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Search for metabolism in all Journal Watch editions
Physician-authored summaries on the latest research on metabolism, editorials on metabolism, and perspectives on metabolism - drawn from the top medical journals.
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You searched for: metabolism
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Behavioral and Circadian Rhythms: Best to Be in Synch
- April 6, 2009
- Jonathan Silver, MD
- Psychiatry
Misaligned cycles lead to adverse cardiometabolic consequences in this laboratory study.- Reviewing:
- Scheer FAJL et al., Proc Natl Acad Sci U S A 2009 Mar 17; 106:4453. Ramsey KM and Bass J., Proc Natl Acad Sci U S A 2009 Mar 17; 106:4069.
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Metabolic Benefits of Calorie Restriction
- April 11, 2006
- Thomas L. Schwenk, MD
- General Medicine
Dramatic calorie restriction in rats prolongs life; the same could be true for humans.- Reviewing:
- Heilbronn LK et al., JAMA 2006 Apr 5; 295:1539-48.
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Clarifying Cortisol Metabolism in Critically Ill Patients: Complicated and Somewhat Less Confusing
- April 11, 2013
- Patricia Kritek, MD
- General Medicine
Critically ill patients had increased production and decreased clearance of cortisol.- Reviewing:
- Boonen E et al., N Engl J Med 2013 Mar 19;:
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Do Cell Phones Affect Brain Glucose Metabolism?
- March 22, 2011
- Adam Gazzaley, MD, PhD
- Neurology
An imaging study reveals an association, but the clinical significance remains undetermined.- Reviewing:
- Volkow ND et al., JAMA 2011 Feb 23; 305:808.
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Liver Disease and Drug Metabolism
- October 30, 2006
- Steven Dubovsky, MD
- Psychiatry
Clinicians need to vary medication doses with the severity of liver disease and with how the drug is metabolized.- Reviewing:
- Frye RF et al., Clin Pharmacol Ther 2006 Sep; 80:235-45.
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PIs and Insulin Metabolism
- December 14, 2009
- Keith Henry, MD
- HIV/AIDS
In a study of HIV-negative volunteers, a 4-week course of lopinavir/ritonavir worsened lipid levels but had no effect on insulin or glucose levels.- Reviewing:
- Pao VY et al., AIDS 2009 Nov 3;:
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An Immunoassay for Hepcidin, the Master Regulator of Iron Metabolism
- December 9, 2008
- David Green, MD, PhD
- Oncology and Hematology
Researchers validated the first enzyme-linked immunosorbent assay to measure hepcidin in serum and urine.- Reviewing:
- Ganz T et al., Blood 2008 Nov 15; 112:4292.
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Escitalopram, Metabolism, and Cytochrome P450 Genotype
- April 7, 2008
- Steven Dubovsky, MD
- Psychiatry
Patients' response to escitalopram or associated adverse effects may be due to genotype.- Reviewing:
- Rudberg I et al., Clin Pharmacol Ther 2008 Feb; 83:322.
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Abnormal Glucose Metabolism and Mortality Free
- June 27, 2007
- Joel M. Gore, MD
- Cardiology
In a population-based, Australian study, even mild forms of hyperglycemia were associated with increased risk.- Reviewing:
- Barr ELM et al., Circulation 2007 Jun 18;:
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Imaging Amyloid and Regional Cerebral Glucose Metabolism in Alzheimer Disease Free
- June 19, 2007
- Stephen Gomperts, MD, PhD
- Neurology
Amyloid imaging distinguishes AD from normal brain, but its clinical utility awaits further study.- Reviewing:
- Edison P et al., Neurology 2007 Feb 13; 68:501-8.
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Effects of Thiazide Diuretics on Glucose Metabolism
- May 23, 2012
- Joel M. Gore, MD
- Cardiology
Two crossover studies confirm adverse effects of thiazide diuretics — but not of potassium-sparing diuretics or beta-blockers — on short-term glucose tolerance.- Reviewing:
- Stears AJ et al., Hypertension 2012 May; 59:934. Elliott WJ., Hypertension 2012 May; 59:911.
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Gene for Vitamin D Metabolism Implicated in Multiple Sclerosis Free
- January 17, 2012
- Robert T. Naismith, MD
- Neurology
Mutations that lead to altered vitamin D activation are identified as rare variants in familial MS.- Reviewing:
- Ramagopalan SV et al., Ann Neurol 2011 Dec; 70:881.
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Dietary Sugars and Lipid Metabolism
- May 4, 2010
- Thomas L. Schwenk, MD
- General Medicine
Added sugar intake is associated with some markers of dyslipidemia.- Reviewing:
- Welsh JA et al., JAMA 2010 Apr 21; 303:1490.
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Disturbances of Glucose Metabolism in Depression
- April 7, 2008
- Joel Yager, MD
- Psychiatry
Whole-body glucose disposal is impaired in depressed patients.- Reviewing:
- Schweiger U et al., Psychosom Med 2008 Feb/Mar; 70:170.
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More Doubts About Tight Glycemic Control in the ICU
- December 24, 2008
- Allan S. Brett, MD
- General Medicine
ICU mortality was not lessened by low blood glucose targets, and some evidence suggests that brain metabolism in brain-injured patients might be affected adversely by low glucose targets.- Reviewing:
- Arabi YM., Crit Care Med 2008 Dec; 36:3190. Oddo M et al., Crit Care Med 2008 Dec; 36:3233.
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Pathogenesis of Hemochromatosis
- June 18, 2007
- David Green, MD, PhD
- Oncology and Hematology
Normal iron metabolism occurs in duodenal enterocytes even when the Hfe protein is absent.- Reviewing:
- Spasic MV et al., Blood 2007 May 15; 109:4511-7.
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Intestinal Metabolism Leads to Variable Bioavailability of Drugs
- January 24, 2002
- Steven Dubovsky, MD
- Psychiatry
The bioavailability of oral medication has significant interindividual differences; it has been assumed that these differences are primarily due to first-pass (presystemic) metabolism in the . . .- Reviewing:
- von Richter O et al., Clin Pharmacol Ther 2001 Sep; 70:217-27.
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Inborn Errors of Metabolism and Adult-Onset Neurologic Disease
- September 20, 2000
- EH Kolodny
- Neurology
Inborn errors of metabolism are often overlooked as a cause of neurologic disease in adults. Pediatric forms of these disorders are generally relatively severe and . . .- Reviewing:
- Gray RGF et al., J Neurol Neurosurg Psychiatry 2000 Jul; 69:
5 12 .
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First-Pass Drug Metabolism Is Not Limited to the Liver
- October 1, 1996
- S Dubovsky
- Psychiatry
First-pass or pre-systemic drug metabolism, which contributes to inter-individual variability of serum levels after oral administration, is traditionally attributed to cytochrome P450 (CYP) isoenzymes in . . .- Reviewing:
- Paine MF et al., Clin Pharmacol Ther 1996 Jul; 60:
14 24 .
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METRONIDAZOLE FOR DISORDERS OF INTERMEDIARY METABOLISM.
- June 7, 1988
- HGA
- General Medicine
Dietary management is the conventional way to treat disorders of intermediary metabolism; however, restricting proteins in afflicted children can be difficult. Bain and colleagues report . . .- Reviewing:
- Bain M D; Jones M; Borriello S P; Tracey B M et al., Lancet 1988 May 14; 1:
1078 1079 .
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