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Search for statins in all Journal Watch editions
Physician-authored summaries on the latest research on statins, editorials on statins, and perspectives on statins - drawn from the top medical journals.
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You searched for: statins
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Continuing Statins May Improve Early Outcomes in Severe Sepsis Free
- April 17, 2013
- Neil M. Ampel, MD
- Infectious Diseases
In a double-blind, randomized, phase II study, 28-day mortality among prior statin users was significantly lower with continued atorvastatin therapy than with placebo.- Reviewing:
- Kruger P et al., Am J Respir Crit Care Med 2013 Apr; 187:743. O'Kane CM et al., Am J Respir Crit Care Med 2013 Apr; 187:672.
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High-Potency Statins Associated with Acute Kidney Injury Free
- April 11, 2013
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Risk is greatest during the first 4 months of treatment.- Reviewing:
- Dormuth CR et al., BMJ 2013 Mar 19; 346:f880.
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Do Statins Protect Against Hepatocellular Carcinoma?
- February 15, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Possibly, but a high number needed to treat recommends against their use as chemopreventive agents.- Reviewing:
- Singh S et al., Gastroenterology 2013 Feb; 144:323.
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Statins and the Risk for Death from Pneumonia
- November 21, 2012
- Neil M. Ampel, MD
- Infectious Diseases
Two retrospective studies suggested that risk was reduced in statin users, but a large, controlled trial is needed to confirm this effect.- Reviewing:
- Chopra V et al., Am J Med 2012 Nov; 125:1111. Mortensen EM et al., Clin Infect Dis 2012 Dec 1; 55:1466.
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Statins as Anticancer Drugs? Free
- November 8, 2012
- Allan S. Brett, MD
- General Medicine
In an observational study with limitations, statin use by cancer patients was associated with lower 3-year mortality.
CME Exam- Reviewing:
- Nielsen SF et al., N Engl J Med 2012 Nov 8; 367:1792. Caporaso NE., N Engl J Med 2012 Nov 8; 367:1848.
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NSAIDs and Statins Might Have Chemopreventive Potential for Barrett Esophagus Free
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
In an observational study, use of the two drugs together greatly reduced the risk for neoplastic progression.- Reviewing:
- Kastelein F et al., Gastroenterology 2011 Dec; 141:2000.
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Statins Don't Lower Risk for Infections
- December 27, 2011
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
A meta-analysis of 11 randomized trials showed no benefit.- Reviewing:
- van den Hoek HL et al., BMJ 2011 Nov 29; 343:d7281.
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Statins May Prevent Blocked Veins as Well as Blocked Arteries
- September 14, 2011
- Joel M. Gore, MD
- Cardiology
Atherosclerosis patients who received statins or antiplatelets had a lower incidence of VTE than those who did not, and the statin effect appeared to be dose-related.- Reviewing:
- Khemasuwan D et al., Am J Med 2011 Sep; 124:852.
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Succinylcholine Is Safe for Patients on Statins Free
- July 1, 2011
- Cheryl Lynn Horton, MD, and Ron M. Walls, MD, FRCPC, FAAEM
- Emergency Medicine
No clinically significant differences in postoperative muscle pain or serum indicators of muscle injury were noted between statin users and nonusers.- Reviewing:
- Turan A et al., Anesthesiology 2011 Jul; 115:28.
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Which Statins Are Best for Treating HIV-Related Dyslipidemia?
- January 14, 2011
- Keith Henry, MD
- HIV/AIDS
In an observational study, atorvastatin and rosuvastatin were more effective than pravastatin, with similar toxicity rates.- Reviewing:
- Singh S et al., Clin Infect Dis 2011 Feb 1; 52:387.
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Statins and Primary Prevention for Patients at High Risk for Heart Disease
- July 15, 2010
- Thomas L. Schwenk, MD
- General Medicine
The benefit, if any, is very small.
CME Exam- Reviewing:
- Ray KK et al., Arch Intern Med 2010 Jun 28; 170:1024. de Lorgeril M et al., Arch Intern Med 2010 Jun 28; 170:1032. Kaul S et al., Arch Intern Med 2010 Jun 28; 170:1073. Green LA., Arch Intern Med 2010 Jun 28; 170:1007.
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Immune-Mediated Necrotizing Myopathy Associated with Statins
- May 18, 2010
- Andrea Swenson, MD
- Neurology
Unlike toxic myopathies, this condition persists despite statin discontinuation but responds to immunosuppressive therapy.- Reviewing:
- Grable-Esposito P et al., Muscle Nerve 2010 Feb; 41:185.
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Cardiovascular Benefits of Statins vs. Risk for Incident Diabetes Free
- March 4, 2010
- Bruce Soloway, MD
- General Medicine
One additional case of incident diabetes occurred for every 255 patients who received statins for 4 years.- Reviewing:
- Sattar N et al., Lancet 2010 Feb 27; 375:735.
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High-Dose Statins Before Percutaneous Coronary Intervention
- January 13, 2010
- Howard C. Herrmann, MD
- Cardiology
In statin-naive patients, a single loading dose of atorvastatin within 24 hours before PCI significantly reduced the rate of periprocedural MI.- Reviewing:
- Briguori C et al., J Am Coll Cardiol 2009 Dec 1; 54:2157. Tsimikas S., J Am Coll Cardiol 2009 Dec 1; 54:2164.
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Effect of Statins on Responses to Interferon Beta-1a
- October 6, 2009
- Hillel Panitch, MD
- Neurology
A retrospective study suggests that statins do not interfere with the therapeutic effects of IFNβ-1a in multiple sclerosis, but methodologic problems render the issue unresolved.- Reviewing:
- Rudick RA et al., Neurology 2009 Jun 9; 72:1989.
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Statins for Primary Prevention: Homing in on Effectiveness
- August 5, 2009
- Harlan M. Krumholz, MD, SM
- Cardiology
A new meta-analysis bolsters the case for benefit.- Reviewing:
- Brugts JJ et al., BMJ 2009 Jun 30; 338:b2376.
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Statins for Primary Prevention of Cardiovascular Disease Free
- July 16, 2009
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Statin users were less likely to experience major adverse coronary or cerebrovascular events.
Audio Interview- Reviewing:
- Brugts JJ et al., BMJ 2009 Jun 30; 338:b2376.
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Statins and Venous Thrombosis
- April 14, 2009
- David Green, MD, PhD
- Oncology and Hematology
Recent studies confirm that statins lower risk for VT and suggest that the agents could aid in managing venous disease.- Reviewing:
- Ramcharan AS et al., J Thromb Haemost 2009 Apr; 7:514. Sørensen HT et al., J Thromb Haemost 2009 Apr; 7:521. Cushman M., J Thromb Haemost 2009 Apr; 7:511.
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Do Statins Prevent Cardiovascular Events in Hemodialysis Patients?
- March 30, 2009
- Harlan M. Krumholz, MD, SM
- Cardiology
Not according to findings from this randomized, controlled trial- Reviewing:
- Fellström BC et al., N Engl J Med 2009 Apr 2; 360:1395. Strippoli GFM and Craig JC., N Engl J Med 2009 Apr 2; 360:1455.
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Statins and Risk for Alzheimer Disease
- March 17, 2009
- Gad A. Marshall, MD
- Neurology
In a large, prospective study, use of statin cholesterol-lowering drugs was associated with reduced risk for Alzheimer disease, independent of the drug’s lipophilicity.- Reviewing:
- Haag MDM et al., J Neurol Neurosurg Psychiatry 2009 Jan; 80:13. Sparks L., J Neurol Neurosurg Psychiatry 2009 Jan; 80:1.
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