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Search for liver failure in all Journal Watch editions
Physician-authored summaries on the latest research on liver failure, editorials on liver failure, and perspectives on liver failure - drawn from the top medical journals.
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You searched for: liver failure
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Simple Index Predicts Outcomes in Acute Liver Failure
- December 14, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
A new index outperformed standard prognostic tools but requires new capacity to perform an assay to measure M-30 antigen.- Reviewing:
- Rutherford A et al., Gastroenterology 2012 Nov; 143:1237.
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Drug-Induced Acute Liver Failure
- January 25, 2011
- Allan S. Brett, MD
- General Medicine
In 133 cases encountered during a decade, spontaneous recovery was uncommon.
CME Exam- Reviewing:
- Reuben A et al., Hepatology 2010 Dec; 52:2065.
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N-Acetylcysteine for Nonacetaminophen Acute Liver Failure?
- October 9, 2009
- Atif Zaman, MD, MPH
- Gastroenterology
NAC improved transplant-free survival in patients at coma grades I–II.- Reviewing:
- Lee WM et al., Gastroenterology 2009 Sep; 137:856.
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Rapid Diagnosis of Acute Liver Failure Due to Wilson Disease
- December 5, 2008
- Atif Zaman, MD, MPH
- Gastroenterology
The best biomarker for Wilson disease is all of them.- Reviewing:
- Korman JD et al., Hepatology 2008 Oct; 48:1167.
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Identifying Acetaminophen-Induced Acute Liver Failure
- June 13, 2006
- Atif Zaman, MD, MPH
- Gastroenterology
Measurement of acetaminophen–protein adducts might aid in the diagnosis of acetaminophen-induced acute liver failure.- Reviewing:
- Davern TJ II et al., Gastroenterology 2006 Mar; 130:687-94.
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Acetaminophen-Induced Acute Liver Failure in the U.S.
- January 3, 2006
- Atif Zaman, MD, MPH
- Gastroenterology
Acetaminophen-induced hepatotoxicity accounts for most acute liver failure cases in the U.S.- Reviewing:
- Larson AM et al., Hepatology 2005 Dec; 42:1364-72.
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Hypertonic Saline Reduces Intracranial Pressure in Acute Liver Failure
- April 14, 2004
- Kenneth D. Flora, MD
- Gastroenterology
Patients with acute liver failure are at risk for developing cerebral edema and intracranial hypertension (IH). IH is thought to be caused by water influx . . .- Reviewing:
- Murphy N et al., Hepatology 2004 Feb; 39:464-70.
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Serious Non-AIDS Events in HIV-Infected Patients
- September 27, 2010
- Keith Henry, MD
- HIV/AIDS
Such events are common in the modern HIV-treatment era and are associated with increased mortality.- Reviewing:
- Mocroft A et al., J Acquir Immune Defic Syndr 2010 Oct 1; 55:262.
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Transjugular Intrahepatic Portosystemic Shunts for Refractory Hepatohydrothorax
- May 7, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Symptomatic relief was achieved by most patients, but overall survival was poor.- Reviewing:
- Dhanasekaran R et al., Am J Gastroenterol 2010 Mar; 105:635.
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Idiosyncratic DILI: Does a Dose-Response Relation Exist? Free
- September 12, 2008
- Atif Zaman, MD, MPH
- Gastroenterology
Researchers examined commonly prescribed medications at three dosing levels to look for dose-related drug-induced liver injury.- Reviewing:
- Lammert C et al., Hepatology 2008 Jun; 47:2003.
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Variability of INR and Its Effect on MELD Scores
- September 21, 2007
- Atif Zaman, MD, MPH
- Gastroenterology
Whether standard INR measurements are reliable and reproducible in patients with liver disease has been questioned.- Reviewing:
- Tripodi A et al., Hepatology 2007 Aug; 46:520. Bellest L et al., Hepatology 2007 Aug; 46:528.
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Falling AIDS Mortality and Rising Rates of Liver Failure in Hemophilia Patients
- May 31, 2006
- Abigail Zuger, MD
- HIV/AIDS
As patients live longer, hepatitis C virus begins to take a toll on this heavily coinfected population.- Reviewing:
- del Amo J et al., J Acquir Immune Defic Syndr 2006 Apr 15; 41:624-31.
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FDA Alert: Pemoline Market Withdrawal
- December 9, 2005
- Martin T. Stein, MD
- Pediatrics and Adolescent Medicine
Pemoline (Cylert and generic pemoline products) is a central nervous system stimulant currently prescribed for treatment of patients with ADHD. For many years, pediatricians have . . . -
Anticoagulants Can Prevent — Not Just Treat — Portal Vein Thrombosis in Cirrhosis
- November 30, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
Enoxaparin was safe and effective in preventing PVT, improving survival, and reducing hepatic decompensation in patients with advanced cirrhosis.- Reviewing:
- Villa E et al., Gastroenterology 2012 Nov; 143:1253.
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Coffee and Hepatitis C Virus Infection
- January 8, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Greater coffee consumption was associated with lower risk for liver disease progression.- Reviewing:
- Freedman ND et al., Hepatology 2009 Nov; 50:1360.
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Etravirine Can Cause Severe Skin and Hypersensitivity Reactions
- August 31, 2009
- Paul E. Sax, MD
- HIV/AIDS
Severe skin or hypersensitivity reactions should prompt immediate cessation of the drug. -
Predicting Hepatic Decompensation in Cirrhotic Patients
- October 5, 2007
- Atif Zaman, MD, MPH
- Gastroenterology
Patients with hepatic venous pressure gradient measurements of <10 mm Hg were at low risk for developing decompensation within 4 years.- Reviewing:
- Ripoll C et al., Gastroenterology 2007 Aug; 133:481.
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Obesity-Related Cryptogenic Cirrhosis Linked with Shortened Survival
- July 16, 2002
- Kenneth D. Flora, MD
- Gastroenterology
Nonalcoholic steatohepatitis (NASH) is a chronic form of liver disease that is associated with obesity and often is accompanied by diabetes mellitus and hyperlipidemia. Although . . .- Reviewing:
- Ratziu V et al., Hepatology 2002 Jun; 35:1485-93.
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Arterial Lactate Levels Predict Mortality from Paracetamol Overdose
- March 12, 2002
- Kenneth D. Flora, MD
- Gastroenterology
Acute liver failure due to paracetamol (acetaminophen) ingestion remains a frequent problem. King's College Hospital selection criteria often are applied to determine which patients require . . .- Reviewing:
- Bernal W et al., Lancet 2002 Feb 16; 359:558-63.
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Two Novel Approaches to Preventing Cirrhosis
- March 17, 2000
- AL Komaroff
- General Medicine
Each year, over 40,000 Americans die of liver failure; only about 4,000 liver transplants are available. Ongoing liver injury leads to a vigorous, but dysfunctional, . . .- Reviewing:
- Rudolph KL et al., Science 2000 Feb 18; 287:
1253 1258 . Kobayashi N et al., Science 2000 Feb 18; 287:1258 1262 .
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