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Search for bisphosphonates in all Journal Watch editions
Physician-authored summaries on the latest research on bisphosphonates, editorials on bisphosphonates, and perspectives on bisphosphonates - drawn from the top medical journals.
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You searched for: bisphosphonates
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Can Bisphosphonates Prevent Breast Cancer?
- July 15, 2010
- Andrew M. Kaunitz, MD
- Women's Health
Observational studies support the potential for chemoprophylaxis.
CME Exam- Reviewing:
- Rennert G et al., J Clin Oncol 2010 Jun 21;: Chlebowski RT et al., J Clin Oncol 2010 Jun 21;: Gnant M., J Clin Oncol 2010 Jun 21;:
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Do Bisphosphonates Cause Atypical Femoral Fractures?
- April 27, 2010
- Allan S. Brett, MD
- General Medicine
Analysis provides reassurance about intermediate-term safety.- Reviewing:
- Black DM et al., N Engl J Med 2010 Mar 24;:
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Be Still My Heart — Bisphosphonates Not Linked to Arrhythmias
- April 17, 2008
- Wendy S. Biggs, MD
- Women's Health
Use of oral bisphosphonates did not increase risk for atrial fibrillation and flutter.- Reviewing:
- Sørensen HT et al., BMJ 2008 Apr 12; 336:813.
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Oral Bisphosphonates Do Not Increase Risk for Atrial Fibrillation and Flutter
- April 8, 2008
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
A previous finding of increased risk for atrial fibrillation and flutter after IV bisphosphonate was not observed in orally treated patients.- Reviewing:
- Sørensen HT et al., BMJ 2008 Mar 11;:
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FDA Questions Whether Long-Term Use of Bisphosphonates Provides Fracture Benefit Free
- May 10, 2012
- Physician's First Watch
An FDA analysis, published in the New England Journal of Medicine, calls into question the fracture-prevention benefits of long-term bisphosphonate use.The FDA... -
Atypical Femur Fractures with Bisphosphonates
- December 29, 2011
- Allan S. Brett, MD
- General Medicine
Risk is low but not inconsequential. -
FDA: Data Inconclusive on Link Between Bisphosphonates and Esophageal Cancer Free
- July 22, 2011
- Physician's First Watch
Evidence is inconclusive on a possible association between the use of oral bisphosphonates and an increased risk for esophageal cancer, the FDA said Thursday. The... -
Bisphosphonates and Atypical Fractures: New Data from Sweden Free
- May 4, 2011
- Andrew M. Kaunitz, MD
- Women's Health
Relative risk was higher among bisphosphonate users, but absolute risk was small; risk fell rapidly after drug discontinuation.- Reviewing:
- Schilcher J et al., N Engl J Med 2011 May 5; 364:1728.
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More About Bisphosphonates and Atypical Femur Fractures
- March 3, 2011
- Allan S. Brett, MD
- General Medicine
Long-term bisphosphonate use was associated with a small increase in relative risk.
CME Exam- Reviewing:
- Park-Wyllie LY et al., JAMA 2011 Feb 23; 305:783.
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FDA Says Bisphosphonates Might Increase Femoral Fracture Risk, Orders Label Change Free
- October 14, 2010
- Physician's First Watch
In contrast with earlier reassurance that there was no "clear connection" between use of bisphosphonates and atypical femoral fractures, the FDA now says labeling changes... -
New Study Links Oral Bisphosphonates to Esophageal Cancer Free
- September 3, 2010
- Physician's First Watch
A case-control study in BMJ finds that oral bisphosphonates are associated with increased risk for esophageal cancer, thus contradicting a recent JAMA study finding... -
Bisphosphonates Not Associated with Risk for Esophageal, Gastric Cancers Free
- August 11, 2010
- Physician's First Watch
Despite reports suggesting a potential link between oral bisphosphonates and esophageal cancer, the drugs do not appear to pose increased risk, according to a case... -
Bisphosphonates' Link with Atypical Femur Fractures Inconclusive Free
- March 25, 2010
- Physician's First Watch
Femoral-shaft fractures associated with the use of bisphosphonate drugs are rare, an industry-supported study finds. However, the study's statistical power was too low... -
Possible Link Between Oral Bisphosphonates and Atypical Femur Fractures Is Far from Clear
- March 18, 2010
- Andrew M. Kaunitz, MD
- Women's Health
FDA advises that patients who use bisphosphonates for osteoporosis can continue to do so.
CME Exam -
Oral Bisphosphonates and Osteonecrosis of the Jaw: A Case Series
- December 15, 2009
- Allan S. Brett, MD
- General Medicine
The most common triggering events were tooth extractions and tooth implants.- Reviewing:
- Favia G et al., J Rheumatol 2009 Dec; 36:2780.
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Bisphosphonates Associated with Reduced Risk for Breast Cancer Free
- December 11, 2009
- Physician's First Watch
Patients may ask about two widely reported studies suggesting that oral bisphosphonates are associated with a 30% reduction in breast cancer risk. The studies — a... -
Is Monitoring BMD Necessary in Patients Who Take Bisphosphonates?
- July 23, 2009
- Wendy S. Biggs, MD
- Women's Health
Alendronate treatment increases bone density in most patients, so routine monitoring of BMD is not warranted.- Reviewing:
- Bell KJL et al., BMJ 2009 Jun 23; 338:b2266.
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Bisphosphonates for Glucocorticoid Users: Yearly or Daily?
- May 21, 2009
- Anna Wald, MD, MPH
- Women's Health
Yearly intravenous zoledronic acid was not inferior to daily oral risedronate.- Reviewing:
- Reid DM et al., Lancet 2009 Apr 11; 373:1253. Gennari L and Bilezikian JP., Lancet 2009 Apr 11; 373:1225.
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The HORIZON Study: Bisphosphonates for Patients on Corticosteroids Free
- May 1, 2009
- Jeffrey P. Callen, MD
- Dermatology
Once-yearly infusion of a bisphosphonate may be more effective and more convenient than daily bisphosphonate for preventing and treating glucocorticortoid-induced osteroporosis.- Reviewing:
- Reid DM et al., Lancet 2009 Apr 11; 373:1253. Gennari L and Bilezikian JP., Lancet 2009 Apr 11; 373:1225.
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Should We Be Concerned About Jaw Osteonecrosis with Oral Bisphosphonates? Free
- April 8, 2008
- Allan S. Brett, MD, and Peter B. Lockhart, DDS
- General Medicine
BRONJ probably occurs rarely with oral bisphosphonate therapy, but the true incidence isn't clear yet.
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