From the publishers of The New England Journal of Medicine

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STDs

The latest information on sexually transmitted diseases — summaries and comments on Chlamydia, gonorrhea, herpes, HIV, HPV, syphilis, and more — drawn from across our primary care and specialty care areas. Sign up now for monthly e-mail alerts on new content.

SUMMARY AND COMMENT

Cutaneous Non–AIDS-Defining Cancers in HIV-Infected Individuals

Such cancers are not associated with immune status or receipt of ART.

SUMMARY AND COMMENT

Clinical Effectiveness of HBV Vaccination in HIV-Positive Patients

In an observational cohort study that showed a high incidence of hepatitis B virus infection after HIV diagnosis, HBV vaccination was effective only in a subgroup with HBV surface antibody titers ≥10 IU/L.

SUMMARY AND COMMENT

Rifampin-Resistant TB During Boosted PI Therapy in HIV Patients

In New York City, three HIV patients with tuberculosis developed rifampin resistance after being switched to boosted PI therapy and alternate-day rifabutin.

SUMMARY AND COMMENT

PEPFAR in Sub-Saharan Africa: Effects on HIV-Related Outcomes

An analysis of PEPFAR’s effectiveness in 12 African countries reveals a significant decrease in the number of HIV-related deaths, but not in HIV prevalence.

SUMMARY AND COMMENT

Recycling Enfuvirtide: Possible Clinical Benefit

Salvage therapy that included enfuvirtide appeared to show a survival benefit in a small, uncontrolled, retrospective study of HIV-positive patients who had already experienced virologic failure on an enfuvirtide-containing regimen.

SUMMARY AND COMMENT

ART and Neurocognitive Function

HIV-infected patients with neurocognitive impairment can show progressive improvement in function for at least 48 weeks after starting ART.

SUMMARY AND COMMENT

HPV Vaccine for Women in Mid-Adulthood

Infection and disease were prevented in women between the ages of 24 and 45.

SUMMARY AND COMMENT

MRSA Colonization and Infection in HIV-Infected Patients

The increased rate of MRSA colonization in HIV-infected patients probably explains their elevated rate of MRSA skin and soft-tissue infections.

SUMMARY AND COMMENT

High Rate of New HIV Infection in Late Pregnancy

Among pregnant women in South Africa, repeat testing conducted between 36 and 40 weeks of gestation revealed new HIV infection in 3%.

SUMMARY AND COMMENT

CNS Penetration of ART and Cognitive Performance: An Unexpected Finding

Increased CNS penetration effectiveness of the ART regimen was associated with poorer neurocognitive outcomes, despite increased rates of CSF viral suppression.

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