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Search for antibiotic therapy in all Journal Watch editions
Physician-authored summaries on the latest research on antibiotic therapy, editorials on antibiotic therapy, and perspectives on antibiotic therapy - drawn from the top medical journals.
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You searched for: antibiotic therapy
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Recent Antibiotic Therapy Worsens Outcomes in Gram-Negative Sepsis
- June 22, 2011
- Thomas Glück, MD
- Infectious Diseases
In a retrospective study, antibiotic exposure within the preceding 90 days was linked to infection with drug-resistant pathogens and was an independent risk factor for hospital mortality.- Reviewing:
- Johnson MT et al., Crit Care Med 2011 Apr 14;:
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Combination Empirical Antibiotic Therapy for Severe Sepsis?
- June 9, 2010
- Thomas Glück, MD
- Infectious Diseases
The rate of appropriate empirical antibiotic therapy was higher with combination treatment than with monotherapy.- Reviewing:
- Micek ST et al., Antimicrob Agents Chemother 2010 May; 54:1742.
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Gut E. coli Resistance Patterns and Antibiotic Therapy
- February 13, 2008
- Thomas Glück, MD
- Infectious Diseases
Resistant strains, present in low numbers before antibiotic therapy, increased significantly 2 to 7 days after treatment started.- Reviewing:
- Raum E et al., Clin Microbiol Infect 2008 Jan; 14:41.
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CAP: Guiding Therapy with Procalcitonin Levels?
- July 12, 2006
- Neil M. Ampel, MD
- Infectious Diseases
Compared with usual practice, initiation and discontinuation of antibiotics according to patients' procalcitonin levels yielded similar outcomes yet significantly reduced antibiotic exposure.- Reviewing:
- Christ-Crain M et al., Am J Respir Crit Care Med 2006 Jul 1; 174:84-93.
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Inappropriate Initial Empirical Antibiotic Therapy in Abdominal-Surgery Patients
- October 25, 2004
- Thomas Glück, MD
- Infectious Diseases
Various investigators have reported unfavorable outcomes for patients with severe infections who have received inappropriate initial empirical antibiotic therapy. However, little information is available on . . .- Reviewing:
- Krobot K et al., Eur J Clin Microbiol Infect Dis 2004 Sep; 23:682-7.
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Combination Antibiotic Therapy for Pneumococcal Bacteremia
- September 3, 2004
- Allan S. Brett, MD
- General Medicine
Retrospective data suggest that, compared with monotherapy, combination antibiotic therapy is associated with reduced mortality from bacteremic pneumococcal pneumonia. Now, in an international, prospective, observational . . .- Reviewing:
- Baddour LM et al., Am J Respir Crit Care Med 2004 Aug 15; 170:440-4.
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Short-Term Antibiotic Therapy Not Effective for Secondary Prevention of CAD
- November 21, 2003
- JoAnne M. Foody, MD
- Cardiology
Chlamydia pneumoniae infection has been associated with progression of coronary artery disease, but evidence regarding the effectiveness of antibiotic therapy for secondary prevention has . . .- Reviewing:
- O'Connor CM et al. for the Investigators in the WIZARD Study., JAMA 2003 Sep 17; 290:1459-66. Pislaru SV and Van de Werf F., JAMA 2003 Sep 17; 290:1515-6.
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Duration of Antibiotic Therapy for Cholangitis After Successful Endoscopic Biliary Drainage
- July 30, 2002
- Stuart Sherman, MD
- Gastroenterology
The mainstay of therapy for patients with acute cholangitis is drainage of an obstructed biliary tree. Antibiotic administration is a complementary treatment used to control . . .- Reviewing:
- van Lent AUG et al., Gastrointest Endosc 2002 Apr; 55:518-22.
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Antibiotic Therapy for Suspected Pneumonia in the ICU
- September 12, 2000
- AS Brett
- General Medicine
It is often difficult to distinguish between pneumonia, atelectasis, and pulmonary edema when patients in the intensive care unit develop infiltrates on chest x-rays. Because . . .- Reviewing:
- Singh N et al., Am J Respir Crit Care Med 2000 Aug; 162:
505 511 .
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Oral Antibiotic Therapy for Fever and Neutropenia
- September 1, 1999
- R Ellison
- Infectious Diseases
Intravenous (IV) antibiotic therapy has been the mainstay of treatment for oncology patients with chemotherapy-induced neutropenia and fever. However, recent data have suggested that a . . .- Reviewing:
- Freifeld A et al., N Engl J Med 1999 Jul 29; 341:
305 311 . Kern WV et al., N Engl J Med 1999 Jul 29; 341:312 318 . Finberg RW and Talcott JA., N Engl J Med 1999 Jul 29; 341:362 363 .
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Antibiotic Therapy for Infected Joint Prostheses
- December 1, 1998
- B Britigan
- Infectious Diseases
Optimal treatment of infected prosthetic joints involves removal of the infected prostheses and targeted antibiotic therapy. But what if the patient refuses or is for . . .- Reviewing:
- Segretti J et al., Clin Infect Dis 1998 Oct; 27:711-3.
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NO NEED TO DELAY ANTIBIOTIC THERAPY FOR STREP THROAT.
- December 21, 1990
- DMB
- General Medicine
Antibiotic therapy for group A beta-hemolytic streptococcal (GABHS) pharyngitis blunts the body's immune response to the organism. In view of this, some authorities have recommended . . .- Reviewing:
- Gerber MA et al., J Pediatr 1990 Dec; 117:
853 858 .
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Meta-Analysis: Antibiotics Safe and Effective for Uncomplicated Acute Appendicitis Free
- April 6, 2012
- Physician's First Watch
Antibiotics are safe and effective for the primary treatment of uncomplicated acute appendicitis, according to a BMJ meta-analysis.The analysis included four studies that... -
Is Oral Antibiotic Therapy Enough for Children with Acute Pyelonephritis?
- March 21, 2012
- Louis M. Bell, MD
- Pediatrics and Adolescent Medicine
A randomized trial failed to prove the noninferiority of oral antibiotic monotherapy, relative to sequential intravenous and oral therapy, but evidence supporting oral treatment alone as an option is accumulating.- Reviewing:
- Bocquet N et al., Pediatrics 2012 Feb; 129:e269.
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Duration of Risk for Clostridium difficile Infection After Antibiotic Use
- February 29, 2012
- Thomas Glück, MD
- Infectious Diseases
Risk was increased 7- to 10-fold during the first month after antibiotic therapy, and nearly 3-fold for the next 2 months.- Reviewing:
- Hensgens MPM et al., J Antimicrob Chemother 2012 Mar; 67:742.
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Cumulative Antibiotic Exposure Is Associated with Risk for C. difficile Infection Free
- July 13, 2011
- Neil M. Ampel, MD
- Infectious Diseases
In a retrospective study among hospitalized patients, higher cumulative dose, number, and duration of antibiotics were independently associated with greater risk.- Reviewing:
- Stevens V et al., Clin Infect Dis 2011 Jul 1; 53:42.
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Timing of Antibiotic Prophylaxis for Cesarean Delivery
- September 16, 2010
- Allison Bryant, MD, MPH
- Women's Health
The American College of Obstetricians and Gynecologists recommends that, when feasible, antimicrobial prophylaxis should be given within 1 hour of the start of surgery.- Reviewing:
- Committee on Obstetric Practice., Obstet Gynecol 2010 Sep; 116:791.
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Treating Urinary Tract Infections in Healthy Women — Less Is More Free
- March 10, 2010
- Stephen G. Baum, MD
- Infectious Diseases
Treatments based on dipstick results are as good as — and less expensive than — those based on culture.- Reviewing:
- Little P et al., BMJ 2010 Feb 5; 340:c199. Turner D et al., BMJ 2010 Feb 5; 340:c346. Leydon GM et al., BMJ 2010 Feb 5; 340:c279. Little P et al., BMJ 2010 Feb 5; 340:b5633. Mangin D., BMJ 2010 Feb 5; 340:c657.
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Complicated Intra-Abdominal Infection: Diagnosis and Management
- January 27, 2010
- Stephen G. Baum, MD
- Infectious Diseases
These guidelines update recommendations published in 2002 and 2003.- Reviewing:
- Solomkin JS et al., Clin Infect Dis 2010 Jan 15; 50:133.
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Long-Term Antibiotic Therapy for Bone and Joint Infections
- January 6, 2010
- Thomas Glück, MD
- Infectious Diseases
Two oral combination regimens — rifampicin/linezolid and rifampicin/trimethoprim sulfamethoxazole — performed equally well.- Reviewing:
- Nguyen S et al., Clin Microbiol Infect 2009 Dec; 15:1163.
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