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Infectious Diseases Editor's Picks
DRUG WATCH
Should Efavirenz Be Dosed Higher When Coadministered with Rifampin?Free
- February 6, 2012
- Tanuja N. Gengiah, M Clin Pharm, MS (Epi), and Salim S. Abdool Karim, MD, PhD
- HIV/AIDS Clinical Care
The FDA recommends a dosage increase in patients weighing 
50 kg, but data on the interaction between these drugs are inconsistent.
SUMMARY AND COMMENT
Testing Midstream Urine for Chlamydia trachomatis
- February 2, 2012
- Anna Wald, MD, MPH
- Women's Health
Midstream samples might be adequate for evaluating both chlamydial and urinary tract infections, but study results were not definitive.
- Reviewing:
- Mangin D et al. Ann Fam Med 2012 Jan/Feb; 10:50
SUMMARY AND COMMENT
Cumulative PI Exposure and Risk for Sudden Death or Nonhemorrhagic Stroke
- January 30, 2012
- Keith Henry, MD
- HIV/AIDS Clinical Care
A modest association was seen, but too few events occurred for the results to be considered definitive.
- Reviewing:
- Worm SW et al. J Infect Dis 2012 Feb 15; 205:535
SUMMARY AND COMMENT
Oral and Fingerstick Sample Collection for HIV Screening: Subtle but Important Differences in Accuracy
- January 30, 2012
- Rochelle P. Walensky, MD, MPH
- HIV/AIDS Clinical Care
The OraQuick rapid HIV test performed well on both types of samples but was less sensitive and specific on oral fluid, which would lead to a lower positive predictive value in low-prevalence settings.
- Reviewing:
- Pai NP et al. Lancet Infect Dis 2012 Jan 24
SUMMARY AND COMMENT
HIV Viral Loads — the Lower, the Better?Free
- January 30, 2012
- Helmut Albrecht, MD
- HIV/AIDS Clinical Care
Patients with low-level viremia on sensitive assays have an increased risk for virologic failure, but the optimal management of such patients remains unclear.
- Reviewing:
- Doyle T et al. Clin Infect Dis 2012 Jan 11
SUMMARY AND COMMENT
Even at High CD4-Cell Counts, Mortality Rates Are High in Untreated HIV InfectionFree
- January 13, 2012
- Mauro Schechter, MD, PhD
- HIV/AIDS Clinical Care
An observational study from Côte d'Ivoire supports earlier treatment initiation, particularly in sub-Saharan Africa.
- Reviewing:
- Anglaret X et al. Clin Infect Dis 2011 Dec 14
SUMMARY AND COMMENT
Helium-Oxygen Therapy Improves Bronchiolitis Scores in Infants Receiving Nebulized Epinephrine
- January 20, 2012
- Katherine Bakes, MD
- Emergency Medicine
Improvement was noted on each of two validated severity scores.
- Reviewing:
- Kim IK et al. Arch Pediatr Adolesc Med 2011 Dec; 165:1115
SUMMARY AND COMMENT
FCGR2A as a Susceptibility Locus for Kawasaki Disease
- January 20, 2012
- Kenneth Y. Tsai, MD, PhD
- Dermatology
A genome-wide association study points to a susceptibility locus linking Kawasaki disease to an immune mediator.
- Reviewing:
- Khor CC et al. Nat Genet 2011 Nov 13; 43:1241
SUMMARY AND COMMENT
Is HIV Becoming More Virulent?
- January 13, 2012
- Helmut Albrecht, MD
- HIV/AIDS Clinical Care
A meta-analysis suggests that over the course of the epidemic, the mean virologic set point of HIV-infected patients has been increasing and the mean baseline CD4-cell count has been decreasing.
- Reviewing:
- Herbeck JT et al. AIDS 2012 Jan 14; 26:193
SUMMARY AND COMMENT
Estimating HPV Transmission Rates
- January 10, 2012
- Abigail Zuger, MD
- General Medicine
In a college-age crowd, heterosexual transmission was considerable.
- Reviewing:
- Burchell AN et al. J Infect Dis 2011 Dec 1; 204:1723
