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Neurology Editor's Picks
SUMMARY AND COMMENT
CNS Penetration of ART and Cognitive Performance: An Unexpected Finding
- June 8, 2009
- Jennifer Johnson, MD, and Paul E. Sax, MD
- HIV/AIDS Clinical Care
Increased CNS penetration effectiveness of the ART regimen was associated with poorer neurocognitive outcomes, despite increased rates of CSF viral suppression.
- Reviewing:
- Marra CM et al. AIDS 2009 May 6
SUMMARY AND COMMENT
AmB plus Fluconazole for Cryptococcal Meningitis?
- June 17, 2009
- Neil M. Ampel, MD
- Infectious Diseases
In a randomized phase II study, treatment success was more likely with amphotericin B plus fluconazole than with amphotericin B alone.
- Reviewing:
- Pappas PG et al. Clin Infect Dis 2009 Jun 15; 48:1775
SUMMARY AND COMMENT
Botox for Raynaud PhenomenonFree
- July 17, 2009
- George J. Hruza, MD
- Dermatology
Results of this treatment were surprisingly long lasting.
- Reviewing:
- Neumeister MW et al. Plast Reconstr Surg 2009 Jul; 124:191
SUMMARY AND COMMENT
Need for Lumbar Puncture in Children with Simple Febrile Seizure
- February 4, 2009
- Howard Bauchner, MD
- Pediatrics and Adolescent Medicine
The decision to perform lumbar puncture in a child with a simple febrile seizure should depend more on the history and physical examination than just on the age of the patient.
- Reviewing:
- Kimia AA et al. Pediatrics 2009 Jan; 123:6
SUMMARY AND COMMENT
The ABCs of Pneumococcal Meningitis Prevention
- January 14, 2009
- Larry M. Baddour, MD
- Infectious Diseases
PCV7 is effective in reducing rates of pneumococcal meningitis in both children and adults.
- Reviewing:
- Hsu HE et al. N Engl J Med 2009 Jan 15; 360:244
SUMMARY AND COMMENT
Desmoteplase Shows No Benefit for Treatment of Ischemic Stroke
- January 16, 2009
- Kristi L. Koenig, MD, FACEP
- Emergency Medicine
When given within 3 to 9 hours after symptom onset, IV desmoteplase was no better than placebo.
- Reviewing:
- Hacke W et al. Lancet Neurol 2008 Dec 25
SUMMARY AND COMMENT
New Class of Drugs for Acute MigraineFree
- January 16, 2009
- Kristi L. Koenig, MD, FACEP
- Emergency Medicine
Telcagepant, a calcitonin gene-related peptide antagonist, is as effective as zolmitriptan, with fewer adverse effects.
- Reviewing:
- Ho TW et al. Lancet 2008 Dec 20; 372:2115
SUMMARY AND COMMENT
In Utero Exposure to Valproate: A Cause of Autism?
- January 7, 2009
- Martin T. Stein, MD
- Pediatrics and Adolescent Medicine
Preliminary findings from this small study represent the first prospective observation of an association between fetal valproate exposure and ASDs.
- Reviewing:
- Bromley RL et al. Neurology 2008 Dec 2; 71:1923
SUMMARY AND COMMENT
For Cryptococcal Meningitis, Is More Fluconazole Better?
- December 17, 2008
- Neil M. Ampel, MD
- Infectious Diseases
Among HIV-infected patients in Uganda, cryptococcal infection was cleared more rapidly with 1200 mg daily than with 800 mg daily.
- Reviewing:
- Longley N et al. Clin Infect Dis 2008 Dec 15; 47:1556
SUMMARY AND COMMENT
Silver Lining for Women with Migraines?
- December 18, 2008
- Andrew M. Kaunitz, MD
- Women's Health
History of migraine was associated with lower risk for breast cancer.
- Reviewing:
- Mathes RW et al. Cancer Epidemiol Biomarkers Prev 2008 Nov; 17:3116
