- Home>
- Journal Watch
- >
- proton-pump inhibitor (PPI)
Search for proton-pump inhibitor (PPI) in all Journal Watch editions
Physician-authored summaries on the latest research on proton-pump inhibitor (PPI), editorials on proton-pump inhibitor (PPI), and perspectives on proton-pump inhibitor (PPI) - drawn from the top medical journals.
Sort by:
Items 1 to 20 of 129 results - Relevance
- Date
You searched for: proton-pump inhibitor (PPI)
-
Bleeding Ulcers in Helicobacter pylori–Infected Aspirin Users
- March 28, 2013
- Allan S. Brett, MD
- General Medicine
After H. pylori eradication, recurrent ulcer bleeding is uncommon, despite ongoing aspirin use.- Reviewing:
- Chan FKL et al., Gastroenterology 2013 Mar; 144:528.
-
A Magnetic Sphincter Device Shows Promise for GERD
- February 20, 2013
- David A. Johnson, MD
- Gastroenterology
Esophageal acid exposure was significantly reduced in 64% of patients who had the device surgically implanted.
CME Exam- Reviewing:
- Ganz RA et al., N Engl J Med 2013 Feb 21; 368:719.
-
Citalopram Reduces GERD Symptoms in Hypersensitive Esophagus
- January 18, 2013
- David A. Johnson, MD
- Gastroenterology
This selective serotonin reuptake inhibitor showed promise in a small clinical trial of patients who did not respond to acid suppressants.
CME Exam- Reviewing:
- Viazis N et al., Am J Gastroenterol 2012 Nov; 107:1662.
-
Endoscopy for Gastroesophageal Reflux Disease — Best Practice Advice
- January 3, 2013
- Jamaluddin Moloo, MD, MPH
- General Medicine
The American College of Physicians has published new guidelines.- Reviewing:
- Shaheen NJ et al., Ann Intern Med 2012 Dec 4; 157:808.
-
Acid Suppression and Effectiveness of Ampicillin for Helicobacter Pylori Free
- November 9, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
At a low pH, H. pylori bacteria stopped dividing, making ampicillin ineffective. More sustained acid suppression might be useful for refractory infections.- Reviewing:
- Marcus EA et al., Aliment Pharmacol Ther 2012 Nov; 36:972.
-
Aspirin and PPIs Might Prevent Cancer in Barrett Esophagus
- October 5, 2012
- David A. Johnson, MD
- Gastroenterology
In the largest randomized U.S. trial to date, a combination regimen reduced levels of a biomarker for increased production of the COX-2 enzyme, which is implicated in carcinogenesis.
CME Exam- Reviewing:
- Falk GW et al., Gastroenterology 2012 Oct; 143:917.
-
Proton-Pump Inhibitors Increase Serious Infection Rates in Decompensated Cirrhosis
- October 5, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
However, H2 receptor antagonists did not increase risk for infections and offer a reasonable alternative.
CME Exam- Reviewing:
- Bajaj JS et al., Aliment Pharmacol Ther 2012 Sep 11;:
-
Does Clopidogrel Increase Mucosal Damage when Added to Aspirin Therapy?
Apparently not. Endoscopic evaluation after 1 week showed similar damage with aspirin alone, clopidogrel alone, or the two combined in a small, randomized crossover study.- Reviewing:
- Uotani T et al., Clin Gastroenterol Hepatol 2012 Aug; 10:879.
-
Second-Look Endoscopy after Endoscopic Hemostasis Needed for Few
Routine second-look endoscopy reduced the risk for recurrence of nonvariceal upper gastrointestinal bleeding in selected patients with high-risk stigmata.- Reviewing:
- Ouali SE et al., Gastrointest Endosc 2012 Aug; 76:283.
-
Must We Stop Prophylactic Aspirin in Patients Who Develop Peptic Ulcers?
- July 26, 2012
- Allan S. Brett, MD
- General Medicine
Proton-pump inhibitors usually heal aspirin-associated ulcers, even if aspirin is continued.- Reviewing:
- Liu C-P et al., Am J Gastroenterol 2012 Jul; 107:1022.
-
Discussion on CardioExchange: Does PPI + DAPT = MI? Free
- July 18, 2012
- The Editors
- Cardiology
Sign in or register today for access to this and other blogs and discussions. -
Debunking the Notion That Proton-Pump Inhibitors Cause Bacterial Overgrowth
- July 6, 2012
- David A. Johnson, MD
- Gastroenterology
A large, retrospective study using glucose hydrogen breath testing found no association.
CME Exam- Reviewing:
- Ratuapli SK et al., Am J Gastroenterol 2012 May; 107:730.
-
High-Dose PPI, Amoxicillin, and Metronidazole for Primary Treatment of H. pylori Infection?
In a multicenter study conducted in Spain, this regimen had a high cure rate and was well tolerated.- Reviewing:
- Sánchez-Delgado J et al., Aliment Pharmacol Ther 2012 Jul; 36:190.
-
Rabeprazole-Based Rescue Therapy for Helicobacter pylori Successful in Malaysia
After PPI-based triple therapy failed, most infections were eradicated with rabeprazole and amoxicillin.- Reviewing:
- Goh K-L et al., Aliment Pharmacol Ther 2012 May; 35:1097.
-
Combined Ibuprofen/Famotidine Tablet Might Reduce Ulcers
Patients receiving the combination tablet developed fewer upper gastrointestinal ulcers than those receiving ibuprofen alone.- Reviewing:
- Laine L et al., Am J Gastroenterol 2012 Mar; 107:379.
-
Proton-Pump Inhibitor Use Associated with Spontaneous Bacterial Peritonitis
- April 20, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
A higher rate of recent PPI use was seen in patients with cirrhosis who had SBP versus those who did not.
CME Exam- Reviewing:
- Goel GA et al., Clin Gastroenterol Hepatol 2012 Apr; 10:422.
-
Low-Dose or High-Dose PPI Therapy After Endoscopic Hemostasis?
A small study conducted in Taiwan suggests that after successful endoscopic hemostasis in patients with bleeding peptic ulcers, low- and high-dose pantoprazole are equally effective.- Reviewing:
- Chen C-C et al., Aliment Pharmacol Ther 2012 Apr; 35:894.
-
Preventing Upper Gastrointestinal Bleeding in Patients with Acute Coronary Syndrome
A proton-pump inhibitor was superior to an H2-receptor antagonist.
CME Exam- Reviewing:
- Ng F-H et al., Am J Gastroenterol 2012 Mar; 107:389.
-
Represcribing High-Risk Drugs After Acute Upper Gastrointestinal Bleeding
Within 1 year after a bleeding episode, many patients were again receiving the potentially causative drug — but often with a proton-pump inhibitor.- Reviewing:
- Dall M et al., Aliment Pharmacol Ther 2012 Feb 7;:
-
PPI Use Associated with Hip-Fracture Risk in Postmenopausal Women Free
Data from a large, prospective cohort study showed risk to be highest in smokers and in women with lengthy PPI use.
CME Exam- Reviewing:
- Khalili H et al., BMJ 2012 Jan 31; 344:e372.
Sort by:
Items 1 to 20 of 129 results - Relevance
- Date
