GERD / Peptic Ulcers
The latest information on GERD and peptic ulcers — summaries and comments on acid reflux, esophagitis, H. pylori, proton-pump inhibitors, and more — drawn from across our specialties. Sign up now for monthly e-mail alerts on new content.
SUMMARY AND COMMENT
A Murky Relationship Between GERD and Interstitial Lung Disease
- February 3, 2012
- David A. Johnson, MD
- Gastroenterology
Previous studies document a high prevalence of GERD in patients with idiopathic pulmonary fibrosis but provide no evidence of causality.
- Reviewing:
- Hershcovici T et al. Aliment Pharmacol Ther 2011 Dec; 34:1295
SUMMARY AND COMMENT
PPIs Don't Ease Asthma Symptoms in Children with Severe Asthma and Asymptomatic GERD
- February 2, 2012
- David J. Amrol, MD
- General Medicine
In addition, lansoprazole raised the incidence of adverse events.
- Reviewing:
- Holbrook JT et al. JAMA 2012 Jan 25; 307:373
SUMMARY AND COMMENT
PPIs and CAP, Revisited
- January 18, 2012
- Neil M. Ampel, MD
- Infectious Diseases
In a retrospective, nested case-control study, the risk for community-acquired pneumonia was 29% higher with current use of a proton-pump inhibitor than with past use.
- Reviewing:
- Hermos JA et al. Clin Infect Dis 2012 Jan 1; 54:33
SUMMARY AND COMMENT
A New Four-Drug Regimen for H. pylori Infection?
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Eradication was better than with standard triple therapy.
- Reviewing:
- Basu PP et al. Am J Gastroenterol 2011 Nov; 106:1970
SUMMARY AND COMMENT
Sequential Therapy Bests Triple Therapy for H. pylori Infection
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Eradication rates were higher; adverse events were similar.
- Reviewing:
- Kim YS et al. Aliment Pharmacol Ther 2011 Nov; 34:1098
SUMMARY AND COMMENT
Diagnosing Gastroenterological Causes of Noncardiac Chest PainFree
- December 22, 2011
- David A. Johnson, MD
- Gastroenterology
Endoscopy and pH tests should be used to confirm GERD status to guide decisions on treatment with PPIs and the need for further diagnostic testing. CME
- Reviewing:
- Kahrilas PJ et al. Gut 2011 Nov; 60:1473
SUMMARY AND COMMENT
A New Way to Assess Risk in Upper Gastrointestinal Bleeding?
- December 9, 2011
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
An assessment of five readily available measures in emergency settings could improve patient triage and outcomes. CME
- Reviewing:
- Saltzman JR et al. Gastrointest Endosc 2011 Dec; 74:1215
SUMMARY AND COMMENT
Gastrointestinal Bleeding with Low-Dose Aspirin
- November 18, 2011
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
A meta-analysis supports evidence of increased risk for GI bleeding from low-dose aspirin alone and in combination with clopidogrel or anticoagulants.
- Reviewing:
- Lanas A et al. Clin Gastroenterol Hepatol 2011 Sep; 9:762
SUMMARY AND COMMENT
Can Celecoxib or Helicobacter pylori Eradication Reduce Gastric Lesions?
- November 4, 2011
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Regression of precancerous lesions was better with either treatment than with placebo.
- Reviewing:
- Wong BCY et al. Gut 2011 Sep 13
SUMMARY AND COMMENT
Predictors of Rebleeding After Endoscopic Therapy for Peptic Ulcers
- November 4, 2011
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Risk factors were hemodynamic instability, a low hemoglobin value, active bleeding, large ulcer size, and an ulcer in the posterior duodenum or high on the lesser gastric curve. CME
- Reviewing:
- García-Iglesias P et al. Aliment Pharmacol Ther 2011 Oct; 34:888
