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Search for hepatitis B in all Journal Watch editions
Physician-authored summaries on the latest research on hepatitis B, editorials on hepatitis B, and perspectives on hepatitis B - drawn from the top medical journals.
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You searched for: hepatitis B
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Predictors of Poor Outcomes in Autoimmune Hepatitis
- May 17, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Liver-related death or need for liver transplantation was associated with age at presentation, incomplete treatment response, and low albumin, but not advanced fibrosis.- Reviewing:
- Ngu JH et al., Hepatology 2013 May 1;:
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Incident HCV Infection in MSM
- May 13, 2013
- Carlos del Rio, MD
- HIV/AIDS
Hepatitis C virus infection has occurred among men who have sex with men since the beginning of the HIV epidemic, with higher rates of infection among those who are HIV-infected.- Reviewing:
- Witt MD et al., Clin Infect Dis 2013 Apr 22;:
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A Global View of HCV Infection and Barriers to Treatment
- May 10, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Even with new treatments on the horizon for HCV infection, worldwide issues of access, cost, and gaps in physician knowledge must be addressed.- Reviewing:
- Mohd Hanafiah K et al., Hepatology 2013 Apr; 57:1333. McGowan CE at al., Hepatology 2013 Apr; 57:1325.
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Sofosbuvir-Based Therapy for HCV Infection: The Results Are In
- April 23, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
The evidence shows superior efficacy and tolerability of sofosbuvir-based regimens versus those currently available, particularly in patients with HCV genotype 1.- Reviewing:
- Lawitz E et al., N Engl J Med 2013 Apr 23;:
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HCV Testing in HIV-Infected MSM: Once Is Not Enough
- April 22, 2013
- Rajesh T. Gandhi, MD
- HIV/AIDS
A high incidence of HCV seroconversion in this population implies that repeat HCV testing should be routinely performed, particularly in individuals with high-risk sexual behaviors.- Reviewing:
- Garg S et al., Clin Infect Dis 2013 Mar 26;:
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Does HBV Suppression with Entecavir Affect Clinical Outcomes? Free
- April 19, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Evidence from an ongoing prospective cohort study indicates yes, but only in patients with cirrhosis, and only when virologic response is strong.- Reviewing:
- Zoutendijk R et al., Gut 2013 May; 62:760.
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Sofosbuvir plus Peginterferon and Ribavirin for Chronic HCV Infection Free
- April 12, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
In phase II trials, a 12-week regimen resulted in high virologic response 24 weeks after treatment, no sofosbuvir-specific adverse effects, and no virologic breakthrough.- Reviewing:
- Lawitz E et al., Lancet Infect Dis 2013 Mar 15;: Kowdley KV et al., Lancet 2013 Mar 15;:
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Where Are We with Pentoxifylline for Severe Alcoholic Hepatitis?
- April 12, 2013
- Atif Zaman, MD,
- Gastroenterology
A pooled analysis of available trial data showed a 53% reduction in mortality from hepatorenal syndrome, but no reduction in overall mortality, compared with placebo.- Reviewing:
- Parker R et al., Aliment Pharmacol Ther 2013 May; 37:845.
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Targeting Host Cell MicroRNA: An Exciting New Approach to HCV Treatment
- April 3, 2013
- Rajesh T. Gandhi, MD
- Infectious Diseases
A drug that sequesters a liver-cell microRNA decreases HCV RNA — in some cases, to undetectable levels.- Reviewing:
- Janssen HLA et al., N Engl J Med 2013 Mar 27;: Lieberman J and Sarnow P., N Engl J Med 2013 Mar 27;:
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Liver-Related Deaths Uncommon in HIV-Infected Patients Without Hepatitis Virus Coinfection
- March 25, 2013
- Rajesh T. Gandhi, MD
- HIV/AIDS
Findings from a large cohort study suggest that such patients rarely die from antiretroviral hepatotoxicity.- Reviewing:
- Kovari H et al., Clin Infect Dis 2013 Mar 15; 56:870.
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Successful Treatment of HCV Infection Prevents Hepatocellular Carcinoma Free
- March 22, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Achieving sustained virologic response conferred a 76% reduced risk for developing hepatocellular carcinoma.
CME Exam- Reviewing:
- Morgan RL et al., Ann Intern Med 2013 Mar 5; 158:329.
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Host Genome Plays a Part in Spontaneous Resolution of Hepatitis C Virus Infection
- March 21, 2013
- Jamaluddin Moloo, MD, MPH
- General Medicine
Certain alleles on two chromosomes were associated with a greater likelihood of resolution.- Reviewing:
- Duggal P et al., Ann Intern Med 2013 Feb 19; 158:235.
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Hepatitis C Virus Seldom Is Transmitted Sexually
- March 19, 2013
- Abigail Zuger, MD
- General Medicine
This study should reassure monogamous heterosexual couples who are discordant for the virus.- Reviewing:
- Terrault NA et al., Hepatology 2013 Mar; 57:881.
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Do Futility Rules for HCV Triple Therapy Work?
- March 8, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Apparently, yes. In a retrospective analysis, the rules had high validity for identifying patients unlikely to achieve SVR.- Reviewing:
- Adda N et al., Clin Gastroenterol Hepatol 2013 Feb; 11:193.
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Hepatitis Flares and Mortality in Patients with HIV and Hepatitis Virus Coinfection
- March 4, 2013
- Rajesh T. Gandhi, MD
- HIV/AIDS
Pretreatment inflammation and coagulation biomarkers are associated with increased risk for these important complications after initiation of antiretroviral therapy.- Reviewing:
- Andrade BB et al., J Infect Dis 2013 Feb 13;:
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No Known Strategies Prevent Vertical HCV Transmission
- February 8, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
A systematic review of perinatal management strategies came up empty.- Reviewing:
- Cottrell EB et al., Ann Intern Med 2013 Jan 15; 158:109.
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Rapid Development of Decompensated Cirrhosis in HIV-Infected Men with Primary HCV Infection
- February 4, 2013
- Emily J. Cartwright, MD, and Carlos del Rio, MD
- HIV/AIDS
Men who acquire hepatitis C virus infection when immunocompromised from HIV may experience an accelerated HCV disease course, with rapid development of cirrhosis and end-stage liver disease.- Reviewing:
- Fierer DS et al., Clin Infect Dis 2013 Jan 16;:
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All-Oral Interferon-Free Treatment for Patients with Hepatitis C
- January 29, 2013
- Allan S. Brett, MD
- General Medicine
Responses were impressive in some subgroups.- Reviewing:
- Gane EJ et al., N Engl J Med 2013 Jan 3; 368:34. Poordad F et al., N Engl J Med 2013 Jan 3; 368:45.
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Successful Clearance of Hepatitis C Virus Is Associated with Lower All-Cause Mortality Free
- January 11, 2013
- Atif Zaman, MD, MPH
- Gastroenterology
Further justification for use of HCV therapies to achieve sustained virologic response- Reviewing:
- van der Meer AJ et al., JAMA 2012 Dec 26; 308:2584.
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HBV Treatment Reverses Cirrhosis Free
- January 9, 2013
- Rajesh T. Gandhi, MD
- Infectious Diseases
Nearly three quarters of hepatitis B virus–infected patients with cirrhosis at baseline were no longer cirrhotic after 5 years of tenofovir therapy.- Reviewing:
- Marcellin P et al., Lancet 2012 Dec 10;:
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