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Search for rheumatoid arthritis in all Journal Watch editions
Physician-authored summaries on the latest research on rheumatoid arthritis, editorials on rheumatoid arthritis, and perspectives on rheumatoid arthritis - drawn from the top medical journals.
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You searched for: rheumatoid arthritis
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TNF Inhibitors Are Associated with Higher Risk for Melanoma in Rheumatoid Arthritis Patients
- April 25, 2013
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Absolute risk was small, but relative risk was increased by 50% in patients treated with tumor necrosis factor inhibitors.- Reviewing:
- Raaschou P et al., BMJ 2013 Apr 8; 346:f1939.
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Can We Reduce or Withdraw Etanercept in Patients with Rheumatoid Arthritis?
- March 12, 2013
- Jonathan S. Coblyn, MD
- General Medicine
Patients might do well on a lower etanercept dose after low disease activity is achieved for 36 weeks.- Reviewing:
- Smolen JS et al., Lancet 2013 Jan 17;: Miossec P., Lancet 2013 Jan 17;:
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A New Oral Drug for Rheumatoid Arthritis
- March 12, 2013
- Jonathan S. Coblyn, MD
- General Medicine
Adding tofacitinib to methotrexate after anti–tumor necrosis factor agents failed was effective in more than 40% of patients.- Reviewing:
- Burmester GR et al., Lancet 2013 Feb 9; 381:451. Miossec P., Lancet 2013 Feb 9; 381:429.
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Elevated Rheumatoid Factor Is Associated with Excess Risk for Developing RA
- September 27, 2012
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
In people without clinical rheumatoid arthritis, levels >25 IU/mL were associated with high future risk.
CME Exam- Reviewing:
- Nielsen SF et al., BMJ 2012 Sep 6; 345:e5244. Simard JF and Holmqvist M., BMJ 2012 Sep 6; 345:e5841.
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New Oral Drug Therapy for Rheumatoid Arthritis
- September 18, 2012
- Jonathan S. Coblyn, MD
- General Medicine
Two studies show that tofacitinib might be as effective as biologic therapies.- Reviewing:
- Fleischmann R et al., N Engl J Med 2012 Aug 9; 367:495. van Vollenhoven RF et al., N Engl J Med 2012 Aug 9; 367:508. Fox DA., N Engl J Med 2012 Aug 9; 367:565.
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Moderate Alcohol Consumption Is Associated with Lower Risk for Rheumatoid Arthritis Free
- July 26, 2012
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
In a prospective study, risk was 40% to 50% lower in older women who weren't teetotalers.- Reviewing:
- Di Giuseppe D et al., BMJ 2012 Jul 10; 345:e4230.
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Rheumatoid Arthritis Linked to Risks for Atrial Fibrillation and Stroke Free
- March 22, 2012
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Close monitoring of RA patients is warranted.- Reviewing:
- Lindhardsen J et al., BMJ 2012 Mar 8; 344:e1257.
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Should Prednisone Be Added to Methotrexate for Early Rheumatoid Arthritis?
- March 22, 2012
- Jamaluddin Moloo, MD, MPH
- General Medicine
Yes, according to a randomized trial — but with caveats.- Reviewing:
- Bakker MF et al., Ann Intern Med 2012 Mar 6; 156:329.
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TNF Inhibitors Double Infection Risk Free
- July 28, 2011
- Allan S. Brett, MD
- General Medicine
At 1 year, tumor necrosis factor inhibitors were associated with excess risk for serious infections in rheumatoid arthritis patients.
CME Exam- Reviewing:
- Komano Y et al., J Rheumatol 2011 Jul; 38:1258.
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Patients Taking Disease-Modifying Antirheumatic Drugs Also Developed Less New Diabetes
- July 15, 2011
- Jeffrey P. Callen, MD
- Dermatology
Decreased incidence was associated with TNF antagonists and hydroxychloroquine but not with methotrexate.
CME Exam- Reviewing:
- Solomon DH et al., JAMA 2011 Jun 22/29; 305:2525. Bongartz T and Kudva Y., JAMA 2011 Jun 22/29; 305:2573.
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New Classification Criteria for Rheumatoid Arthritis
- September 23, 2010
- Allan S. Brett, MD
- General Medicine
The goal is early identification of patients who can benefit from intervention.
CME Exam- Reviewing:
- Aletaha D et al., Arthritis Rheum 2010 Sep; 62:2569.
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Drug-Induced Dermatomyositis Due to Tumor Necrosis Factor Antagonists
- August 27, 2010
- Jeffrey P. Callen, MD
- Dermatology
TNF inhibitors are valuable against inflammatory disease, but reports link their use to dermatomyositis in some patients.- Reviewing:
- Klein R et al., Arch Dermatol 2010 Jul; 146:780. Brunasso AMG et al., J Rheumatol 2010 Jul; 37:1549.
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Is the Incidence and Prevalence of Rheumatoid Arthritis Rising Among Women?
- August 17, 2010
- Jonathan S. Coblyn, MD
- General Medicine
Smoking, vitamin D deficiency, and low-estrogen-dose oral contraceptives could be factors.
CME Exam- Reviewing:
- Myasoedova E et al., Arthritis Rheum 2010 Jun; 62:1576.
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Global Gastrointestinal Events with Celecoxib vs. Diclofenac and Omeprazole
Risks for clinical events throughout the GI tract were lower with a cyclooxygenase-2 inhibitor than with a nonselective nonsteroidal anti-inflammatory drug plus a proton-pump inhibitor.- Reviewing:
- Chan FKL et al., Lancet 2010 Jun 17;: Rahme E and Bernatsky S., Lancet 2010 Jun 17;:
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Infliximab Is Superior to Conventional DMARDs in Patients with Early RA
- August 13, 2009
- Bruce Soloway, MD
- General Medicine
Adding a TNF antagonist to methotrexate resulted in a significantly better response to therapy.- Reviewing:
- van Vollenhoven RF et al., Lancet 2009 Aug 8; 374:459.
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Herpes Zoster in Arthritis Patients Who Take Anti-TNF-α Agents
- March 10, 2009
- Thomas L. Schwenk, MD
- General Medicine
- Reviewing:
- Strangfeld A et al., JAMA 2009 Feb 18; 301:737. Whitley RJ and Gnann JW Jr., JAMA 2009 Feb 18; 301:774.
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Herpes Zoster and TNF-α Antagonists Free
- March 4, 2009
- Richard T. Ellison III, MD
- Infectious Diseases
Rheumatoid arthritis patients treated with infliximab or adalimumab are at increased risk for herpes zoster.- Reviewing:
- Strangfeld A et al., JAMA 2009 Feb 18; 301:737. Whitley RJ and Gnann JW Jr., JAMA 2009 Feb 18; 301:774.
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Risk for Herpes Zoster with Anti–TNF-α Agents
- February 27, 2009
- Jan V. Hirschmann, MD
- Dermatology
Herpes zoster may occur more often and more severely in patients receiving monoclonal antibody treatment.- Reviewing:
- Strangfeld A et al., JAMA 2009 Feb 18; 301:737.
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TNF Antagonists for Treatment of Juvenile Rheumatoid Arthritis
- September 25, 2008
- Deborah M. DeMarco, MD
- General Medicine
In children, adalimumab with or without methotrexate reduced disease activity and number of flares.- Reviewing:
- Lovell DJ et al., N Engl J Med 2008 Aug 21; 359:810.
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Methotrexate plus Etanercept for Early, Moderate-to-Severe RA
- August 12, 2008
- Thomas L. Schwenk, MD
- General Medicine
Likelihood of remission and of radiographic nonprogression was greater with combination therapy than with methotrexate alone.- Reviewing:
- Emery P et al., Lancet 2008 Aug 2; 372:375. Kremer JM., Lancet 2008 Aug 2; 372:347.
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