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Entecavir Inhibits HIV at Reduced Viral Inoculum

• Infectious Diseases
• Summary and Comment
• Subscription required

The HBV drug entecavir has anti-HIV activity at a low viral inoculum and shouldn’t be used in HIV/HBV-coinfected patients who are not receiving combination ART.

• By Lynn L. Estes, PharmD
• May 14, 2008
• Covering Antimicrob Agents Chemother 2008 May

Individualization of Treatment Duration in Genotype 1 HCV-Positive Patients

• Gastroenterology
• Summary and Comment
• Subscription required

Is it time to stop treating all HCV-positive patients the same way?

• By Atif Zaman, MD, MPH
• April 4, 2008
• Covering Hepatology 2008 Jan

Pentoxifylline for Severe Alcoholic Hepatitis

• Gastroenterology
• Summary and Comment
• Subscription required

Patients with severe alcoholic hepatitis who do not respond to corticosteroids gain no benefit from switching to pentoxifylline.

• By Atif Zaman, MD, MPH
• March 28, 2008
• Covering J Hepatol 2008 Mar

Telbivudine vs. Adefovir for Chronic HBV

• Gastroenterology
• Summary and Comment
• Subscription required

Telbivudine showed greater antiviral effects than did adefovir after 24 weeks of treatment in patients with chronic HBV infections.

• By Atif Zaman, MD, MPH
• March 21, 2008
• Covering Ann Intern Med 2007 Dec 4

HCV/HIV: Good News, Continued Challenges

• HIV/AIDS
• Meeting Report
• Subscription required

Data from the 15th Retrovirus Conference addressed numerous questions around HCV treatment in HIV-coinfected patients.

• By Rajesh T. Gandhi, MD
• March 10, 2008

Extended Interferon Therapy in HCV-Positive Slow Responders

• Gastroenterology
• Summary and Comment
• Subscription required

Sustained virologic response was significantly higher among slow responders who were treated with 72 weeks of pegylated interferon plus ribavirin.

• CME

• By Atif Zaman, MD, MPH
• March 7, 2008
• Covering Hepatology 2007 Dec

Outcomes of HCV Screening in a High-Risk Population

• Gastroenterology
• Summary and Comment
• Subscription required

Nearly one half of all veterans who were found to have chronic HCV infections in a targeted screening program were considered to be candidates for treatment.

• CME

• By Atif Zaman, MD, MPH
• February 29, 2008
• Covering Am J Gastroenterol 2008 Jan

Chronic HBV Infection with Persistently Normal ALT Levels

• Gastroenterology
• Summary and Comment
• Subscription required

Researchers find marked histologic damage in HBV-infected patients with persistently normal alanine aminotransferase levels.

• CME

• By Atif Zaman, MD, MPH
• February 22, 2008
• Covering J Hepatol 2007 Dec

Chronic Hepatitis E?

• Infectious Diseases
• Summary and Comment
• Subscription required

Investigators in France provide convincing evidence of chronic HEV infection in organ-transplant recipients.

• By Larry M. Baddour, MD
• February 20, 2008
• Covering N Engl J Med 2008 Feb 21

Prolonged Entecavir vs. Lamivudine for HBV

• Gastroenterology
• Summary and Comment
• Subscription required

Entecavir’s efficacy and resistance profile remained superior to that of lamivudine at 96 weeks.

• By Atif Zaman, MD, MPH
• February 8, 2008
• Covering Gastroenterology 2007 Nov

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