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Search for bone research in all Journal Watch editions
Physician-authored summaries on the latest research on bone research, editorials on bone research, and perspectives on bone research - drawn from the top medical journals.
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You searched for: bone research
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DMPA and Bone Health: Settling a Fractious Issue Free
- March 14, 2013
- Eleanor Bimla Schwarz, MD, MS
- Women's Health
Large retrospective cohort study shows DMPA use did not raise fracture risk.- Reviewing:
- Lanza LL et al., Obstet Gynecol 2013 Mar; 121:593.
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Primary Sclerosing Cholangitis and Bone Disease
- February 25, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Age, body-mass index, and duration of inflammatory bowel disease were risk factors for osteoporosis in patients with PSC.
CME Exam- Reviewing:
- Angulo P et al., Gastroenterology 2011 Jan; 140:180.
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Bone Marrow Transplantation: Hope for Recessive Dystrophic Epidermolysis Bullosa? Free
- August 11, 2010
- Mary Wu Chang, MD
- Dermatology
Results in a small group represent progress toward sustained clinical improvement.- Reviewing:
- Wagner JE et al., N Engl J Med 2010 Aug 12; 363:629. Bruckner-Tuderman L., N Engl J Med 2010 Aug 12; 363:680.
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Rosiglitazone May Reduce Bone Density
- April 24, 2007
- Allan S. Brett, MD
- General Medicine
Bone density at the hip decreased by 2% in postmenopausal women taking rosiglitazone.- Reviewing:
- Grey A et al., J Clin Endocrinol Metab 2007 Apr; 92:1305-10.
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Bone Marrow Cell Transfer After STEMI: Mixed Results
- October 25, 2006
- Harlan M. Krumholz, MD, SM
- Cardiology
Contradictory findings from two trials remind us that this area of clinical research is still in its early stages.- Reviewing:
- Schächinger V et al. for the REPAIR-AMI Investigators., N Engl J Med 2006 Sep 21; 355:1210-21. Lunde K et al., N Engl J Med 2006 Sep 21; 355:1199-209. Rosenzweig A., N Engl J Med 2006 Sep 21; 355:1274-7.
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No Long-Term Benefit of Post-MI Bone Marrow Cell Transfer
- May 11, 2006
- Howard C. Herrmann, MD
- Cardiology
A promising benefit at 6 months had diminished by 18 months.- Reviewing:
- Meyer GP et al., Circulation 2006 Mar 14; 113:1287-94. Welt FG and Losordo DW., Circulation 2006 Mar 14; 113:1272-4.
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A Molecule Protects and Restores Bone Density in Mice
- June 7, 2012
- Anthony L. Komaroff, MD
- General Medicine
Could this discovery lead to better osteoporosis therapy in humans?- Reviewing:
- Hayashi M et al., Nature 2012 May 3; 485:69. Zaidi M and Iqbal J., Nature 2012 May 3; 485:47.
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Occult Metastases in Breast Cancer Do Not Affect Survival Substantially
- August 16, 2011
- Abigail S. Caudle, MD, and Henry Mark Kuerer, MD, PhD, FACS
- Oncology and Hematology
Routine detection of occult sentinel node and bone marrow micrometastases is not clinically indicated for early breast cancer.- Reviewing:
- Giuliano AE et al., JAMA 2011 Jul 27; 306:385. Merkow RP and Ko CY., JAMA 2011 Jul 27; 306:436.
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Proton-Pump Inhibitor Dosing and Negative Consequences
- June 8, 2010
- Jamaluddin Moloo, MD, MPH
- General Medicine
Four studies about the effects of PPI therapy- Reviewing:
- Wang C-H et al., Arch Intern Med 2010 May 10; 170:751. Gray SL et al., Arch Intern Med 2010 May 10; 170:765. Linsky A et al., Arch Intern Med 2010 May 10; 170:772. Howell MD et al., Arch Intern Med 2010 May 10; 170:784. Katz MH., Arch Intern Med 2010 May 10; 170:747.
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Zoledronic Acid During GnRH Therapy for Prostate Cancer
- April 9, 2007
- Robert Dreicer, MD, MS, FACP
- Oncology and Hematology
Annual intravenous therapy increased BMD and reduced bone turnover in men with nonmetastatic disease.- Reviewing:
- Michaelson MD et al., J Clin Oncol 2007 Mar 20; 25:1038-42.
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Quelling Brain Tumor–Initiating Cells Free
- December 6, 2006
- Manuel Hidalgo, MD, PhD
- Oncology and Hematology
Receptor stimulation might have therapeutic value in fighting one of the most lethal forms of brain cancer.- Reviewing:
- Piccirillo SGM et al., Nature 2006 Dec 7; 444:761-5.
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Progestogen-Only Contraception: Unlimited Use Remains Appropriate
- July 13, 2006
- Robert W. Rebar, MD
- General Medicine
Bone-mineral density was lower in progestogen users than in nonusers, but the clinical significance of this finding isn’t clear.- Reviewing:
- Curtis KM and Martins SL., Contraception 2006 May; 73:470-87. d’Arcangues C., Contraception 2006 May; 73:443-4.
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Is Long-Term Bisphosphonate Therapy Safe?
- April 5, 2005
- Allan S. Brett, MD
- General Medicine
In a case series, long-term alendronate use was associated with reduced rates of bone formation and inadequate fracture healing.
Audio Interview- Reviewing:
- Odvina CV et al., J Clin Endocrinol Metab 2005 Mar; 90:1294-301. Ott SM., J Clin Endocrinol Metab 2005 Mar; 90:1897-9.
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Bone Marrow Edema Is a Risk Factor for OA Progression
- September 19, 2003
- Richard Saitz, MD, MPH, FACP, FASAM
- General Medicine
How can we identify osteoarthritis (OA) patients who are at high risk for disease progression? Bone marrow edema (detected by magnetic resonance imaging of the . . .- Reviewing:
- Felson DT et al., Ann Intern Med 2003 Sep 2; 139:330-6.
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Estren Reverses Bone Loss in Mice
- November 15, 2002
- Anthony L. Komaroff, MD
- General Medicine
Biologists and physicians have assumed that both beneficial and adverse effects of estrogens (and androgens) are triggered by their attachment to nuclear receptors. Within the . . .- Reviewing:
- Kousteni S et al., Science 2002 Oct 25; 298:843-6.
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AEDs and Bone Disease: What Neurologists Do in Practice
- April 26, 2002
- Martha J. Morrell, MD
- Neurology
Suppressing seizures remains a primary goal of antiepilepsy drug (AED) therapy, but maintaining general health is emerging as an equally pressing concern. New information about . . .- Reviewing:
- Valmadrid C et al., Arch Neurol 2001 Sep; 58:1369-74. Heller HJ and Sakhaee K., Arch Neurol 2001 Sep; 58:1352-3.
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Bone Markers of Limited Value in Monitoring Osteoporosis Treatment
- February 6, 2001
- DE Judge
- Women's Health
Postmenopausal estrogen therapy (ET) increases skeletal mass by opposing bone resorption. Serial BMD measurements reliably demonstrate the therapeutic efficacy of ET; however, significant BMD improvement . . .- Reviewing:
- Watts NB et al., Menopause 2000 Nov/Dec; 7:
375 382 .
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Discovery of a Critical Immune Mediator of Joint Destruction and Bone Loss
- December 3, 1999
- AL Komaroff
- General Medicine
The joint destruction seen in rheumatoid arthritis (RA) is known to be immunologically mediated, but which molecules are critical to the process has been unclear. . . .- Reviewing:
- Kong Y-Y et al., Nature 1999 Nov 18; 402:
304 309 .
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Does Previous Invasive Aspergillosis Rule Out Bone Marrow Transplantation?
- June 1, 1998
- B Britigan
- Infectious Diseases
Invasive aspergillosis is a well-recognized complication of intensive chemotherapy for hematologic malignancies. Successful treatment requires antifungal therapy and resolution of the patient's neutropenia. Once in . . .- Reviewing:
- Offner F et al., Clin Infect Dis 1998 May; 26:
1098 1103 .
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Mixed Results from Intracoronary Infusions of Adult Stem Cells in CAD
- September 28, 2006
- Anthony L. Komaroff, MD
- General Medicine
Two of three new studies found a small benefit in left ventricular ejection fraction; none of the studies found important complications.- Reviewing:
- Schächinger V et al., N Engl J Med 2006 Sep 21; 355:1210-21. Lunde K et al., N Engl J Med 2006 Sep 21; 355:1199-209. Assmus B et al., N Engl J Med 2006 Sep 21; 355:1222-32. Schwartz RS., N Engl J Med 2006 Sep 21; 355:1189-91. Rosenzweig A., N Engl J Med 2006 Sep 21; 355:1274-7.
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