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Search for osteoarthritis in all Journal Watch editions
Physician-authored summaries on the latest research on osteoarthritis, editorials on osteoarthritis, and perspectives on osteoarthritis - drawn from the top medical journals.
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You searched for: osteoarthritis
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Pathogenesis of Osteoarthritis
- July 6, 2010
- Anthony L. Komaroff, MD
- General Medicine
We might have a new therapeutic target.- Reviewing:
- Saito T et al., Nat Med 2010 Jun; 16:678. Yang S et al., Nat Med 2010 Jun; 16:687. Husa M et al., Nat Med 2010 Jun; 16:641.
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Topical Voltaren Gel for Hand Osteoarthritis
- October 6, 2009
- Allan S. Brett, MD
- General Medicine
Diclofenac gel was better than placebo for relieving pain.- Reviewing:
- Altman RD et al., J Rheumatol 2009 Sep; 36:1991.
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Physiotherapy After Total Knee Arthroplasty for Osteoarthritis
- November 29, 2007
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Physiotherapy provides added benefits in the short term but not in the long term.- Reviewing:
- Minns Lowe CJ et al., BMJ 2007 Oct 20; 335:812.
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Chondroitin for Osteoarthritis Pain: Not Effective
The authors of a meta-analysis believe that use of chondroitin should be discouraged in routine practice.- Reviewing:
- Reichenbach S et al., Ann Intern Med 2007 Apr 17; 146:580-90. Felson DT., Ann Intern Med 2007 Apr 17; 146:611-2.
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Self-Management of Osteoarthritis Helps, but Only a Bit
- December 5, 2006
- Keith I. Marton, MD
- General Medicine
Anxiety scores declined, but pain and disability were unaffected.- Reviewing:
- Buszewicz M et al., BMJ 2006 Oct 28; 333:879-82. Croft P and Hay E., BMJ 2006 Oct 28; 333:867-8.
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Is Acupuncture Effective for Knee Osteoarthritis?
- August 1, 2006
- Richard Saitz, MD, MPH, FACP, FASAM
- General Medicine
Both traditional and sham needling led to less pain and better function.- Reviewing:
- Scharf HP et al., Ann Intern Med 2006 Jul 4; 145:12-20.
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Transdermal Fentanyl for Severe Osteoarthritis Free
- July 4, 2006
- Allan S. Brett, MD
- General Medicine
This opioid is a treatment option for patients with severe knee or hip osteoarthritis, but side effects are common.- Reviewing:
- Langford R et al., Arthritis Rheum 2006 Jun; 54:1829-37.
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Liver Injury Associated with 'Medical Food' Treatment for Osteoarthritis Free
- June 19, 2012
- Physician's First Watch
Flavocoxid, a medical food marketed as Limbrel, has been associated with reversible hepatotoxicity in patients with osteoarthritis, according to an Annals of Internal Medicine study... -
Adult Stem Cell Therapy Treats Osteoarthritis in Mice
- June 12, 2012
- Anthony L. Komaroff, MD
- General Medicine
Kartogenin promotes formation of new cartilage.- Reviewing:
- Johnson K et al., Science 2012 May 11; 336:717.
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Glucosamine and Chondroitin Are of No Help in Osteoarthritis, Researchers Find Free
- September 17, 2010
- Physician's First Watch
Glucosamine and chondroitin, either alone or in combination, have no clinically relevant effect on joint pain in osteoarthritis, according to a BMJ meta-analysis.The... -
Does Exercise Protect Against Development of Knee Osteoarthritis?
- September 25, 2007
- Robert W. Rebar, MD
- General Medicine
Medial tibial cartilage volumes were significantly larger in women who exercised.- Reviewing:
- Hanna F et al., Menopause 2007 Sep/Oct; 14:830.
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Chondroitin Doesn't Reduce Pain in Osteoarthritis Free
- April 17, 2007
- Physician's First Watch
Chondroitin does not appear to reduce joint pain in people with osteoarthritis and its use should be discouraged, concludes a study in the Annals of... -
Self-Management Helps Patients Handle Osteoarthritis Symptoms but Doesn't Reduce Physical Pain Free
- October 13, 2006
- Physician's First Watch
Osteoarthritis patients who learned self-management techniques had less anxiety and felt better about managing their symptoms, even though they experienced no less pain than... -
Acupuncture Beats Conservative Therapy for Osteoarthritis Pain Free
- July 5, 2006
- Physician's First Watch
Both acupuncture and sham acupuncture were more effective than conservative therapy for relieving chronic osteoarthritic knee pain, according to a study in yesterday’s Annals of... -
Gastroprotection with a New COX-2 Inhibitor: Clinically Significant?
- February 21, 2007
- Bruce Soloway, MD
- General Medicine
In a secondary analysis of results from earlier trials, etoricoxib had little clinical GI benefit over diclofenac.- Reviewing:
- Laine L et al., Lancet 2007 Feb 10; 369:465-73. Drenth JPH and Verheugt FW., Lancet 2007 Feb 10; 369:439-40.
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A New COX-2 Inhibitor Is No More Cardiotoxic Than an Older NSAID
- November 28, 2006
- Bruce Soloway, MD
- General Medicine
Etoricoxib had similar rates of thrombotic cardiovascular events as diclofenac, but caused more hypertension and edema.- Reviewing:
- Cannon CP et al., Lancet 2006 Nov 18; 368:1771-81. García Rodríguez LA and Patrignani P., Lancet 2006 Nov 18; 368:1745-7.
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CV Risk with Etoricoxib vs. Diclofenac
- November 22, 2006
- Beat J. Meyer, MD
- Cardiology
Cardiovascular outcomes with the traditional NSAID diclofenac and the still-unapproved selective COX-2 inhibitor etoricoxib were compared by researchers who pooled results from three non–placebo-controlled randomized trials.- Reviewing:
- Cannon CP et al. for the MEDAL Steering Committee., Lancet 2006 Nov 18; 368:1771-81. García Rodríguez LA and Patrignani P., Lancet 2006 Nov 18; 368:1745-7.
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Gastrointestinal Tolerability of Nonselective NSAIDs and Valdecoxib
Nonsteroidal anti-inflammatory drug (NSAID) use is associated more often with moderate gastrointestinal symptoms than with the well-established severe complications of bleeding and symptomatic gastroduodenal ulcers. . . .- Reviewing:
- Eisen GM et al., Aliment Pharmacol Ther 2005 Mar 1; 21:591-8.
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Molecule Implicated in Osteoarthritic Cartilage Deterioration
- April 26, 2005
- Anthony L. Komaroff, MD
- General Medicine
Osteoarthritis develops from repeated wear-and-tear damage that triggers degradation of cartilaginous surfaces in joints. The extracellular matrix of cartilage is composed primarily of two molecules: . . .- Reviewing:
- Glasson SS et al., Nature 2005 Mar 31; 434:644-8. Stanton H et al., Nature 2005 Mar 31; 434:648-52.
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Gastrointestinal Complications from NSAID Use in Clinical Practice Free
In a PROBE trial of 8067 patients with osteoarthritis, 1.3% using celecoxib experienced GI complications compared with 2.4% using a nonselective NSAID.- Reviewing:
- Cryer B et al., Am J Gastroenterol 2013 Mar; 108:392.
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