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Search for syphilis in all Journal Watch editions
Physician-authored summaries on the latest research on syphilis, editorials on syphilis, and perspectives on syphilis - drawn from the top medical journals.
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You searched for: syphilis
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Syphilis Serology in HIV
- October 22, 2012
- Abigail Zuger, MD
- HIV/AIDS
A retrospective study failed to show much difference between HIV-positive and HIV-negative patients.- Reviewing:
- Knaute DF et al., Clin Infect Dis 2012 Oct 9;:
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Early Syphilis May Greatly Increase HIV Viral Load
- August 20, 2012
- Brian R. Wood, MD
- HIV/AIDS
Syphilis infection was associated with a transient dip in CD4-cell count and a significant increase in HIV viral load, regardless of HIV treatment status.- Reviewing:
- Jarzebowski W et al., Arch Intern Med 2012 Jul 23;:
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When Syphilis Tests Contradict Each Other
- November 22, 2011
- Abigail Zuger, MD
- General Medicine
A third test could help, but uncertainties remain.- Reviewing:
- Park IU et al., J Infect Dis 2011 Nov 1; 204:1297. Hoover KW and Radolf JD., J Infect Dis 2011 Nov 1; 204:1295.
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Young MSM at the Center of the HIV and Syphilis Epidemics
- November 21, 2011
- Sonia Nagy Chimienti, MD
- HIV/AIDS
Two studies — one conducted in New York City and the other nationwide — detail the rising incidence of HIV infection and syphilis among men who have sex with men.- Reviewing:
- Pathela P et al., J Acquir Immune Defic Syndr 2011 Dec 1; 58:408. Torrone EA et al., J Acquir Immune Defic Syndr 2011 Nov 1; 58:328.
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What to Do With Discordant Syphilis Serology Results?
- October 3, 2011
- Timothy J. Henrich, MD
- HIV/AIDS
Available evidence supports confirmatory treponemal-specific testing for patients who have an initial positive syphilis immunoassay followed by a negative RPR result.- Reviewing:
- Park IU et al., J Infect Dis 2011 Sep 19; 204:1297. Hoover KW and Radolf JD., J Infect Dis 2011 Nov 1; 204:1295.
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Syphilis Rates Rising Among Men Who Have Sex with Men
- August 23, 2011
- Jamaluddin Moloo, MD, MPH
- General Medicine
The steepest relative increases were among Hispanic and black teenagers.- Reviewing:
- Su JR et al., Ann Intern Med 2011 Aug 2; 155:145.
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Testing for Syphilis Free
- March 2, 2011
- Richard T. Ellison III, MD
- Infectious Diseases
Reversing the sequence of screening tests has improved case identification but — in low-prevalence populations — has increased the likelihood of false-positive results.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Feb 11; 60:133. Mishra S et al., Sex Transm Dis 2011 Mar; 38:190.
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Web-Based Partner Notification for Syphilis Free
- August 11, 2010
- Richard T. Ellison III, MD
- Infectious Diseases
Expanding syphilis case management to the Internet substantially increased the number of sex partners who were notified.- Reviewing:
- Ehlman DC et al., Sex Transm Dis 2010 Aug; 37:478.
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Syphilis Simmers Down
- August 9, 2010
- Abigail Zuger, MD
- HIV/AIDS
Most of the identified cases in a large screened population were asymptomatic.- Reviewing:
- Thurnheer MC et al., AIDS 2010 Jul 31; 24:1907.
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Treating Syphilis Without Penicillin Free
- June 17, 2010
- Abigail Zuger, MD
- General Medicine
A large study finds that a single oral dose of azithromycin can be curative in patients with early syphilis.- Reviewing:
- Hook EW III et al., J Infect Dis 2010 Jun 1; 201:1729.
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Azithromycin for Early Syphilis?
- May 5, 2010
- Larry M. Baddour, MD
- Infectious Diseases
In patients without HIV infection, 2 g of oral azithromycin was as efficacious as benzathine penicillin G for treatment of early syphilis.- Reviewing:
- Hook EW III et al., J Infect Dis 2010 Jun 1; 201:1729.
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Recent Trends in Congenital Syphilis and Herpes Simplex Virus Prevalence
Rates of congenital syphilis are rising; HSV rates are stable but still worrisome.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2010 Apr 16; 59:413. Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2010 Apr 23; 59:456.
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Doxycycline or Tetracycline for Primary Syphilis
- October 15, 2008
- Neil M. Ampel, MD
- Infectious Diseases
In a retrospective study, serologic success rates were 97% with benzathine penicillin and 100% with doxycycline or tetracycline.- Reviewing:
- Wong T et al., Am J Med 2008 Oct; 121:903.
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Has Your Lab Changed Its Syphilis Testing Protocol?
- September 16, 2008
- Abigail Zuger, MD
- General Medicine
If so, you might be facing an unfamiliar decision tree.- Reviewing:
- CDC., MMWR Morb Mortal Wkly Rep 2008 Aug 15; 57:872.
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A New Wrinkle in Syphilis Testing
- August 27, 2008
- Stephen G. Baum, MD
- Infectious Diseases
Reversal of the traditional syphilis screening test algorithm reveals cases that would have been missed before.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2008 Aug 15; 57:872.
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HIV Incidence Among Men with Early Syphilis: A Tale of Three Cities
- January 18, 2008
- Sonia Nagy Chimienti, MD
- HIV/AIDS
Among men diagnosed with early syphilis at STD clinics in Atlanta, Los Angeles, and San Francisco, HIV incidence was estimated to be 9.5% per year overall and 12.0% per year for MSM.- Reviewing:
- Buchacz K et al., J Acquir Immune Defic Syndr 2007 Dec 20;:
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Syphilis Resurges in China
- February 7, 2007
- Mary E. Wilson, MD
- Infectious Diseases
The incidence of syphilis in China increased 38-fold between 1993 and 1999, with the greatest increase seen in congenital syphilis.- Reviewing:
- Chen ZQ et al., Lancet 2007 Jan 13; 369:132-8. Fisman DN., Lancet 2007 Jan 13; 369:84-5.
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Blurred Vision in HIV-Infected Patients: Think Ocular Syphilis
- May 19, 2006
- Neil M. Ampel, MD
- Infectious Diseases
Over a 13-month period in one clinic, ocular syphilis was diagnosed in three patients taking potent ART.- Reviewing:
- Balba GP et al., Am J Med 2006 May; 119:448.e21-5.
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Azithromycin Might Cure Early Syphilis, but Beware of Failure
- October 11, 2005
- Abigail Zuger, MD
- General Medicine
Benzathine penicillin has been the treatment of choice for early-stage syphilis for 50 years. Although drug resistance has never hampered its efficacy, alternative treatments are . . .- Reviewing:
- Riedner G et al., N Engl J Med 2005 Sep 22; 353:1236-44. Holmes KK., N Engl J Med 2005 Sep 22; 353:1291-3.
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Epidemic Cycling of Syphilis
- February 28, 2005
- Bradley E. Britigan, MD
- Infectious Diseases
Periodic increases in the incidence of syphilis are often attributed to social and behavioral changes in the populations affected and trigger public health measures aimed . . .- Reviewing:
- Grassly NC et al., Nature 2005 Jan 27; 433:417-21.
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