
Daily doses of vitamin D >700 IU were associated with significantly fewer falls.
Screening for Prostate and Breast Cancers
Have the benefits been overstated?
Fewer Falls with Vitamin D
Women's Health Summary and Comment
High-dose vitamin D lowered risk for falls in older individuals.
By Wendy S. Biggs, MD
October 29, 2009
Covering:
Bischoff-Ferrari HA et al., BMJ 2009 Oct 1; 339:b3692
Hormone Therapy Is Associated with Excess Lung Cancer Mortality in WHI Participants
General Medicine Summary and Comment
NSCLCs were more aggressive in hormone recipients.
By Bruce Soloway, MD
October 27, 2009
Covering:
Chlebowski RT et al., Lancet 2009 Oct 10; 374:1243
Midlife Overweight and Obesity Predict Lower Chance for Healthy Survival After Age 70
General Medicine Summary and Comment
For every unit of BMI >25 kg/m2 at midlife, odds for disease-free survival at age 70 decreased by 12%.
Trends in Hip Fracture Incidence and Mortality — 1986–2005
General Medicine Summary and Comment
Incidence peaked in 1995, and then declined; mortality was down overall.
Glucocorticoid Use Is Associated with Risk for Atrial Fibrillation
General Medicine Summary and Comment
A large case-control study suggests that glucocorticoid use is linked to AF.
Effect of Weight Loss on Obstructive Sleep Apnea in People with Type 2 Diabetes
General Medicine Summary and Comment
Losing 25 lbs resulted in significantly fewer OSA events in obese patients.
Aldosterone Antagonists and Heart Failure
Cardiology Summary and Comment
Potholes remain in the road toward adoption of evidence-based guideline recommendations.
Daunorubicin for Older Adults with Acute Myeloid Leukemia
High-dose daunorubicin improved complete response rates in patients aged 60 and older but did not improve survival overall.
By Michael E. Williams, MD
October 20, 2009
Covering:
Löwenberg B et al., N Engl J Med 2009 Sep 24; 361:1235
Dombret H and Gardin C., N Engl J Med 2009 Sep 24; 361:1301
Early Endoscopy for Older Patients with Bleeding Peptic Ulcers
Gastroenterology Summary and Comment
Compared with delayed endoscopies, early procedures were associated with shorter hospital stays and lower rates of surgery.
Treatment of Localized Prostate Cancer in the Era of PSA Screening
General Medicine Summary and Comment
Watchful waiting is appropriate in older men with localized cancers.
Clinical Course of Advanced Dementia
General Medicine Summary and Comment
Free
As we suspected: Advanced dementia is a terminal illness.
By Allan S. Brett, MD
October 14, 2009
Covering:
Mitchell SL et al., N Engl J Med 2009 Oct 15; 361:1529
Dialysis in Elders
General Medicine Summary and Comment
When dialysis is initiated in older patients, death or substantial functional decline often is noted at 1 year.
By Thomas L. Schwenk, MD
October 14, 2009
Covering:
Kurella Tamura M et al., N Engl J Med 2009 Oct 15; 361:1539
Arnold RM and Zeidel ML., N Engl J Med 2009 Oct 15; 361:1597
"Hospital at Home" for Elders with Acute Heart Failure
General Medicine Summary and Comment
Compared with hospitalization, home care was associated with similar mortality and lower costs.
By Jamaluddin Moloo, MD, MPH
October 13, 2009
Covering:
Tibaldi V et al., Arch Intern Med 2009 Sep 28; 169:1569
Kao H and Walter LC., Arch Intern Med 2009 Sep 28; 169:1576
Conservative Management of Localized Prostate Cancer
Disease surveillance might be appropriate in certain men.
Neuroimaging with Pittsburgh Compound B in Patients with Mild Cognitive Impairment
Neurology Summary and Comment
MCI patients with amyloid retention identified by PiB most likely have very early AD.
By Rawan Tarawneh, MD, and John C. Morris, MD
October 13, 2009
Covering:
Wolk DA et al., Ann Neurol 2009 May; 65:557
Dermatology Summary and Comment
Free
Insufficient tumor necrosis factor affected the ability of T lymphocytes to migrate to the skin.
By Craig A. Elmets, MD
October 9, 2009
Covering:
Agius E et al., J Exp Med 2009 Aug 31; 206:1929
Antibiotic Guideline Compliance and Outcomes for CAP
Emergency Medicine Summary and Comment
Two large studies support guideline-based care.
By J. Stephen Bohan, MD, MS, FACP, FACEP
October 9, 2009
Covering:
McCabe C et al., Arch Intern Med 2009 Sep 14; 169:1525
Arnold FW et al., Arch Intern Med 2009 Sep 14; 169:1515
Sharpe BA., Arch Intern Med 2009 Sep 14; 169:1462
Screening Test for Stroke-Related Dysphagia
General Medicine Summary and Comment
Most patients who had problems swallowing in the ED had dysphagia on formal evaluations by speech pathologists.
By Allan S. Brett, MD
October 8, 2009
Covering:
Turner-Lawrence DE et al., Ann Emerg Med 2009 Sep; 54:344
Surgery vs. Noninvasive Therapy for Carpal Tunnel Syndrome
General Medicine Summary and Comment
Surgery was more effective than other noninvasive therapies, but either treatment modality benefited patients.
By Bruce Soloway, MD
October 8, 2009
Covering:
Jarvik JG et al., Lancet 2009 Sep 26; 374:1074
Management of Chronic Pain
Comprehensive treatment for chronic pain must address both physical and psychological aspects.
By Lynn Rader, MD
October 8, 2009
