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Search for HCV in all Journal Watch editions
Physician-authored summaries on the latest research on HCV, editorials on HCV, and perspectives on HCV - drawn from the top medical journals.
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Transplant-Associated HCV Transmission
- January 11, 2012
- Stephen G. Baum, MD
- Infectious Diseases
Stricter guidelines or more-careful adherence to current ones might have prevented hepatitis C virus transmission to kidney and cardiopulmonary-patch recipients.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Dec 23; 60:1697.
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Liver Fibrosis Progression After Acute HCV Infection in HIV-Positive Patients
- December 22, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
The rate of fibrosis progression is initially rapid but subsequently seems to slow down.- Reviewing:
- Vogel M et al., Clin Infect Dis 2011 Dec 7;:
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Adherence to HCV Therapy Is Associated with Virologic Response
- October 21, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Patients with better adherence to peginterferon and ribavirin showed better early and sustained virologic responses to HCV infection.- Reviewing:
- Lo Re V III et al., Ann Intern Med 2011 Sep 20; 155:353.
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Adherence to Hepatitis C Virus Therapy Improves Virologic Outcomes
- October 13, 2011
- Jamaluddin Moloo, MD, MPH
- General Medicine
At least for patients with genotype 1 or 4 infections, adhering to therapy improves response rates.- Reviewing:
- Lo Re V III et al., Ann Intern Med 2011 Sep 20; 155:353.
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Interferon-Free Regimen Shows Promise for Chronic HCV Infection Free
- September 30, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
In a phase Ib trial, the combination of a polymerase inhibitor, a protease inhibitor, and ribavirin demonstrated potent antiviral activity.- Reviewing:
- Zeuzem S et al., Gastroenterology 2011 Sep 16;:
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Telaprevir Therapy for 24 Weeks Appropriate for Many with HCV Infection
- September 16, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Response-guided treatment with telaprevir, peginterferon alfa-2a, and ribavirin for 24 weeks was noninferior to the standard 48-week course in patients with hepatitis C virus infection.
CME Exam- Reviewing:
- Sherman KE et al., N Engl J Med 2011 Sep 15; 365:1014.
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HCV Transmission in HIV-Positive MSM — Sex, Not Just Drugs
- August 8, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
High-risk sexual behavior is associated with HCV transmission among HIV-positive men who have sex with men.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Jul 22; 60:945.
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Telaprevir Markedly Improves HCV Genotype 1 Cure Rates
- July 1, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Final results of phase III trials show that telaprevir plus standard therapy with peginterferon alfa-2a and ribavirin was more effective than standard therapy alone.- Reviewing:
- Jacobson IM et al., N Engl J Med 2011 Jun 23; 364:2405. Zeuzem S et al., N Engl J Med 2011 Jun 23; 364:2417.
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Telaprevir Isn't Useful for All HCV Genotypes Free
- June 10, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Telaprevir-based triple therapy showed some promise against hepatitis C virus genotype 2 infection but had limited activity against genotype 3 infection.- Reviewing:
- Foster GR et al., Gastroenterology 2011 Jun 1;:
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Community-Based Primary Care Treatment of HCV Infection
- June 9, 2011
- Thomas L. Schwenk, MD
- General Medicine
PCPs treated hepatitis C virus infections as safely and effectively as multidisciplinary specialty care providers.- Reviewing:
- Arora S et al., N Engl J Med 2011 Jun 9; 364:2199. Sequist TD., N Engl J Med 2011 Jun 9; 364:2258.
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Triple Therapy for Chronic Hepatitis C Virus Infection Free
- March 30, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Adding boceprevir to standard peginterferon and ribavirin therapy dramatically improved sustained virologic response.- Reviewing:
- Poordad F et al., N Engl J Med 2011 Mar 31; 364:1195. Bacon BR et al., N Engl J Med 2011 Mar 31; 364:1207. Jensen DM., N Engl J Med 2011 Mar 31; 364:1272.
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HCV Infection in HIV-Positive MSM
- February 28, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
In HIV-positive men who have sex with men, HCV acquisition is not uncommon and is often due to sexual exposure.- Reviewing:
- Tayor LE et al., Clin Infect Dis 2011 Jan 31;: Matthews GV et al., Clin Infect Dis 2011 Jan 31;: The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel., AIDS 2011 Feb 20; 25:399.
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Liver Cancer Screening in Patients with HCV Infection
- February 25, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Few U.S. veterans with hepatitis C virus infection and cirrhosis received recommended surveillance.
CME Exam- Reviewing:
- Davila JA et al., Ann Intern Med 2011 Jan 18; 154:85.
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Pegylated Interferon-Lambda for Chronic Hepatitis C Virus Infection
- December 22, 2010
- David A. Johnson, MD
- Gastroenterology
In a phase Ib study, PEG-IFN-λ showed promise in both treatment-naive and relapsing patients.- Reviewing:
- Muir AJ et al., Hepatology 2010 Sep; 52:822.
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Treatment Response in Patients with Hepatitis C Virus–Related Cirrhosis
- December 22, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Patients who achieved sustained virologic response had increased likelihood of event-free and overall survival.- Reviewing:
- Fernández-Rodríguez CM et al., Am J Gastroenterol 2010 Oct; 105:2164.
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Genetic Testing for Hepatitis C Virus Genotype 2 or 3 Infection Free
- November 5, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
IL28B genotype was an independent predictor of sustained virologic response to HCV therapy.
CME Exam- Reviewing:
- Mangia A et al., Gastroenterology 2010 Sep; 139:821.
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Maintenance Interferon in HIV/HCV-Coinfected Patients: The SLAM-C Trial
- November 1, 2010
- Rajesh T. Gandhi, MD
- HIV/AIDS
Slower-than-expected progression of hepatic fibrosis resulted in the trial being stopped early.- Reviewing:
- Sherman K et al., J Acquir Immune Defic Syndr 2010 Oct 1;:
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Explaining the HCV Epidemic Among Drug Users
- October 19, 2010
- Abigail Zuger, MD
- General Medicine
Hepatitis C virus can live in syringes for longer than 2 months.- Reviewing:
- Paintsil E et al., J Infect Dis 2010 Oct 1; 202:984. Rich JD and Taylor LE., J Infect Dis 2010 Oct 1; 202:981.
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HCV Transmission by Intravenous Therapy in Central Africa
- October 13, 2010
- Neil M. Ampel, MD
- Infectious Diseases
Among older individuals in Cameroon, IV therapy for malaria during the colonial era was associated with hepatitis C virus seropositivity.- Reviewing:
- Pépin J et al., Clin Infect Dis 2010 Oct 1; 51:768.
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Hepatitis C Virus Survival in Syringes
- September 8, 2010
- Rajesh T. Gandhi, MD
- Infectious Diseases
Under certain conditions, HCV can survive longer than 2 months.- Reviewing:
- Paintsil E et al., J Infect Dis 2010 Oct 1; 202:984. Rich JD and Taylor LE., J Infect Dis 2010 Oct 1; 202:981.
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