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Search for beta-agonists in all Journal Watch editions
Physician-authored summaries on the latest research on beta-agonists, editorials on beta-agonists, and perspectives on beta-agonists - drawn from the top medical journals.
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Effects of Long-Acting β-Agonists in Children with Asthma Free
- September 6, 2006
- Howard Bauchner, MD
- Pediatrics and Adolescent Medicine
They increase the risk for asthma exacerbations requiring hospitalization.- Reviewing:
- Salpeter SR et al., Ann Intern Med 2006 Jun 20; 144:904-12. Glassroth J., Ann Intern Med 2006 Jun 20; 144:936-7.
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Asthmatic Children with Viral Respiratory Infection Symptoms Require More β2-Agonists
- October 19, 2011
- F. Bruder Stapleton, MD
- Pediatrics and Adolescent Medicine
At 24 hours, asthmatic children with VRI symptoms had received four more doses on average than those with no VRI symptoms.- Reviewing:
- Reuter K et al., J Pediatr 2011 Aug 19;:
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FDA Warns Against Sole Use of Long-Acting Beta Agonists in Asthma Free
- February 19, 2010
- Physician's First Watch
Long-acting beta agonists should not be used alone in asthma, the FDA warns. The drugs at issue include the single-agent LABAs Serevent and... -
Long-Acting β-Agonists May Not Increase Risk for Respiratory Death Free
- May 5, 2008
- Physician's First Watch
Use of long-acting β-agonists (LABAs) might not pose a higher risk for respiratory death in adults with COPD, contrary to previous studies, according... -
Long-Acting Inhaled β-Agonists and Mortality Free
- December 28, 2006
- General Medicine
Earlier in 2006, findings highlighted increased risk for asthma-related deaths; more recently, experts have suggested the risks were due to use of these medications without inhaled steroids. -
Relation Between β-Agonists and Asthma Mortality Varies
- March 1, 2005
- Keith I. Marton, MD
- General Medicine
Periodically, concerns are raised about adverse effects of asthma drugs, but most concerns have not been supported by definitive evidence. Researchers in the U.K. performed . . .- Reviewing:
- Anderson HR et al., BMJ 2005 Jan 15; 330:117-20.
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For Older COPD Patients, Long-Acting Beta Agonists May Offer Survival Advantage Free
- May 3, 2011
- Physician's First Watch
Older patients initially prescribed long-acting beta agonists for chronic obstructive pulmonary disease have a lower mortality rate than those prescribed long-acting anticholinergics, according... -
Settling the Controversy About Long-Acting β-Agonists?
Adverse events are rare when LABAs are prescribed appropriately.- Reviewing:
- Bateman E et al., Ann Intern Med 2008 Jun 3;: Weiss KB., Ann Intern Med 2008 Jun 3;:
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Tiotropium vs. Long-Acting β-Agonists for Older Patients with COPD
- May 31, 2011
- Jamaluddin Moloo, MD, MPH
- General Medicine
Mortality was higher among patients who received initial treatment with tiotropium.- Reviewing:
- Gershon A et al., Ann Intern Med 2011 May 3; 154:583.
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What's the Best Method for Delivering β-Agonists to Young Children?
- September 10, 2004
- Robert Dershewitz, MD, MSc
- General Medicine
Short-acting β-agonists are a mainstay of treatment for acute exacerbations of asthma. In this meta-analysis, researchers compared two ways of delivering β-agonists to young children: . . .- Reviewing:
- Castro-Rodriguez JA and Rodrigo GJ., J Pediatr 2004 Aug; 145:172-7. Smyth RL and Jones A., J Pediatr 2004 Aug; 145:151-2.
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IV β2-Agonists: Not the Way to Go in the ED
- December 30, 2002
- Charles V. Pollack, Jr., MA, MD, FACEP
- Emergency Medicine
A meta analysis found no evidence to support the use of IV β2-agonists for patients with severe asthma.- Reviewing:
- Travers AH et al., Chest 2002 Oct; 122:1200-7.
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Metered-Dose Inhalers for Delivering Inhaled Steroids and β2-Agonists
- November 13, 2001
- KI Marton
- General Medicine
There are numerous ways to deliver inhaled corticosteroids or β2-agonists to patients with asthma. Such devices vary in method and price, but do . . .- Reviewing:
- Brocklebank D et al., BMJ 2001 Oct 20; 323:
896 900 . Ram FSF et al., BMJ 2001 Oct 20; 323:901 905 .
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MORE ON BETA AGONISTS AND ASTHMA MORTALITY.
- March 29, 1994
- CM Mulrow
- General Medicine
Heavy use of inhaled beta agonists has been linked to an increased risk for death from asthma, but the nature of this link is controversial. . . .- Reviewing:
- Suissa S et al., Am J Respir Crit Care Med 1994 Mar; 149:
604 610 .
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TOLERANCE TO BETA-AGONISTS ERODES THEIR BENEFIT IN ASTHMA.
- October 27, 1992
- ALK
- General Medicine
Inhaled beta-2-adrenergic agonists are potent bronchodilators with a clear role in treating acute asthma exacerbations. However, two new studies add to the growing concern that . . .- Reviewing:
- O'Connor BJ et al., N Engl J Med 1992 Oct 22; 327:
1204 1208 . Cheung D et al., N Engl J Med 1992 Oct 22; 327:1198 1203 .
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Doubt Cast on Initial Dopamine Agonists for Parkinson Disease Free
- September 30, 2008
- J. Eric Ahlskog, MD, PhD
- Neurology
Initiating Parkinson disease treatment with the dopamine agonist bromocriptine conferred no long-term advantages over initial levodopa therapy.- Reviewing:
- Katzenschlager R et al., Neurology 2008 Aug 12; 71:474. Weiner WJ and Reich SG., Neurology 2008 Aug 12; 71:470.
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Adding Inhaled Steroids and Long-Acting β-Agonists to Tiotropium for COPD
- April 10, 2007
- Richard Saitz, MD, MPH, FACP, FASAM
- General Medicine
The combination improved lung function, hospitalization rates, and quality-of-life scores.- Reviewing:
- Aaron SD et al., Ann Intern Med 2007 Feb 19;:
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Gambling on Dopamine Agonists
- October 19, 2005
- Jonathan Silver, MD
- Psychiatry
Medications that increase the function of the neurotransmitter dopamine are the primary treatment for Parkinson disease (PD). Dopamine’s activity in the nucleus accumbens forms the . . .- Reviewing:
- Dodd ML et al., Arch Neurol 2005 Sep; 62:1377-81.
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Inhaled Long-Acting β2-Agonists in Asthma Treatment
- July 17, 2001
- WC Taylor
- General Medicine
In 2 blinded, randomized U.S. trials, researchers investigated the optimal role of the inhaled long-acting β2-agonist salmeterol in the treatment of patients with . . .- Reviewing:
- Lazarus SC et al., JAMA 2001 May 23; 285:
2583 2593 . Lemanske RF et al., JAMA 2001 May 23; 285:2594 2603 . Holgate ST., JAMA 2001 May 23; 285:2637 2639 .
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ASTHMA MORTALITY RISK FROM BETA-AGONISTS IS EXAGGERATED.
- October 29, 1993
- THL
- General Medicine
Last year, a study reporting increased mortality in patients taking beta-agonists for asthma caused considerable alarm, even though prior studies had yielded contradictory results (see . . .- Reviewing:
- Mullen M et al., JAMA 1993 Oct 20; 270:
1842 1845 .
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REGULAR USE OF INHALED BETA AGONISTS MAY BE HARMFUL IN ASTHMA.
- January 4, 1991
- ASB
- General Medicine
Inhaled beta agonists are a mainstay in the treatment of asthma, but an important question has not been settled: should these agents be used regularly . . .- Reviewing:
- Sears MR et al., Lancet 1990 Dec 8; 336:
1391 1396 .
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