Lipid Management
The latest information on HDL and LDL cholesterol, metabolic syndrome, statins, triglycerides, and more, drawn from across our primary care and specialty care areas. Sign up now for monthly e-mail alerts on new content.
SUMMARY AND COMMENT
Lipid-Lowering Therapy in HIV-Infected Patients
- November 18, 2009
- Rajesh T. Gandhi, MD
- Infectious Diseases
Gemfibrozil levels are reduced by lopinavir/ritonavir coadministration, which may explain the difficulty in lowering triglycerides in HIV-infected patients.
- Reviewing:
- Busse KH et al. J Acquir Immune Defic Syndr 2009 Oct 1; 52:235
SUMMARY AND COMMENT
Rosuvastatin Beats Pravastatin for PI-Associated Hyperlipidemia
- November 16, 2009
- Abigail Zuger, MD
- HIV/AIDS Clinical Care
However, the study was small, and patients were followed for only 45 days.
- Reviewing:
- Aslangul E et al. AIDS 2009 Oct 15
SUMMARY AND COMMENT
ARBITER 6-HALTS: A Surprise KnockoutFree
- November 15, 2009
- Harlan M. Krumholz, MD, SM
- Cardiology
Niacin's clear win over ezetimibe as an adjunct to statin therapy challenges assumptions about lipid management.
- Reviewing:
- Taylor AJ et al. N Engl J Med 2009 Nov 16:361
SUMMARY AND COMMENT
What Can the Antiphospholipid Syndrome Teach Us About HDL?
- November 10, 2009
- JoAnne M. Foody, MD
- Cardiology
Low paraoxonase activity in women with APS correlated with dysfunctional HDL and arterial abnormalities.
- Reviewing:
- Charakida M et al. JAMA 2009 Sep 16; 302:1210
SUMMARY AND COMMENT
More on Adverse Effects of Antipsychotics on Children
- November 9, 2009
- Barbara Geller, MD
- Psychiatry
An observational study details metabolic changes after 12 weeks of treatment with atypical antipsychotics.
- Reviewing:
- Correll CU et al. JAMA 2009 Oct 28; 302:1765
SUMMARY AND COMMENT
Effect of Statins on Responses to Interferon Beta-1a
- October 6, 2009
- Hillel Panitch, MD
- Neurology
A retrospective study suggests that statins do not interfere with the therapeutic effects of IFNβ-1a in multiple sclerosis, but methodologic problems render the issue unresolved.
- Reviewing:
- Rudick RA et al. Neurology 2009 Jun 9; 72:1989
SUMMARY AND COMMENT
Refining Antiplatelet Treatment in Patients with Acute Coronary Syndromes
- September 2, 2009
- Beat J. Meyer, MD
- Cardiology
In a randomized trial, oral ticagrelor outperformed clopidogrel.
- Reviewing:
- Wallentin L et al. for the PLATO Investigators. N Engl J Med 2009 Sep 10; 361:1045
SUMMARY AND COMMENT
Statins to Prevent Perioperative Cardiovascular Events
- September 3, 2009
- Allan S. Brett, MD
- General Medicine
In high-risk patients, several weeks of statin therapy before vascular surgery led to less ischemia and fewer MIs.
- Reviewing:
- Schouten O et al. N Engl J Med 2009 Sep 3; 361:980
Combination Lipid-Lowering Therapy May Not Be More Effective Than High-Dose Statin MonotherapyFree
- September 1, 2009
- Physician's First Watch
"Limited evidence" suggests that combination lipid-lowering therapy is no more effective than high-dose statin monotherapy for improving clinical outcomes, according to a meta...
SUMMARY AND COMMENT
Statin Reload Beneficial in Percutaneous Coronary Intervention
- August 19, 2009
- Howard C. Herrmann, MD
- Cardiology
The ARMYDA-RECAPTURE results demonstrate that the protective effects of statin loading before PCI extend to ACS patients who are already taking statins.
- Reviewing:
- Di Sciascio G et al. J Am Coll Cardiol 2009 Aug 4; 54:558
