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Search for antibiotic therapy in all Journal Watch editions
Physician-authored summaries on the latest research on antibiotic therapy, editorials on antibiotic therapy, and perspectives on antibiotic therapy - drawn from the top medical journals.
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You searched for: antibiotic therapy
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Recent Antibiotic Therapy Worsens Outcomes in Gram-Negative Sepsis
- June 22, 2011
- Thomas Glück, MD
- Infectious Diseases
In a retrospective study, antibiotic exposure within the preceding 90 days was linked to infection with drug-resistant pathogens and was an independent risk factor for hospital mortality.- Reviewing:
- Johnson MT et al., Crit Care Med 2011 Apr 14;:
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Combination Empirical Antibiotic Therapy for Severe Sepsis?
- June 9, 2010
- Thomas Glück, MD
- Infectious Diseases
The rate of appropriate empirical antibiotic therapy was higher with combination treatment than with monotherapy.- Reviewing:
- Micek ST et al., Antimicrob Agents Chemother 2010 May; 54:1742.
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Gut E. coli Resistance Patterns and Antibiotic Therapy
- February 13, 2008
- Thomas Glück, MD
- Infectious Diseases
Resistant strains, present in low numbers before antibiotic therapy, increased significantly 2 to 7 days after treatment started.- Reviewing:
- Raum E et al., Clin Microbiol Infect 2008 Jan; 14:41.
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CAP: Guiding Therapy with Procalcitonin Levels?
- July 12, 2006
- Neil M. Ampel, MD
- Infectious Diseases
Compared with usual practice, initiation and discontinuation of antibiotics according to patients' procalcitonin levels yielded similar outcomes yet significantly reduced antibiotic exposure.- Reviewing:
- Christ-Crain M et al., Am J Respir Crit Care Med 2006 Jul 1; 174:84-93.
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Inappropriate Initial Empirical Antibiotic Therapy in Abdominal-Surgery Patients
- October 25, 2004
- Thomas Glück, MD
- Infectious Diseases
Various investigators have reported unfavorable outcomes for patients with severe infections who have received inappropriate initial empirical antibiotic therapy. However, little information is available on . . .- Reviewing:
- Krobot K et al., Eur J Clin Microbiol Infect Dis 2004 Sep; 23:682-7.
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Combination Antibiotic Therapy for Pneumococcal Bacteremia
- September 3, 2004
- Allan S. Brett, MD
- General Medicine
Retrospective data suggest that, compared with monotherapy, combination antibiotic therapy is associated with reduced mortality from bacteremic pneumococcal pneumonia. Now, in an international, prospective, observational . . .- Reviewing:
- Baddour LM et al., Am J Respir Crit Care Med 2004 Aug 15; 170:440-4.
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Short-Term Antibiotic Therapy Not Effective for Secondary Prevention of CAD
- November 21, 2003
- JoAnne M. Foody, MD
- Cardiology
Chlamydia pneumoniae infection has been associated with progression of coronary artery disease, but evidence regarding the effectiveness of antibiotic therapy for secondary prevention has . . .- Reviewing:
- O'Connor CM et al. for the Investigators in the WIZARD Study., JAMA 2003 Sep 17; 290:1459-66. Pislaru SV and Van de Werf F., JAMA 2003 Sep 17; 290:1515-6.
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Duration of Antibiotic Therapy for Cholangitis After Successful Endoscopic Biliary Drainage
- July 30, 2002
- Stuart Sherman, MD
- Gastroenterology
The mainstay of therapy for patients with acute cholangitis is drainage of an obstructed biliary tree. Antibiotic administration is a complementary treatment used to control . . .- Reviewing:
- van Lent AUG et al., Gastrointest Endosc 2002 Apr; 55:518-22.
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Antibiotic Therapy for Suspected Pneumonia in the ICU
- September 12, 2000
- AS Brett
- General Medicine
It is often difficult to distinguish between pneumonia, atelectasis, and pulmonary edema when patients in the intensive care unit develop infiltrates on chest x-rays. Because . . .- Reviewing:
- Singh N et al., Am J Respir Crit Care Med 2000 Aug; 162:
505 511 .
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Oral Antibiotic Therapy for Fever and Neutropenia
- September 1, 1999
- R Ellison
- Infectious Diseases
Intravenous (IV) antibiotic therapy has been the mainstay of treatment for oncology patients with chemotherapy-induced neutropenia and fever. However, recent data have suggested that a . . .- Reviewing:
- Freifeld A et al., N Engl J Med 1999 Jul 29; 341:
305 311 . Kern WV et al., N Engl J Med 1999 Jul 29; 341:312 318 . Finberg RW and Talcott JA., N Engl J Med 1999 Jul 29; 341:362 363 .
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Antibiotic Therapy for Infected Joint Prostheses
- December 1, 1998
- B Britigan
- Infectious Diseases
Optimal treatment of infected prosthetic joints involves removal of the infected prostheses and targeted antibiotic therapy. But what if the patient refuses or is for . . .- Reviewing:
- Segretti J et al., Clin Infect Dis 1998 Oct; 27:711-3.
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NO NEED TO DELAY ANTIBIOTIC THERAPY FOR STREP THROAT.
- December 21, 1990
- DMB
- General Medicine
Antibiotic therapy for group A beta-hemolytic streptococcal (GABHS) pharyngitis blunts the body's immune response to the organism. In view of this, some authorities have recommended . . .- Reviewing:
- Gerber MA et al., J Pediatr 1990 Dec; 117:
853 858 .
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Incomplete Recovery of the Gut Microbiome After Antibiotic Therapy in Infants
- December 5, 2012
- Thomas Glück, MD
- Infectious Diseases
Antibiotic use in infants causes changes in the gut microbiome that persist for at least 8 weeks.- Reviewing:
- Fouhy F et al., Antimicrob Agents Chemother 2012 Nov; 56:5811.
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Pediatric-Specific Antibiotic Susceptibilities Differ from Adult Antibiograms
- September 26, 2012
- Louis M. Bell, MD
- Pediatrics and Adolescent Medicine
Knowledge of pediatric-specific antibiotic susceptibilities could improve our ability to choose appropriate empiric antibiotics for childhood infections.- Reviewing:
- Boggan JC et al., Pediatrics 2012 Sep; 130:e615.
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Procalcitonin-Guided Antibiotic Use in the Critically Ill — No Benefit
- September 12, 2012
- Thomas Glück, MD
- Infectious Diseases
In a prospective, randomized study, procalcitonin measurement did not reduce antibiotic use or shorten treatment courses.- Reviewing:
- Layios N et al., Crit Care Med 2012 Aug; 40:2304.
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Infant Mice Get Fat When Exposed to Antibiotics
- September 5, 2012
- Richard T. Ellison III, MD
- Infectious Diseases
Are there implications for the childhood obesity epidemic?- Reviewing:
- Cho I et al., Nature 2012 Aug 30; 488:621.
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Adding Zinc to Antibiotics Reduces Treatment Failures
- June 13, 2012
- Mary E. Wilson, MD
- Infectious Diseases
Among infants with probable bacterial infection, adjunctive zinc decreased the need to change therapy, the need for intensive care, and the risk for death.- Reviewing:
- Bhatnagar S et al., Lancet 2012 Jun 2; 379:2072. Walker CLF and Black RE., Lancet 2012 Jun 2; 379:2031.
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Monotherapy for Patients with Severe Sepsis?
- May 30, 2012
- Richard T. Ellison III, MD
- Infectious Diseases
Outcomes were similar between meropenem alone and meropenem plus moxifloxacin.- Reviewing:
- Brunkhorst FM et al., JAMA 2012 May 21;:
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Management of Early-Onset Neonatal Sepsis
- May 30, 2012
- Robert S. Baltimore, MD
- Infectious Diseases
Suspected sepsis during the first 3 days of life is common; antibiotic use can be minimized by reducing treatment duration when the probability of sepsis is low.- Reviewing:
- Polin RA et al., Pediatrics 2012 May; 129:1006.
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Can Broad-Spectrum Antibiotics Be De-Escalated in Sepsis?
- May 23, 2012
- Thomas Glück, MD
- Infectious Diseases
Infectious diseases specialist–assisted de-escalation of anti-infective treatment was possible in 43% of patients with severe sepsis.- Reviewing:
- Heenen S et al., Crit Care Med 2012 May; 40:1404.
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