GERD / Peptic Ulcers
The latest information on GERD and peptic ulcers — summaries and comments on acid reflux, esophagitis, H. pylori, proton-pump inhibitors, and more — drawn from across our specialties. Sign up now for monthly e-mail alerts on new content.
SUMMARY AND COMMENT
Blood Type and Nonvariceal Upper GI Bleeding
An association between blood type O and nonvariceal upper gastrointestinal bleeding is not sufficient to imply causation.
- Reviewing:
- Bayan K et al. Dig Dis Sci 2009 May; 54:1029
SUMMARY AND COMMENT
Safety of PPIs in Pregnancy
- June 18, 2009
- Allan S. Brett, MD
- General Medicine
PPI use was not associated with congenital malformations.
- Reviewing:
- Gill SK et al. Am J Gastroenterol 2009 Jun; 104:1541
SUMMARY AND COMMENT
Arterial Embolization for Bleeding Peptic Ulcers
Coagulopathy and the use of coils alone for embolization are independently associated with rebleeding.
- Reviewing:
- Loffroy R et al. Clin Gastroenterol Hepatol 2009 May; 7:515
SUMMARY AND COMMENT
PPIs and Pneumonia, Revisited
- June 3, 2009
- Richard T. Ellison III, MD
- Infectious Diseases
Among non–critically ill inpatients, PPI therapy was associated with a 30% increase in risk for hospital-acquired pneumonia.
- Reviewing:
- Herzig SJ et al. JAMA 2009 May 27; 301:2120
SUMMARY AND COMMENT
Higher Mortality for Weekend AUGIB Admissions
Patients admitted on weekends with peptic ulcer–related and nonvariceal acute upper gastrointestinal bleeding also had longer hospital stays and higher medical costs.
- Reviewing:
- Shaheen AAM et al. Clin Gastroenterol Hepatol 2009 Mar; 7:303
SUMMARY AND COMMENT
Predicting Mortality in Patients with Bleeding Ulcers
Investigators developed a prediction model for ulcer-related mortality after endoscopic therapy.
- Reviewing:
- Chiu PW et al. Clin Gastroenterol Hepatol 2009 Mar; 7:311
SUMMARY AND COMMENT
PPI Lowers Rate of Recurrent Peptic Ulcer Bleeding
- May 5, 2009
- Richard Saitz, MD, MPH, FACP, FASAM
- General Medicine
The incidence of clinically significant recurrent bleeding was lower with esomeprazole than with placebo.
- Reviewing:
- Sung JJY et al. Ann Intern Med 2009 Apr 7; 150:455
SUMMARY AND COMMENT
PPI Treatment for Acute GI Bleeding from Peptic Ulcer
Three days of IV PPI therapy reduced rebleeding for up to 30 days but did not affect mortality.
- Reviewing:
- Sung JJY et al. Ann Intern Med 2009 Apr 7; 150:455
SUMMARY AND COMMENT
Esophagitis and Its Connection with GERD and EoE
- April 17, 2009
- David A. Johnson, MD
- Gastroenterology
Recent study findings suggest that elevated fibroblast growth factor 9 production in response to esophagitis is evident in both GERD and eosinophilic esophagitis.
- Reviewing:
- Mulder DJ et al. Gut 2009 Feb; 58:166
SUMMARY AND COMMENT
Risk Factors for Bleeding Peptic Ulcers
- April 10, 2009
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Data from a small study showed no interaction between H. pylori infection and NSAID use in the risk for bleeding ulcers.
- Reviewing:
- Uppalapati SS et al. Dig Dis Sci 2009 Mar; 54:593
