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Search for hepatitis C in all Journal Watch editions
Physician-authored summaries on the latest research on hepatitis C, editorials on hepatitis C, and perspectives on hepatitis C - drawn from the top medical journals.
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You searched for: hepatitis C
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Time to Broaden HCV Testing?
- May 8, 2012
- Abigail Zuger, MD
- General Medicine
Improvements in treatment are changing the calculus of screening the general population for hepatitis C virus infection.- Reviewing:
- Coffin PO et al., Clin Infect Dis 2012 May 1; 54:1259.
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High Hepatitis B Surface Antigen Level Increases Risk for Hepatocellular Carcinoma
- May 4, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
The finding was for patients with a low hepatitis B virus DNA level.- Reviewing:
- Tseng T-C et al., Gastroenterology 2012 May; 142:1140.
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New Tests Predict Clinical Outcomes in Chronic Hepatitis C Virus Free
- May 4, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
A battery of quantitative liver-function tests might provide a noninvasive method of risk assessment.- Reviewing:
- Everson GT et al., Hepatology 2012 Apr; 55:1019.
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Exploring Immunity to Hepatitis C
Researchers have identified an anti–hepatitis C monoclonal antibody that is broadly cross-reactive and is protective in a mouse model.- Reviewing:
- Giang E et al., Proc Natl Acad Sci U S A 2012 Apr 17; 109:6205.
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HCV Genotype Might Affect Response in Interferon-Free Regimens
- April 20, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
In a small exploratory analysis, patients with IL28B genotype CC trended towards greater reductions in viral load than those with genotypes TT or CT.
CME Exam- Reviewing:
- Chu TW et al., Gastroenterology 2012 Apr; 142:790.
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Response to Interferon-Based Therapy in HBV Varies by IL28B Polymorphisms
- March 30, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
More evidence that host factors matter in the pursuit of successful antiviral therapy- Reviewing:
- Sonneveld MJ et al., Gastroenterology 2012 Mar; 142:513.
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Mortality from Hepatitis C Virus Infection Is Rising in the U.S.
- March 15, 2012
- Jamaluddin Moloo, MD, MPH
- General Medicine
Age-adjusted mortality for HCV infection surpassed that for HIV infection as of 2007.- Reviewing:
- Ly KN et al., Ann Intern Med 2012 Feb 21; 156:271.
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Mortality Rate Now Higher for HCV Than HIV Infection in the U.S.
- March 9, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
As many as 75% of people with HCV infection do not know that they are infected; a one-time screening holds promise for identifying and treating them.- Reviewing:
- Ly KN et al., Ann Intern Med 2012 Feb 21; 156:271. Rein DB et al., Ann Intern Med 2012 Feb 21; 156:263.
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α-Fetoprotein Screening in Patients with Hepatitis C
- February 7, 2012
- Allan S. Brett, MD
- General Medicine
Positive predictive value for hepatocellular cancer was low; AFP screening is not recommended.- Reviewing:
- Sterling RK et al., Am J Gastroenterol 2012 Jan; 107:64.
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Transmission of Blood-Borne Pathogens in Injection-Drug Users
- January 30, 2012
- Rajesh T. Gandhi, MD
- HIV/AIDS
Hepatitis B virus and HIV are coming under control because of harm-reduction programs, but hepatitis C virus continues to be a problem.- Reviewing:
- Blomé MA et al., J Viral Hepat 2011 Dec; 18:831.
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Acute Kidney Injury Predicts Mortality in Acute Alcoholic Hepatitis
- January 27, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
New criteria for renal failure are superior to traditional criteria in predicting 90-day mortality and should be put to use in clinical settings.- Reviewing:
- Altamirano J et al., Clin Gastroenterol Hepatol 2012 Jan; 10:65.
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Highlights from the Conference on Chronic Viral Hepatitis Infection Free
- January 27, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
Medical models that improve screening and effectiveness of treatment in the community setting are required to reduce the disease burden.- Reviewing:
- Ward JW et al., Hepatology 2012 Jan; 55:307.
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New Antivirals Show Promise for an Interferon-Free Hepatitis C Treatment
- January 18, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
Patients with HCV genotype 1 and previous null response achieved a 36% sustained virologic response at 24 weeks of therapy with daclatasvir and asunaprevir alone.- Reviewing:
- Lok AS et al., N Engl J Med 2012 Jan 19; 366:216. Chung RT., N Engl J Med 2012 Jan 19; 366:273.
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Transplant-Associated HCV Transmission
- January 11, 2012
- Stephen G. Baum, MD
- Infectious Diseases
Stricter guidelines or more-careful adherence to current ones might have prevented hepatitis C virus transmission to kidney and cardiopulmonary-patch recipients.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Dec 23; 60:1697.
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Liver Fibrosis Progression After Acute HCV Infection in HIV-Positive Patients
- December 22, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
The rate of fibrosis progression is initially rapid but subsequently seems to slow down.- Reviewing:
- Vogel M et al., Clin Infect Dis 2011 Dec 7;:
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Drug-Induced Liver Injury — Or Hepatitis E Virus Infection?
- December 9, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Acute HEV infection is a small but important cause of liver injury that is suspected to be drug induced.- Reviewing:
- Davern TJ et al., Gastroenterology 2011 Nov; 141:1665.
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Entecavir Protects Against Recurrent HBV Infection After Liver Transplantation
- December 9, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
No episodes of hepatitis B virus flares or graft loss caused by recurrent infection were observed.
CME Exam- Reviewing:
- Fung J et al., Gastroenterology 2011 Oct; 141:1212.
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Histologic Features Can Differentiate Drug-Induced Liver Injury from Autoimmune Hepatitis
- December 2, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Investigators report progress in using histologic data to more accurately distinguish between the two conditions.
CME Exam- Reviewing:
- Suzuki A et al., Hepatology 2011 Sep; 54:931.
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Emerging Treatment Options for Severe Acute Alcoholic Hepatitis
- November 10, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Adding N-acetylcysteine to glucocorticoid therapy did not improve 6-month survival. Early liver transplant did, but in a selectively chosen subgroup.
CME Exam- Reviewing:
- Nguyen-Khac E et al., N Engl J Med 2011 Nov 10; 365:1781. Mathurin P et al., N Engl J Med 2011 Nov 10; 365:1790. Brown RS Jr., N Engl J Med 2011 Nov 10; 365:1836.
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Adherence to HCV Therapy Is Associated with Virologic Response
- October 21, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Patients with better adherence to peginterferon and ribavirin showed better early and sustained virologic responses to HCV infection.- Reviewing:
- Lo Re V III et al., Ann Intern Med 2011 Sep 20; 155:353.
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