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Search for LDL cholesterol in all Journal Watch editions
Physician-authored summaries on the latest research on LDL cholesterol, editorials on LDL cholesterol, and perspectives on LDL cholesterol - drawn from the top medical journals.
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You searched for: LDL cholesterol
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Evacetrapib Raises HDL and Lowers LDL — but Then What?
- November 15, 2011
- JoAnne M. Foody, MD
- Cardiology
The cholesterol ester transfer protein inhibitor evacetrapib had very favorable lipid effects, but the trial was small and lasted only 12 weeks.- Reviewing:
- Nicholls SJ et al., JAMA 2011 Nov 16; 306:2099. Cannon CP., JAMA 2011 Nov 16; 306:2153.
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Simvastatin plus Ezetimibe Improves Cardiovascular Outcomes in Patients with Chronic Kidney Disease Free
- June 9, 2011
- Harlan M. Krumholz, MD, SM
and Allan S. Brett, MD - General Medicine
But would a statin alone have produced similar results?
CME Exam- Reviewing:
- Baigent C et al., Lancet 2011 Jun 9;: Stevens KK and Jardine AG., Lancet 2011 Jun 9;:
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Statins Sharply Lower Cardiovascular Risk Regardless of Baseline LDL Cholesterol Free
- December 16, 2010
- Bruce Soloway, MD
- General Medicine
Results of a meta-analysis suggest that guidelines should be reevaluated.
CME Exam- Reviewing:
- Cholesterol Treatment Trialists' (CTT) Collaboration., Lancet 2010 Nov 13; 376:1670. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group., Lancet 2010 Nov 13; 376:1658. Cheung BMY and Lam KSL., Lancet 2010 Nov 13; 376:1622.
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Independent Effects of LDL Cholesterol and hsCRP Lowering in the JUPITER Trial
- April 23, 2009
- Bruce Soloway, MD
- General Medicine
Greater hsCRP reductions correlated with improved cardiovascular outcomes.- Reviewing:
- Ridker PM et al., Lancet 2009 Apr 4; 373:1175.
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How Low Should We Go (with BP and Cholesterol in Diabetic Patients)?
- April 24, 2008
- Thomas L. Schwenk, MD
- General Medicine
Lower might be better, but more clinical data are needed.
Audio Interview- Reviewing:
- Howard BV et al., JAMA 2008 Apr 9; 299:1678.
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Does HDL Matter When Statins Are Working? Free
- September 26, 2007
- Harlan M. Krumholz, MD, SM
- Cardiology
In a post hoc analysis of TNT trial data, HDL levels predicted cardiovascular events in patients with very low LDL levels.- Reviewing:
- Barter P et al. for the Treating to New Targets Investigators., N Engl J Med 2007 Sep 27; 357:1301.
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HDL Levels and Cardiovascular Risk in Patients with Very Low LDL Levels Free
- September 26, 2007
- Allan S. Brett, MD
- General Medicine
HDL level was inversely correlated with cardiovascular events, regardless of LDL level.- Reviewing:
- Barter P et al., N Engl J Med 2007 Sep 27; 357:1301.
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Combined Therapy with Ezetimibe Plus Statin
- June 14, 2005
- Allan S. Brett, MD
- General Medicine
When added to a statin, the cholesterol absorption inhibitor ezetimibe (Zetia) results in additional lowering of blood cholesterol. In this community-based, manufacturer-sponsored, randomized trial, researchers . . .- Reviewing:
- Pearson TA et al., Mayo Clin Proc 2005 May; 80:587-95. Hurley DL and Isley WL., Mayo Clin Proc 2005 May; 80:585-6.
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CRP and Outcomes After Statin Therapy
- January 14, 2005
- Allan S. Brett, MD
- General Medicine
Lower CRP levels after statin therapy are associated with improved outcomes, but what do these findings mean for the future of statin therapy?- Reviewing:
- Ridker PM et al., N Engl J Med 2005 Jan 6; 352:20-8. Nissen SE et al. , N Engl J Med 2005 Jan 6; 352:29-38.
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More Evidence Favors PCSK9 as a Target in Lipid Management Free
- November 7, 2012
- Physician's First Watch
A new PCSK9 inhibitor — the monoclonal antibody AMG 145 — helps reduce LDL levels in patients with dyslipidemia, according to two studies presented at the American... -
Lower LDL Cholesterol Level and Risk for CHD Later in Life
- November 6, 2012
- Kirsten E. Fleischmann, MD, MPH
- General Medicine
Coronary heart disease in midlife was uncommon in people with genetically low LDL cholesterol levels.- Reviewing:
- Ference BA et al., J Am Coll Cardiol 2012 Oct 9;: Steinberg D and Grundy SM., J Am Coll Cardiol 2012 Oct 9;:
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Niacin Is Ineffective in Patients with Established Cardiovascular Disease Free
- November 15, 2011
- Allan S. Brett, MD
- General Medicine
Niacin plus simvastatin was no better than simvastatin alone.
CME Exam- Reviewing:
- The AIM-HIGH Investigators., N Engl J Med 2011 Nov 15;:
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Xanthelasma, but Not Arcus Senilis, Predicts Atherosclerotic Vascular Disease and Death
- October 21, 2011
- Jeffrey P. Callen, MD
- Dermatology
A relatively common clinical finding is a marker of increased risk for cardiovascular disease.- Reviewing:
- Christoffersen M et al., BMJ 2011 Sep 15; 343:d5497.
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Bariatric Surgery: Gastric Bypass vs. Duodenal Switch
- October 11, 2011
- Jamaluddin Moloo, MD, MPH
- General Medicine
Duodenal switch patients lost more weight but experienced more adverse effects.- Reviewing:
- Søvik TT et al., Ann Intern Med 2011 Sep 6; 155:281. Livingston EH., Ann Intern Med 2011 Sep 6; 155:329.
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A Direct Comparison of Bariatric Surgery Types Yields No Clear Winner
- October 5, 2011
- Joel M. Gore, MD
- Cardiology
Reduction in some cardiovascular risk factors was greater with duodenal switch than with gastric bypass, but so was the incidence of adverse events.- Reviewing:
- Søvik TT et al., Ann Intern Med 2011 Sep 6; 155:281.
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More Frequent Office Visits Might Hasten Control of Vascular Risk Factors in Diabetes Free
- September 27, 2011
- Physician's First Watch
In diabetes, more frequent encounters with primary care clinicians are associated with better control of vascular risk factors, according to an Archives of Internal Medicine... -
'Million Hearts' Initiative Aims to Widen Use of Evidence-Based Prevention Strategies Free
- September 14, 2011
- Physician's First Watch
The U.S. has embarked on the "Million Hearts" program to reduce the number of heart attacks and strokes by 1 million over the next 5... -
Duodenal Switch Surgery Riskier Than Gastric Bypass Free
- September 6, 2011
- Physician's First Watch
The first randomized comparison of gastric bypass and duodenal switch surgery, published in the Annals of Internal Medicine, shows greater weight loss and improvements in... -
Cholesterol-Lowering Foods vs. Low-Fat Diet to Reduce LDL Levels Free
- August 29, 2011
- Physician's First Watch
A diet rich in four cholesterol-lowering foods — soy protein, plant sterols, viscous fiber, and nuts — can reduce LDL levels more effectively than a diet... -
Does Waist Circumference Measure Up? Free
Independent of body-mass index, increases in waist circumference predicted changes in cardiovascular disease risk factors in postmenarcheal white adolescents.- Reviewing:
- Tybor DJ et al., Am J Clin Nutr 2011 Feb; 93:392.
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