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Search for BRCA mutations in all Journal Watch editions
Physician-authored summaries on the latest research on BRCA mutations, editorials on BRCA mutations, and perspectives on BRCA mutations - drawn from the top medical journals.
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You searched for: BRCA mutations
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When BRCA Mutations Run in the Family, Should Noncarriers Worry? Free
- November 17, 2011
- Andrew M. Kaunitz, MD
- Women's Health
Population-based study shows that noncarriers are not at excess risk for breast cancer attributable to familial mutations.- Reviewing:
- Kurian AW et al., J Clin Oncol 2011 Oct 31;: Robson M., J Clin Oncol 2011 Oct 31;:
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Testing for BRCA Mutations: Should Criteria Be Broadened?
- September 16, 2010
- Andrew M. Kaunitz, MD
- Women's Health
Offering testing to women who are younger than 50 and have triple-negative breast cancer is cost-effective.- Reviewing:
- Kwon JS et al., J Clin Oncol 2010 Aug 23;:
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Olaparib for Cancers Associated with BRCA Mutations
- August 4, 2009
- Virginia Kaklamani, MD, DSc
- Oncology and Hematology
The poly(adenosine diphosphate ribose) polymerase inhibitor olaparib showed antitumor activity in patients with BRCA1- and BRCA2-associated malignancies.- Reviewing:
- Fong PC et al., N Engl J Med 2009 Jul 9; 361:123. Iglehart JD and Silver DP., N Engl J Med 2009 Jul 9; 361:189.
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Ductal Carcinoma in Situ: Similar Incidence in Women With or Without BRCA Mutations
- March 1, 2007
- Andrew M. Kaunitz, MD
- Women's Health
DCIS should be considered in models that predict risk for BRCA mutations.- Reviewing:
- Hwang ES et al., J Clin Oncol 2007 Feb 20; 25:642-7.
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Bilateral Oophorectomy Reduces Breast and Ovarian Cancer Risk in Women with BRCA Mutations
- July 23, 2002
- Andrew M. Kaunitz, MD
- Women's Health
Identification of BRCA genes and the availability of genetic testing have focused attention on reducing cancer risk in women with BRCA mutations. In 2 recent . . .- Reviewing:
- Kauff ND et al., N Engl J Med 2002 May 23; 346:1609-15. Rebbeck TR et al., N Engl J Med 2002 May 23; 346:1616-22. Haber D., N Engl J Med 2002 May 23; 346:1660-2.
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Do BRCA Mutations Influence Ovarian Cancer Outcomes?
- November 8, 2011
- Virginia Kaklamani, MD, DSc
- Oncology and Hematology
Sensitivity to platinum-based chemotherapy and overall survival were better among patients with BRCA2 mutations than among those with BRCA1 mutations or wild-type BRCA.- Reviewing:
- Yang D et al., JAMA 2011 Oct 12; 306:1557.
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Bilateral Salpingo-Oophorectomy in Women with BRCA Mutations
- February 19, 2009
- Andrew M. Kaunitz, MD
- Women's Health
BSO is effective in lowering risk for breast, ovarian, and tubal cancers.
CME Exam- Reviewing:
- Rebbeck TR et al., J Natl Cancer Inst 2009 Jan 21; 101:80. Greene MH and Mai PL., J Natl Cancer Inst 2009 Jan 21; 101:70.
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Preventing Ovarian Cancer in Patients with BRCA Mutations
- August 8, 2006
- Thomas L. Schwenk, MD, and Robert W. Rebar, MD
- General Medicine
Prophylactic salpingo-oophorectomy appears to reduce the risk for ovarian cancer, but peritoneal cancer may still develop.- Reviewing:
- Finch A et al., JAMA 2006 Jul 12; 296:185-92.
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BRCA Mutations Associated with DCIS
- April 19, 2005
- Andrew M. Kaunitz, MD
- Women's Health
The prevalence of BRCA1 and BRCA2 mutations among women with invasive breast cancer is well studied, but their prevalence among women with noninvasive breast cancer . . .- Reviewing:
- Claus EB et al., JAMA 2005 Feb 23; 293:964-9.
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Prophylactic Oophorectomy in Women with BRCA Mutations
- July 30, 2002
- Robert W. Rebar, MD
- Gastroenterology
Women who have inactivating mutations in the BRCA1 or BRCA2 genes have higher risks for breast and ovarian cancer. In 2 studies, investigators evaluated whether . . .- Reviewing:
- Kauff ND et al., N Engl J Med 2002 May 23; 346:1609-15. Rebbeck TR et al., N Engl J Med 2002 May 23; 346:1616-22. Haber D., N Engl J Med 2002 May 23; 346:1660-2.
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Does OC Use Reduce Ovarian Cancer Risk in Women with BRCA Mutations?
- October 3, 2001
- AM Kaunitz
- Women's Health
Low parity and infertility are established risk factors for nonfamilial ovarian cancer; multiparity and oral contraceptive (OC) use can reduce the risk for this uncommon . . .- Reviewing:
- Modan B et al., N Engl J Med 2001 Jul 26; 345:
235 240 .
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OCs and Ovarian Cancer Risk with BRCA Mutations
- September 1, 1998
- W Levinson
- Women's Health
Only 10% of ovarian cancer is hereditary, but many studies have examined women in this subgroup. Unselected long-term OC users have a 50% reduced ovarian . . .- Reviewing:
- Narod SA et al., N Engl J Med 1998 Aug 13; 339:
424 428 . Rubin SC., N Engl J Med 1998 Aug 13; 339:469 471 .
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BRCA Testing of Women with Ovarian Cancer: Which Strategy Is Best?
- November 19, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Testing women of Ashkenazi Jewish ancestry or with family histories of breast or ovarian cancer was projected to be cost-effective for lowering subsequent cancer rates among first-degree relatives.- Reviewing:
- Kwon JS et al., J Clin Oncol 2009 Oct 19;:
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Are Supplemental Screening Ultrasonography and MRI Worthwhile in Women with Excess Risk for Breast Cancer? Free
- April 12, 2012
- Andrew M. Kaunitz, MD
- Women's Health
Sensitivity was increased, but so were false-positive rates.- Reviewing:
- Berg WA et al., JAMA 2012 Apr 4; 307:1394.
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Hereditary Breast and Ovarian Cancer: Earlier Onset with Each Generation Free
- September 22, 2011
- Andrew M. Kaunitz, MD
- Women's Health
Younger age at diagnosis in subsequent generations of BRCA carriers bespeaks the importance of early breast screening.
CME Exam- Reviewing:
- Litton JK et al., Cancer 2011 Sep 12;:
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Breast Cancer in Women Younger Than 25 Free
- September 15, 2011
- Andrew M. Kaunitz, MD
- Women's Health
Although cancer is uncommon in this age group, all breast masses should be evaluated.- Reviewing:
- Simmons PS et al., Obstet Gynecol 2011 Sep; 118:529.
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Can a Simple Risk-Factor Score Predict Ovarian Cancer Risk?
- June 2, 2011
- Andrew M. Kaunitz, MD
- Women's Health
The authors identified risk factors for ovarian cancer and developed a simple scoring system for assessing overall risk.
CME Exam- Reviewing:
- Vitonis AF et al., Obstet Gynecol 2011 May; 117:1042.
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Reasons Behind Rising Contralateral Prophylactic Mastectomy Rates
- April 26, 2011
- Henry Mark Kuerer, MD, PhD, FACS
- Oncology and Hematology
Factors related to treatment of index breast cancer influenced CPM choices.- Reviewing:
- King TA et al., J Clin Oncol 2011 Apr 4;: Khan SA., J Clin Oncol 2011 Apr 4;:
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Benefits of Risk-Reducing Surgeries in BRCA Carriers Estimated Free
- September 1, 2010
- Physician's First Watch
Women with BRCA mutations who undergo prophylactic mastectomy or salpingo-oophorectomy reduce their risks for breast and ovarian cancer, according to an observational study in... -
Missed Opportunities: Testing for BRCA1 and BRCA2 Mutations in Ovarian Cancer Patients
- June 10, 2010
- Ann J. Davis, MD
- Women's Health
Only half of ovarian cancer patients at substantial risk for BRCA mutations were referred for genetic counseling.- Reviewing:
- Meyer LA et al., Obstet Gynecol 2010 May; 115:945.
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