Breast Cancer
The latest information on BRCA, chemotherapy, mammography, mastectomy, and more, drawn from across our primary care and specialty care areas. Sign up now for monthly e-mail alerts on new content.
SUMMARY AND COMMENT
Younger Breast Cancer Survivors Have Unique Concerns
- February 2, 2012
- Andrew M. Kaunitz, MD
- Women's Health
A systematic review focuses on quality of life, emotional health, and menopause- and fertility-related issues in survivors age 50 or younger.
- Reviewing:
- Howard-Anderson J et al. J Natl Cancer Inst. 2012 Jan 23
SUMMARY AND COMMENT
New Insights into the Biology of Metastasis
- January 31, 2012
- Anthony L. Komaroff, MD
- General Medicine
Cancer stem cells and endothelial signaling might point to novel therapies.
- Reviewing:
- Malanchi I et al. Nature 2012 Jan 5; 481:85
The 2011 San Antonio Breast Cancer SymposiumFree
- January 24, 2012
- William J. Gradishar, MD
- Oncology and Hematology
Highlights include adjuvant bisphosphonates, endocrine therapy, treatment of HER2-positive breast cancer, and genomic scores for predicting risk for recurrence of ductal carcinoma in situ.
SUMMARY AND COMMENT
Dual Antibodies Reap Benefits Against HER2-Positive Metastatic Breast Cancer
- January 24, 2012
- William J. Gradishar, MD
- Oncology and Hematology
Adding pertuzumab to trastuzumab plus docetaxel prolonged progression-free survival without raising risk for cardiac events.
- Reviewing:
- Baselga J et al. N Engl J Med 2012 Jan 12; 366:109
SUMMARY AND COMMENT
Adjuvant Radiation Therapy for Breast Cancer Affects Coronary Arteries
- January 24, 2012
- William J. Gradishar, MD
- Oncology and Hematology
Stenosis occurred in certain regions of the arterial tree, but contemporary RT has evolved to minimize this risk.
- Reviewing:
- Nilsson G et al. J Clin Oncol 2011 Dec 27
SUMMARY AND COMMENT
Biopsy of Recurrent Breast Cancer Can Tell an Important Story
- January 10, 2012
- William J. Gradishar, MD
- Oncology and Hematology
Marker discordance between primary and metastatic tumors affects management decisions and patients' outcomes.
- Reviewing:
- Amir E et al. J Clin Oncol 2011 Nov 28
SUMMARY AND COMMENT
Breast Cancer Prognosis and Management: Role of Gene Expression Profiling
- January 10, 2012
- Virginia Kaklamani, MD, DSc
- Oncology and Hematology
Molecular signatures are increasingly important for guiding treatment recommendations.
- Reviewing:
- Reis-Filho JS and Pusztai L. Lancet 2011 Nov 19; 378:1812
SUMMARY AND COMMENT
Another Taxane Doublet for Metastatic Breast Cancer?
- December 6, 2011
- William J. Gradishar, MD
- Oncology and Hematology
Adding gemcitabine to docetaxel did not improve outcomes significantly.
- Reviewing:
- Nielsen DL et al. J Clin Oncol 2011 Nov 14
SUMMARY AND COMMENT
Will Axillary Radiotherapy Replace Axillary Dissection in Women with Positive Sentinel Nodes?
- November 29, 2011
- Henry Mark Kuerer, MD, PhD, FACS
- Oncology and Hematology
For management of early breast cancer, sufficiency of local therapy must be balanced against risk for overtreatment.
- Reviewing:
- Haffty BG et al. J Clin Oncol 2011 Oct 31
SUMMARY AND COMMENT
Detection Rates Are Similar for Digital and Film MammographyFree
- November 17, 2011
- Jamaluddin Moloo, MD, MPH
- General Medicine
Digital mammography had better sensitivity when breast tissue was dense.
- Reviewing:
- Kerlikowske K et al. Ann Intern Med 2011 Oct 18; 155:493
