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Lapatinib for Treatment of Metastatic Brain Metastases
- Oncology and Hematology
- Summary and Comment
- Subscription required
This antitumor agent failed to provide a predefined CNS response, but its use was associated with volumetric reductions in target lesions.
- By William J. Gradishar, MD
- May 13, 2008
- Covering J Clin Oncol 2008 Apr 20
Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer
- Oncology and Hematology
- Summary and Comment
- Subscription required
Frequent paclitaxel therapy, but not docetaxel therapy, benefitted women with HER2-positive or HER2-negative tumors.
- By William J. Gradishar, MD
- May 13, 2008
- Covering N Engl J Med 2008 Apr 17
Pharmacogenomics, CYP2D6, and Adjuvant Endocrine Therapy
- Oncology and Hematology
- Summary and Comment
- Subscription required
CYP2D6 genotype data could help tailor hormonal therapy for postmenopausal breast cancer patients.
- By William J. Gradishar, MD
- May 13, 2008
- Covering J Natl Cancer Inst 2008 May 7
More Data on Aromatase Inhibitors for Breast Cancer
- General Medicine
- Summary and Comment
- Subscription required
Extending endocrine therapy beyond 5 years prevents some breast cancer relapses.
- By Allan S. Brett, MD
- May 8, 2008
- Covering J Clin Oncol 2008 Apr 20
Questions Remain About Hormone Therapy and Risk for Breast Cancer Recurrence
- Women's Health
- Summary and Comment
- Subscription required
Conflicting findings from two European randomized clinical trials
- By Andrew M. Kaunitz, MD
- May 8, 2008
- Covering J Natl Cancer Inst 2008 Apr 2
Megestrol for Hot Flashes in Breast Cancer Survivors
- Women's Health
- Summary and Comment
- Subscription required
Results of a 6-month trial confirmed efficacy, but safety questions remain.
- By Andrew M. Kaunitz, MD
- May 8, 2008
- Covering J Clin Oncol 2008 Apr 1
Stopping Trials Early for Benefit — Too Good to Be True?
- General Medicine
- Summary and Comment
- Subscription required
Be skeptical of results from trials stopped early for benefit.
- By Paul S. Mueller, MD, MPH, FACP
- May 1, 2008
- Covering Ann Oncol 2008 Apr 9
Aromatase Inhibitors in Preventing Breast Cancer Recurrence After 5 Years of Tamoxifen
- Women's Health
- Summary and Comment
- Subscription required
In women with hormone receptor–positive breast cancer who have completed therapy with tamoxifen, adjuvant therapy with an aromatase inhibitor improved disease-free survival.
- By Andrew M. Kaunitz, MD
- May 1, 2008
- Covering J Clin Oncol 2008 Apr 20
Radiation Therapy for Breast Cancer: Are Fewer Fractions Better?
- Women's Health
- Summary and Comment
- Subscription required
British trial results favored fewer fractions, higher doses per fraction, and fewer weeks of radiation therapy for early breast cancer; longer follow-up is needed.
- By Andrew M. Kaunitz, MD
- May 1, 2008
- Covering Lancet Oncol 2008 Apr
Hormone Therapy in Breast Cancer Survivors
- General Medicine
- Summary and Comment
- Subscription required
Hormone therapy in this population raises risk for recurrence.
- By Allan S. Brett, MD
- April 24, 2008
- Covering J Natl Cancer Inst 2008 Apr 2