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Search for thrombolytic therapy in all Journal Watch editions
Physician-authored summaries on the latest research on thrombolytic therapy, editorials on thrombolytic therapy, and perspectives on thrombolytic therapy - drawn from the top medical journals.
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You searched for: thrombolytic therapy
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Thrombolytic Therapy: Not for Uncomplicated PE
- December 12, 2008
- J. Stephen Bohan, MD, MS, FACP, FACEP
- Emergency Medicine
Patients without hemodynamic compromise had higher mortality rates when they were given thrombolytic therapy.- Reviewing:
- Ibrahim SA et al., Arch Intern Med 2008 Nov 10; 168:2183. Brotman DJ and Streiff MB., [invited commentary] 2008 Nov 10; 168:2191.
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Thrombolysis for Stroke Within 4.5 Hours Is Safe and Effective Free
- September 24, 2008
- J. Stephen Bohan, MD, MS, FACP, FACEP
- Emergency Medicine
But still, the sooner treatment is administered, the better!- Reviewing:
- Hacke W et al. for the ECASS Investigators., N Engl J Med 2008 Sep 25; 359:1317. Lyden P., N Engl J Med 2008 Sep 25; 359:1393.
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New Guidelines on Antithrombotic Therapy Are Here!
- July 17, 2008
- Allan S. Brett, MD
- General Medicine
The eighth edition of the ACCP guidelines provides wide-ranging recommendations.- Reviewing:
- Hirsh J et al., Chest 2008 Jun; 133:110.
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Rescue Angioplasty in ST-Segment–Elevation MI?
- February 14, 2006
- Kirsten E. Fleischmann, MD, MPH
- General Medicine
Rescue angioplasty results in better outcomes than repeat thrombolysis or conservative treatment in STEMI patients without electrocardiographic evidence of reperfusion.- Reviewing:
- Gershlick AH et al., N Engl J Med 2005 Dec 29; 353:2758-68.
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Guidelines on Antithrombotic and Thrombolytic Therapy for Stroke
- January 27, 2005
- Justin A. Zivin, MD, PhD
- Neurology
These guidelines are worth the challenge of reading them.- Reviewing:
- Albers GW et al., Chest 2004 Sep; 126:483S-512S.
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Immediate Mechanical Reperfusion Benefits STEMI Patients Who Cannot Have Thrombolytic Therapy
- January 6, 2004
- John A. Marx, MD, FACEP
- Emergency Medicine
Recent evidence favors immediate mechanical reperfusion (IMR; percutaneous coronary intervention [PCI] or coronary artery bypass graft [CABG] surgery) over thrombolytic therapy for patients with acute . . .- Reviewing:
- Grzybowski M et al., JAMA 2003 Oct 8; 290::1891-8..
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Confirmation That PCI Is Superior to Thrombolytic Therapy for AMI
- February 26, 2003
- James M. Christenson, MD, FRCPC
- Emergency Medicine
Although PTCA is favored over immediate thrombolytic therapy in many centers, questions about the benefit in certain patient subgroups and over the long term remain . . .- Reviewing:
- Grines C et al., Am Heart J 2003 Jan; 145:47-57.
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Further Confirmation That PCI Is Superior to Thrombolytic Therapy for AMI
- February 26, 2003
- James Scott, MD
- Emergency Medicine
Several individual studies and systematic reviews have demonstrated a small but significant advantage of primary PTCA over intravenous thrombolytic therapy in patients with acute MI. . . .- Reviewing:
- Keeley EC et al., Lancet 2003 Jan 4; 361:13-20.
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PTCA Is More Effective than Thrombolytic Therapy for MI
- February 11, 2003
- Sir Brian Jarman, PhD, FRCP, FRCGP, FFPHM, FMedSci
- General Medicine
In the early 1980s, researchers showed that thrombolytic therapy reduces morbidity and mortality in patients who suffer myocardial infarctions. More recently, percutaneous transluminal coronary angioplasty . . .- Reviewing:
- Keeley EC et al., Lancet 2003 Jan 4; 361:13-20.
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Primary Angioplasty or Thrombolytic Therapy for Elderly Patients with MI?
- July 23, 2002
- Kirsten E. Fleischmann, MD, MPH
- General Medicine
Risk for the composite of death, reinfarction, and stroke was significantly lower among patients who underwent angioplasty than among those who received thrombolysis.- Reviewing:
- de Boer M-J et al., J Am Coll Cardiol 2002 Jun 5; 39:1723-8. Thiemann DR., J Am Coll Cardiol 2002 Jun 5; 39:1729-32.
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PCI Superior to Thrombolytic Therapy at Community Hospitals
- June 26, 2002
- John A. Marx, MD, FACEP
- Emergency Medicine
Randomized trials of primary percutaneous coronary interventions (PPCIs) versus thrombolytic therapy (TT) for patients with acute myocardial infarction (AMI) and a recent meta-analysis proclaimed the . . .- Reviewing:
- Aversano T et al., JAMA 2002 Apr 17; 287:1943-51.
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Bleeding Complications with Abciximab After Failed Thrombolytic Therapy
- May 4, 2001
- JM Gore
- Cardiology
In patients who undergo coronary angioplasty, intravenous administration of glycoprotein (GP) IIb/IIIa antagonists such as abciximab has become routine because of its ability to reduce . . .- Reviewing:
- Cantor WJ et al., Am J Cardiol 2001 Feb 15; 87:
439 442 .
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Is Non-Q-Wave MI After Thrombolytic Therapy an Indication for Angiography?
- February 9, 2001
- KE Fleischmann
- General Medicine
Patients treated with thrombolytic therapy who subsequently suffer non-Q-wave myocardial infarction often undergo coronary angiography and revascularization because they are considered to be at high . . .- Reviewing:
- Wexler LF et al., J Am Coll Cardiol 2001 Jan; 37:
19 25 . Chaitman BR and Bitar SR., J Am Coll Cardiol 2001 Jan; 37:26 29 .
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Long-Term Benefit of Primary PTCA vs. Thrombolytic Therapy
- December 10, 1999
- HM Krumholz
- Cardiology
Randomized trials have indicated that during the first weeks after acute MI, primary percutaneous transluminal coronary angioplasty is associated with lower rates of death, nonfatal . . .- Reviewing:
- Zijlstra F et al., N Engl J Med 1999 Nov 4; 341:
1413 1419 .
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Review Supports Thrombolytic Therapy for Stroke
- October 1, 1999
- CV Pollack
- Emergency Medicine
Intravenous thrombolytic therapy with t-PA for the treatment of acute ischemic stroke is approved by the U.S. FDA. Many physicians consider thrombolytic therapy to be . . .- Reviewing:
- Osborn TM et al., Ann Emerg Med 1999 Aug; 34:
244 255 .
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Update on Thrombolytic Therapy for PE
- August 1, 1999
- CV Pollack
- Emergency Medicine
In many cases, thrombolytic therapy is superior to anticoagulation therapy for acute pulmonary embolism with cardiovascular compromise. Emergency physicians are often faced with the decision . . .- Reviewing:
- Arcasoy SM and Kreit JW., Chest 1999 Jun; 115:
1695 1707 .
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More on Thrombolytic Therapy for Strokes.
- October 30, 1998
- B Jarman
- General Medicine
There is ongoing debate about the benefits and risks of thrombolytic therapy for acute ischemic strokes. Trials with IV streptokinase were terminated because of increased . . .- Reviewing:
- Hacke W et al., Lancet 1998 Oct 17; 352:
1245 1251 . Bath P., Lancet 1998 Oct 17; 352:1238 1239 .
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Thrombolytic Therapy During Menstruation
- April 1, 1998
- HM Krumholz
- Women's Health
Myocardial infarction is uncommon in premenopausal women, but it does occur occasionally. Clinicians are sometimes confronted with deciding whether to use thrombolytic therapy in menstruating . . .- Reviewing:
- Darne RD and Singh S., Can J Cardiol 1998 Feb; 14:
253 254 .
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THROMBOLYTIC THERAPY UNDERUTILIZED AMONG ELDERLY.
- June 20, 1997
- TH Lee
- General Medicine
Thrombolytic therapy is one of the major advances for the treatment of acute myocardial infarction in our time, but not all eligible older patients receive . . .- Reviewing:
- Krumholz HM et al., JAMA 1997 Jun 4; 277:
1683 1688 .
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Worse Outcomes for Women after Thrombolytic Therapy
- April 1, 1996
- SD Gharib
- Women's Health
Thrombolytic therapy for acute myocardial infarction was the big breakthrough of the 1980s and 1990s, but do women fare as well with this treatment as . . .- Reviewing:
- Weaver WD et al., JAMA 1996 Mar 13; 275:
777 782 .
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