From the publishers of The New England Journal of Medicine

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Skin Cancer

The latest information on basal cell carcinoma, chemotherapy, melanoma, squamous cell carcinoma, and more, drawn from across our primary care and specialty care areas. Sign up now for monthly e-mail alerts on new content.

SUMMARY AND COMMENT

PPAR for the Melanoma Course

Glitazones represent a new direction for developing molecularly targeted anticancer agents.

SUMMARY AND COMMENT

Cutaneous Non–AIDS-Defining Cancers in HIV-Infected Individuals

Such cancers are not associated with immune status or receipt of ART.

SUMMARY AND COMMENT

Ingenol Mebutate for Actinic KeratosesFree

A short course of this plant-based agent significantly improved AK clearance.

SUMMARY AND COMMENT

Melanocytes in Lymph Nodes: BRAF Is Not the Answer

Evidence of BRAF mutation in sentinel node tissue is insufficient to diagnose metastasis, as this mutation also appears in benign nodal nevi.

SUMMARY AND COMMENT

Mice Capades

Activating Braf mutation and silencing Pten in melanocytes provoked melanoma with metastasis in mice.

SUMMARY AND COMMENT

Heavy Metal in Melanoma

Mutations that restricted the production of a matrix metalloprotein diminished tumor suppression and fostered aggressive characteristics in cancer cells.

SUMMARY AND COMMENT

A Potential Overcall: Recurrent Melanocytic Nevi

These lesions resemble malignant melanomas with regression, but clinical characteristics can help to differentiate the two.

FEATURE

Briefly Noted

Counseling patients at risk for melanoma, factors associated with malignancy in dermatomyositis, guidelines for safe use of methotrexate for psoriasis, and a new TNF-{alpha} antibody, administered by subcutaneous injection

FEATURE

Vitamin D and HealthFree

Do we have enough? How do we get more? What systems are affected?

SUMMARY AND COMMENT

Oncogenic Lesions in LentiginesFree

Researchers establish a genetic link between keratoses and lentigines, but not all mutations lead to cancer.

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