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Oncology and Hematology Editor's Picks
SUMMARY AND COMMENT
Polymorphisms in CTLA4 Confer Susceptibility to Nonmelanoma Skin CancersFree
- September 25, 2009
- Craig A. Elmets, MD
- Dermatology
A genetic variant that confers excess risk for autoimmune disease may also protect against nonmelanoma skin cancers.
- Reviewing:
- Welsh MM et al. Cancer Res 2009 Aug 1; 69:6158
SUMMARY AND COMMENT
Warfarin for Stroke Prevention in Patients with Atrial Fibrillation
- September 16, 2009
- Joel M. Gore, MD
- Cardiology
Results of a large observational study provide current data for accurate risk-benefit estimation.
- Reviewing:
- Singer DE et al. Ann Intern Med 2009 Sep 1; 151:297
SUMMARY AND COMMENT
Overdiagnosis in PSA Screening
- September 24, 2009
- Allan S. Brett, MD
- General Medicine
An analysis suggests that many men have been treated unnecessarily because of PSA screening.
- Reviewing:
- Welch HG and Albertsen PC. J Natl Cancer Inst 2009 Aug 31
SUMMARY AND COMMENT
An Alternative to Warfarin in Patients with Atrial Fibrillation?
- September 1, 2009
- Harlan M. Krumholz, MD, SM
- Cardiology
Compared with warfarin, low-dose dabigatran performed better with regard to safety but not efficacy, and high-dose dabigatran performed better with regard to efficacy but not safety.
- Reviewing:
- Connolly SJ et al. for the RE-LY Steering Committee and Investigators. N Engl J Med 2009 Aug 30
SUMMARY AND COMMENT
Refining Antiplatelet Treatment in Patients with Acute Coronary Syndromes
- September 2, 2009
- Beat J. Meyer, MD
- Cardiology
In a randomized trial, oral ticagrelor outperformed clopidogrel.
- Reviewing:
- Wallentin L et al. for the PLATO Investigators. N Engl J Med 2009 Sep 10; 361:1045
SUMMARY AND COMMENT
Photodynamic Therapy and the Immune System
- August 14, 2009
- Craig A. Elmets, MD
- Dermatology
PDT apparently increases antitumor immunity in addition to directly destroying lesions of basal cell carcinoma.
- Reviewing:
- Kabingu E et al. Clin Cancer Res 2009 Jul 1; 15:4460
SUMMARY AND COMMENT
Ovarian Status and Risk for Lung Cancer
- September 3, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Further evidence that functional ovaries protect against lung cancer
- Reviewing:
- Koushik A et al. Int J Cancer 2009 May 11
SUMMARY AND COMMENT
Non–AIDS-Defining Cancer Is More Common in HIV-Infected Than in HIV-Uninfected Men
- August 10, 2009
- Keith Henry, MD
- HIV/AIDS Clinical Care
In the U.S. VA Healthcare System, the incidence of non–AIDS-defining malignancies was 60% higher in HIV-infected patients than in matched HIV-uninfected patients.
- Reviewing:
- Bedimo RJ et al. J Acquir Immune Defic Syndr 2009 Jul 16
SUMMARY AND COMMENT
Aspirin Lengthens Survival in Patients with Nonmetastatic Colorectal Cancer
- September 1, 2009
- Anthony L. Komaroff, MD
- General Medicine
Starting regular aspirin therapy after colorectal cancer diagnosis was associated with lower mortality during 12 years. Interview
- Reviewing:
- Chan AT et al. JAMA 2009 Aug 12; 302:649
SUMMARY AND COMMENT
Trimming the HedgehogFree
- September 2, 2009
- Hensin Tsao, MD, PhD
- Dermatology
A novel inhibitor of the hedgehog signaling pathway had promising results in patients with metastatic and aggressive local BCCs.
- Reviewing:
- Von Hoff DD et al. N Engl J Med 2009 Sep 2
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