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Search for breast tumors in all Journal Watch editions
Physician-authored summaries on the latest research on breast tumors, editorials on breast tumors, and perspectives on breast tumors - drawn from the top medical journals.
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You searched for: breast tumors
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Goserelin Does Not Preserve Ovarian Function During Chemotherapy
- July 26, 2011
- William J. Gradishar, MD
- Oncology and Hematology
This luteinizing-hormone–releasing hormone agonist was of no benefit for young women receiving anthracycline-based adjuvant chemotherapy for breast cancer.- Reviewing:
- Gerber B et al., J Clin Oncol 2011 Jun 10; 29:2334.
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ASCO 2010 Report: Breast Cancer Free
- July 13, 2010
- William J. Gradishar, MD
- Oncology and Hematology
Key trials focused on surgical approaches, eribulin, and bevacizumab plus chemotherapy. -
Postmastectomy Radiation Therapy for Early-Stage Breast Cancer
- June 22, 2010
- William J. Gradishar, MD
- Oncology and Hematology
Given low locoregional recurrence rates among many patients who do not undergo this treatment, recommendations for its use should be reconsidered.- Reviewing:
- Sharma R et al., Ann Surg Oncol 2010 May 5;:
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In Breast Cancer, Not All Small Tumors Are Equal
- January 5, 2010
- William J. Gradishar, MD
- Oncology and Hematology
Tumors =1 cm that are positive for HER2 more commonly recur than HER2-negative tumors.- Reviewing:
- Curigliano G et al., J Clin Oncol 2009 Dec 1; 27:5693. Gonzalez-Angulo AM et al., J Clin Oncol 2009 Dec 1; 27:5700.
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Can Anthracycline Response Be Predicted from HER2 and TOP2A Status of Breast Tumors?
- October 6, 2009
- William J. Gradishar, MD
- Oncology and Hematology
The predictive value of these genetic markers remains unclear.- Reviewing:
- Tubbs R et al., J Clin Oncol 2009 Aug 20; 27:3881. Pritchard KI., J Clin Oncol 2009 Aug 20; 27:3875.
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Screening Detects Many Breast Cancers, but How Many Are Overdiagnosed?
- August 6, 2009
- Wendy S. Biggs, MD
- Women's Health
Population-wide mammography screening is associated with higher incidence of breast cancer, but the estimated overdiagnosis rate is more than 50%.- Reviewing:
- Jørgensen KJ and Gøtzsche PC., BMJ 2009 Jul 9; 339:b2587. Welch HG., BMJ 2009 Jul 9; 339:b1425.
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Are Anthracyclines Justified for Breast Cancer?
- June 2, 2009
- William J. Gradishar, MD
- Oncology and Hematology
Most patients are not likely to benefit from anthracycline-based adjuvant chemotherapy.- Reviewing:
- O’Malley FP et al., J Natl Cancer Inst 2009 May 6; 101:644. Slamon DJ and Press MF., J Natl Cancer Inst 2009 May 6; 101:615.
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Factors Associated with Triple-Negative Breast Cancer Remain Elusive in Black Women
- April 30, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Likelihood of poor-prognosis tumors in black women was not explained by BMI.- Reviewing:
- Stead LA et al., Breast Cancer Res 2009 Mar 25; 11:R18.
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The Effect of Food on Lapatinib Bioavailability
- April 7, 2009
- William J. Gradishar, MD
- Oncology and Hematology
When administered with food, lapatinib bioavailability was substantially higher than when given to fasted patients.- Reviewing:
- Koch KM et al., J Clin Oncol 2009 Mar 10; 27:1191.
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Second Breast Cancers: Early Detection Remains Important
- April 2, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Retrospective analysis underscores the value of close clinical and mammographic follow-up of breast cancer survivors.- Reviewing:
- Houssami N et al., Ann Oncol 2009 Mar 17;:
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Even Small HER2-Positive Tumors May Require Aggressive Treatment Free
- December 15, 2008
- Physician's First Watch
Patients may ask about a widely reported study suggesting that even some very small breast tumors may require aggressive treatment after surgery. The findings were... -
Mechanism of ER-Negative Breast Cancer in BRCA1-Mutation Carriers Free
- December 11, 2007
- William J. Gradishar, MD
- Oncology and Hematology
BRCA1 protein directly regulates the estrogen-receptor α gene by binding to its promoter.- Reviewing:
- Hosey AM et al., J Natl Cancer Inst 2007 Nov 13;: Jordan VC., J Natl Cancer Inst 2007 Nov 13;:
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Gene Signatures Predict Response to Cancer Therapy
- December 4, 2007
- William J. Gradishar, MD
- Oncology and Hematology
Identifying patients who will not respond to standard chemotherapy would permit direct entry into investigational regimens.- Reviewing:
- Bonnefoi H et al., Lancet Oncol 2007 Nov 14;:
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CHF in Older Women After Adjuvant Anthracycline-Based Chemotherapy for Breast Cancer Free
- October 30, 2007
- William J. Gradishar, MD
- Oncology and Hematology
Adjuvant therapy that includes anthracyclines raises risk for adverse cardiac events.- Reviewing:
- Pinder MC et al., J Clin Oncol 2007 Sep 1; 25:3808.
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Breast Tumors in Black Women More Likely to Be Estrogen-Receptor Negative Free
- September 7, 2007
- Physician's First Watch
Breast cancer is more likely to be estrogen-receptor negative in black women than in white women, according to findings that will be presented this... -
Preoperative Trastuzumab, Docetaxel, and Carboplatin for HER2-Positive Breast Cancer
- June 18, 2007
- William J. Gradishar, MD
- Oncology and Hematology
Preoperative trastuzumab benefits some patients with HER2-positive tumors and increases the number of patients who can undergo breast-conserving surgery.- Reviewing:
- Coudert BP et al., J Clin Oncol 2007 May 21;: Buzdar AU et al., Clin Cancer Res 2007 Jan 1; 13:228-33.
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Plasma Prolactin Levels Influence Breast Cancer Development
- April 13, 2007
- William J. Gradishar, MD
- Oncology and Hematology
Prolactin probably plays a role in the etiology of breast cancer, particularly ER+ breast cancer, among both premenopausal and postmenopausal women.- Reviewing:
- Tworoger SS et al., J Clin Oncol 2007 Mar 19;:
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Food for Thought: The Red Meat–Breast Cancer Link
- January 11, 2007
- Diane E. Judge, APN/CNP
- Women's Health
Nurses’ Health Study II data suggest that red meat consumption increases the risk for premenopausal hormone receptor–positive breast cancer.- Reviewing:
- Cho E et al., Arch Intern Med 2006 Nov 13; 166:2253-9.
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Mammography Explains Some, but Not All, Breast Cancer Disparities
Black women were more likely than white women to have advanced breast tumors, and all minority groups had lower rates of adequate mammographic screening.- Reviewing:
- Smith-Bindman R et al., Ann Intern Med 2006 Apr 18; 144:541-53.
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Breast Cancer in Blacks: Less Common, More Deadly
- May 3, 2005
- Andrew M. Kaunitz, MD
- Women's Health
Among Women's Health Initiative participants, black women with breast cancer were more likely than white women to have poor-prognosis tumors.- Reviewing:
- Chlebowski RT et al., J Natl Cancer Inst 2005 Mar 16; 97:439-48.
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