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Search for antidepressants in all Journal Watch editions
Physician-authored summaries on the latest research on antidepressants, editorials on antidepressants, and perspectives on antidepressants - drawn from the top medical journals.
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You searched for: antidepressants
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Antidepressants Don't Always Aggravate Bipolar Illness
- April 29, 2013
- Peter Roy-Byrne, MD
- Psychiatry
Bipolar II patients who respond acutely to fluoxetine alone may be maintained on this monotherapy.- Reviewing:
- Amsterdam JD et al., Br J Psychiatry 2013 Apr; 202:301. Thase ME., Br J Psychiatry 2013 Apr; 202:251.
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Balancing Positive and Negative Effects of Antidepressants During Pregnancy Free
- June 11, 2012
- Barbara Geller, MD
- Psychiatry
Auditory sensory gating was impaired in infants whose mothers had prenatal anxiety but not in those whose mothers used antidepressants during pregnancy.- Reviewing:
- Hunter SK et al., Am J Psychiatry 2012 Jun 1; 169:616.
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Antidepressants for Patients with Parkinson Disease Free
- April 30, 2012
- Jonathan Silver, MD
- Psychiatry
A well-controlled, multicenter study suggests efficacy of paroxetine and venlafaxine.- Reviewing:
- Richard IH et al., Neurology 2012 Apr 17; 78:1229. Friedman JH and Weintraub D., Neurology 2012 Apr 17; 78:1198.
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Antidepressants in Dementia: To Stop or Not? Free
- April 13, 2012
- Jonathan Silver, MD
- Psychiatry
Some patients have increased symptoms after SSRI discontinuation, but most do well.- Reviewing:
- Bergh S et al., BMJ 2012 Mar 9; 344:e1566.
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Antidepressants Work, and Depression Severity Does Not Matter Free
- March 12, 2012
- Peter Roy-Byrne, MD
- Psychiatry
Effects are greatest in children, but are significant for all, in a study examining patient-level data from 41 studies focusing on two antidepressants.- Reviewing:
- Gibbons RD et al., Arch Gen Psychiatry 2012 March 5;:
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Antidepressants Are Promising for Depressed Patients with Comorbid Neurological Disorders Free
- June 27, 2011
- Jonathan Silver, MD
- Psychiatry
A meta-analysis finds few relevant studies, but they indicate some efficacy.
CME Exam- Reviewing:
- Price A et al., J Neurol Neurosurg Psychiatry 2011 May 10;:
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Antidepressants Decrease Suicide Risk in the Long Term Free
- June 20, 2011
- Peter Roy-Byrne, MD
- Psychiatry
Twenty-seven years of follow-up data from a typical patient population show that antidepressants reduce risk for suicide attempts and deaths.
CME Exam- Reviewing:
- Leon AC et al., J Clin Psychiatry 2011 May; 72:580.
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Antidepressants and Risks for Breast and Ovarian Cancer
- May 2, 2011
- Joel Yager, MD
- Psychiatry
A meta-analysis found a modest association, but studies associated with industry ties produced different results from those without such ties.- Reviewing:
- Cosgrove L et al., PLoS ONE 2011 Apr 6; 4:e18210.
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Rapid vs. Gradual Discontinuation of Antidepressants Free
- September 3, 2010
- Joel Yager, MD
- Psychiatry
Going slower is better.
CME Exam- Reviewing:
- Baldessarini RJ et al., Am J Psychiatry 2010 Aug; 167:934. Freedman R., Am J Psychiatry 2010 Aug; 167:886.
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Prior Authorization of Antidepressants: Effects on Patient Care
- May 4, 2009
- Peter Roy-Byrne, MD
- Psychiatry
A common strategy to control medical costs has subtle effects, but these might hit vulnerable populations hard.- Reviewing:
- Adams AS et al., Arch Intern Med 2009 Apr 27; 169:750.
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Long-Term Use of Antidepressants and Diabetes: Et tu, Antidepressant?
- May 4, 2009
- Joel Yager, MD
- Psychiatry
Analysis of a large database points to increased diabetes risk with long-term use of these medications at moderate-to-high doses.- Reviewing:
- Andersohn F et al., Am J Psychiatry 2009 Apr 1;:
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Benefits of Antidepressants in Fibromyalgia Free
- January 22, 2009
- Thomas L. Schwenk, MD
- General Medicine
Tricyclic antidepressants were effective in reducing pain, fatigue, and sleep disturbances.- Reviewing:
- Häuser W et al., JAMA 2009 Jan 14; 301:198.
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Do Antidepressants Make Patients Suicidal? Free
- January 29, 2007
- Steven Dubovsky, MD
- Psychiatry
Suicide attempts, but not suicides, may increase slightly, but the mechanism remains unclear.- Reviewing:
- Tiihonen J et al., Arch Gen Psychiatry 2006 Dec; 63:1358-67.
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Antidepressants Cross the Placenta
- March 22, 2006
- Steven Dubovsky, MD
- Psychiatry
Cord blood levels of two tricyclics were close to maternal levels.- Reviewing:
- Loughhead AM et al., Biol Psychiatry 2006 Feb 1; 59:287-90.
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Direct-to-Consumer Advertising of Antidepressants and Prescribing Behavior
- June 8, 2005
- Peter Roy-Byrne, MD
- Psychiatry
How has the rapid growth of direct-to-consumer (DTC) advertisements of prescription drugs in the U.S. affected physicians' prescribing behavior? In this randomized, controlled trial, actors . . .- Reviewing:
- Kravitz RL et al., JAMA 2005 Apr 27; 293:1995-2002.
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A Cautionary Note for Cardiac Patients Taking Antidepressants
- July 23, 2012
- Steven Dubovsky, MD
- Psychiatry
Although the news has been generally positive for the use of antidepressants, citalopram and nortriptyline are associated with heightened risk for out-of-hospital cardiac arrest.
CME Exam- Reviewing:
- Weeke P et al., Clin Pharmacol Ther 2012 Jul; 92:72.
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Antidepressants Linked to Shorter Gestation and Neonatal Seizures
- July 2, 2012
- Deborah Cowley, MD
- Psychiatry
In a large population, most women stopped antidepressants in pregnancy, but their continued use increased neonatal risks.- Reviewing:
- Hayes RM et al., Am J Obstet Gynecol 2012 Jul; 207:49.e1.
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Correction: Antidepressants for Patients with Parkinson Disease Free
- May 2, 2012
- The Editors
- Psychiatry
A correction to a summary published April 30, 2012 -
Commonly Used Antidepressants No More Effective Than Placebo in Patients with Alzheimer Disease Free
- July 19, 2011
- Physician's First Watch
Sertraline and mirtazapine, commonly used in depressed patients with Alzheimer disease, are no more effective than placebo, according to a Lancet study. In a double... -
Pathways to New, Fast-Acting, Nonmonoaminergic Antidepressants
- July 18, 2011
- Barbara Geller, MD
- Psychiatry
Animal research on the mechanism of action of NMDA receptor antagonists may lead to new treatment approaches.- Reviewing:
- Autry AE et al., Nature 2011 Jun 15; 475:91.
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