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Search for proton-pump inhibitor (PPI) in all Journal Watch editions
Physician-authored summaries on the latest research on proton-pump inhibitor (PPI), editorials on proton-pump inhibitor (PPI), and perspectives on proton-pump inhibitor (PPI) - drawn from the top medical journals.
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You searched for: proton-pump inhibitor (PPI)
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Rabeprazole-Based Rescue Therapy for Helicobacter pylori Successful in Malaysia
After PPI-based triple therapy failed, most infections were eradicated with rabeprazole and amoxicillin.- Reviewing:
- Goh K-L et al., Aliment Pharmacol Ther 2012 May; 35:1097.
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Combined Ibuprofen/Famotidine Tablet Might Reduce Ulcers
Patients receiving the combination tablet developed fewer upper gastrointestinal ulcers than those receiving ibuprofen alone.- Reviewing:
- Laine L et al., Am J Gastroenterol 2012 Mar; 107:379.
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Proton-Pump Inhibitor Use Associated with Spontaneous Bacterial Peritonitis
- April 20, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
A higher rate of recent PPI use was seen in patients with cirrhosis who had SBP versus those who did not.
CME Exam- Reviewing:
- Goel GA et al., Clin Gastroenterol Hepatol 2012 Apr; 10:422.
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Low-Dose or High-Dose PPI Therapy After Endoscopic Hemostasis?
A small study conducted in Taiwan suggests that after successful endoscopic hemostasis in patients with bleeding peptic ulcers, low- and high-dose pantoprazole are equally effective.- Reviewing:
- Chen C-C et al., Aliment Pharmacol Ther 2012 Apr; 35:894.
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Preventing Upper Gastrointestinal Bleeding in Patients with Acute Coronary Syndrome
A proton-pump inhibitor was superior to an H2-receptor antagonist.
CME Exam- Reviewing:
- Ng F-H et al., Am J Gastroenterol 2012 Mar; 107:389.
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Represcribing High-Risk Drugs After Acute Upper Gastrointestinal Bleeding
Within 1 year after a bleeding episode, many patients were again receiving the potentially causative drug — but often with a proton-pump inhibitor.- Reviewing:
- Dall M et al., Aliment Pharmacol Ther 2012 Feb 7;:
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PPI Use Associated with Hip-Fracture Risk in Postmenopausal Women Free
Data from a large, prospective cohort study showed risk to be highest in smokers and in women with lengthy PPI use.
CME Exam- Reviewing:
- Khalili H et al., BMJ 2012 Jan 31; 344:e372.
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Sequential Therapy Bests Triple Therapy for H. pylori Infection
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Eradication rates were higher; adverse events were similar.- Reviewing:
- Kim YS et al., Aliment Pharmacol Ther 2011 Nov; 34:1098.
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Diagnosing Gastroenterological Causes of Noncardiac Chest Pain Free
- December 22, 2011
- David A. Johnson, MD
- Gastroenterology
Endoscopy and pH tests should be used to confirm GERD status to guide decisions on treatment with PPIs and the need for further diagnostic testing.
CME Exam- Reviewing:
- Kahrilas PJ et al., Gut 2011 Nov; 60:1473.
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NSAID Use Can Decrease Hemoglobin Level Free
Data summarized from two separate randomized trials showed drops of ≥2 g/dL in hemoglobin in celecoxib and diclofenac users.
CME Exam- Reviewing:
- Goldstein JL et al., Aliment Pharmacol Ther 2011 Oct; 34:808.
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Ulcers Heal While Patients Continue Aspirin Therapy
Efficacy of rabeprazole in treating ulcers was high with either aspirin or clopidogrel.
CME Exam- Reviewing:
- Luo J-C et al., Aliment Pharmacol Ther 2011 Sep; 34:519.
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PPI Cotherapy Is Cost-Effective in Patients Taking Aspirin
Cotherapy with a proton-pump inhibitor and aspirin produced better gastrointestinal and cardiovascular outcomes than aspirin alone and was cost-effective in all age groups.
CME Exam- Reviewing:
- Saini SD et al., Aliment Pharmacol Ther 2011 Jul; 34:243.
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New Asia-Specific Guidelines for Nonvariceal Upper Gastrointestinal Bleeding
Recommendations take into account varying healthcare resources and the epidemiology of gastrointestinal disease in Asian and Pacific countries.- Reviewing:
- Sung JJY et al., Gut 2011 Jul 1;:
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Long-Term Proton-Pump Inhibitor Therapy in Children Free
A high percentage of children developed low-grade enterochromaffin cell-like hyperplasia.- Reviewing:
- Hassall E et al., Aliment Pharmacol Ther 2011 Apr; 33:829.
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Management of Unstable Angina/Non–ST-Elevation Myocardial Infarction: Focused Update of ACC/AHA Guidelines Free
- April 20, 2011
- Howard C. Herrmann, MD
- Cardiology
New recommendations pertain mainly to platelet inhibition.- Reviewing:
- Wright RS et al., J Am Coll Cardiol 2011 Mar 28;:
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Another Study of PPIs plus Clopidogrel
- March 22, 2011
- Allan S. Brett, MD
- General Medicine
The proton-pump inhibitor esomeprazole prevented recurrent ulcers in clopidogrel-treated patients.- Reviewing:
- Hsu P-I et al., Gastroenterology 2011 Mar; 140:791.
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Predicting Response to Proton-Pump Inhibitors for Dyspepsia
- February 11, 2011
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
The value of a therapeutic index to predict response is unclear.- Reviewing:
- Meineche-Schmidt V et al., Aliment Pharmacol Ther 2011 Jan; 33:41.
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Selective Serotonin Reuptake Inhibitors and Peptic Ulcers
People with uncomplicated ulcers were 50% more likely to be using SSRIs, suggesting a possible direct ulcerogenic effect.
CME Exam- Reviewing:
- Dall M et al., Aliment Pharmacol Ther 2010 Dec; 32:1383.
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Proton-Pump Inhibitor Therapy for Postnasal Drainage?
- November 19, 2010
- David A. Johnson, MD
- Gastroenterology
Lansoprazole outperformed placebo, reviving old questions about silent gastroesophageal reflux disease and extraesophageal reflux.- Reviewing:
- Vaezi MF et al., Gastroenterology 2010 Aug 27;:
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Data on Clopidogrel and Omeprazole Offer 'Reassurance' on Cardiovascular Risk, Researchers Say Free
- October 7, 2010
- Physician's First Watch
Patients on dual antiplatelet therapy showed no increase in cardiovascular events while receiving omeprazole to lower risks for gastrointestinal bleeding, according to a New England...
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