- Home>
- Journal Watch
- >
- Alzheimer's disease
Search for Alzheimer's disease in all Journal Watch editions
Physician-authored summaries on the latest research on Alzheimer's disease, editorials on Alzheimer's disease, and perspectives on Alzheimer's disease - drawn from the top medical journals.
Sort by:
Items 1 to 20 of 642 results - Relevance
- Date
You searched for: Alzheimer's disease
-
In Alzheimer Disease, Antioxidants Hurt
- April 23, 2012
- Jonathan Silver, MD
- Psychiatry
Antioxidants do not improve AD biomarkers and adversely affect cognition.- Reviewing:
- Galasko DR et al., Arch Neurol 2012 Mar 19;:
-
Drug Directed at ApoE Production is Successful in Mouse Models of Alzheimer Disease
- April 10, 2012
- Anthony L. Komaroff, MD
- General Medicine
Bexarotene — FDA-approved for cutaneous T-cell lymphomas — reversed neural pathology and cognitive deficits; too good to be true?- Reviewing:
- Cramer PE et al., Science 2012 Mar 23; 335:1503. Strittmatter WJ., Science 2012 Mar 23; 335:1447.
-
“Silent” Cerebral Emboli May Hasten Progression of Dementia Free
- April 5, 2012
- Allan S. Brett, MD
- General Medicine
This finding was noted both in patients with Alzheimer disease and those with vascular dementia.- Reviewing:
- Purandare N et al., Am J Psychiatry 2012 Mar 1; 169:300. Doraiswamy PM., Am J Psychiatry 2012 Mar 1; 169:251.
-
Alzheimer Disease and Cancer: An Inverse Relation?
- March 29, 2012
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Framingham data support this biologically plausible phenomenon.- Reviewing:
- Driver JA et al., BMJ 2012 Mar 12; 344:e1442.
-
A New Quick Way to Assess Alzheimer Disease
- March 26, 2012
- Jonathan Silver, MD
- Psychiatry
A neuropsychological test captures the episodic memory deficit associated with AD, even early in the disease process.- Reviewing:
- Wagner M et al., Neurology 2012 Feb 7; 78:379. Swerdlow RH and Jicha GA., Neurology 2012 Feb 7; 78:374.
-
Managing Drug Therapies as Alzheimer Disease Progresses
- March 20, 2012
- Allan S. Brett, MD
- General Medicine
After several years of donepezil therapy, donepezil (but not memantine) conferred modest benefits.
CME Exam- Reviewing:
- Howard R et al., N Engl J Med 2012 Mar 8; 366:893.
-
Treatment of Alzheimer Disease: Stop, Add, or Switch? Free
- March 7, 2012
- Jonathan Silver, MD
- Psychiatry
This randomized study finds little evidence of benefit from combining medications in patients with moderate-to-severe AD.- Reviewing:
- Howard R et al., N Engl J Med 2012 Mar 8; 366:893. Schneider LS., N Engl J Med 2012 Mar 8; 366:957.
-
Stem Cells Helpful for Studying Alzheimer Disease Pathology
- February 27, 2012
- Barbara Geller, MD
- Psychiatry
Using induced pluripotent stem cells allows a closer look at phenotypes in familial and sporadic AD.- Reviewing:
- Israel MA et al., Nature 2012 Jan 25;:
-
Timing of Biomarker Changes in Alzheimer Disease Process
- February 14, 2012
- Jennifer Rose V. Molano, MD
- Neurology
Abnormal amyloid biomarker levels may be seen before abnormal tau biomarker levels in patients progressing toward Alzheimer disease.- Reviewing:
- Jack CR Jr et al., Arch Neurol 2011 Dec; 68:1526.
-
Intranasal Insulin Therapy for AD and Amnestic MCI
- December 6, 2011
- Martin R. Farlow, MD
- Neurology
A pilot study suggests a benefit in maintaining cognition in patients with mild cognitive impairment or Alzheimer disease.- Reviewing:
- Craft S et al., Arch Neurol 2011 Sep 12;:
-
Divalproex Might Shrink the Brain Free
- October 24, 2011
- Jonathan Silver, MD
- Psychiatry
Patients with Alzheimer disease showed brain atrophy and cognitive problems in the first year of receiving divalproex.- Reviewing:
- Fleisher AS et al., Neurology 2011 Sep 27; 77:1263.
-
Predicting Conversion from Mild Cognitive Impairment to Alzheimer Disease
- October 4, 2011
- Brandy R. Matthews, MD
- Neurology
Cognitive and functional measures remain significant predictors of decline compared with other biomarkers.- Reviewing:
- Gomar JJ et al., Arch Gen Psychiatry 2011 Sep; 68:961.
-
Simvastatin Doesn't Benefit Patients with Alzheimer Disease
- August 30, 2011
- Allan S. Brett, MD
- General Medicine
Randomized trials failed to show that statins can prevent or treat Alzheimer disease.
CME Exam- Reviewing:
- Sano M et al., Neurology 2011 Aug 9; 77:556.
-
Valproate Does Not Prevent Agitation in Alzheimer Disease Patients
- August 29, 2011
- Steven Dubovsky, MD
- Psychiatry
On several measures, the drug performs worse than placebo.
CME Exam- Reviewing:
- Tariot PN et al. for the Alzheimer's Disease Cooperative Study Group., Arch Gen Psychiatry 2011 Aug; 68:853.
-
Nonmemory Symptoms Can Lead to Misdiagnosis in Early-Onset Alzheimer Disease Free
- June 14, 2011
- Brandy R. Matthews, MD
- Neurology
Initial and final diagnoses were incorrect in about half of patients with atypical presentations.- Reviewing:
- Balasa M et al., Neurology 2011 May 17; 76:1720.
-
A Supplement That Works for Alzheimer Disease?
- May 23, 2011
- Jonathan Silver, MD
- Psychiatry
Huperzine A may improve cognition.- Reviewing:
- Rafii MS et al for the Alzheimer's Disease Cooperative Study., Neurology 2011 Apr 19; 76:1389.
-
Memantine Is Not Effective for Mild Alzheimer Disease Free
- May 17, 2011
- Martin Rhys Farlow, MD
- Neurology
Off-label use of memantine for mild AD is not supported by the findings of a meta-analysis that focused specifically on patients with mild disease.- Reviewing:
- Schneider LS et al., Arch Neurol 2011 Apr 11;:
-
Updated Diagnostic Criteria for All Stages of Alzheimer Disease
- May 17, 2011
- Brandy R. Matthews, MD
- Neurology
These criteria emphasize early and preclinical stages of AD and the usefulness of biomarkers.- Reviewing:
- Jack CR Jr et al., Alzheimers Dement 2011 May; 7:257. Sperling RA et al., Alzheimers Dement 2011 May; 7:280. McKhann GM et al., Alzheimers Dement 2011 May; 7:263. Albert MS et al., Alzheimers Dement 2011 May; 7:270.
-
Can We Delay Conversion from Mild Cognitive Impairment to Alzheimer Disease?
- May 16, 2011
- Jonathan Silver, MD
- Psychiatry
Control of vascular risk factors may lower the conversion rate.- Reviewing:
- Li J et al., Neurology 2011 Apr 26; 76:1485.
-
New Genes Associated with Alzheimer Disease
- May 10, 2011
- Brandy R. Matthews, MD
- Neurology
Two large genome-wide association studies revealed at least four new susceptibility loci for AD.- Reviewing:
- Naj AC et al., Nat Genet 2011 May; 43:436. Hollingworth P et al., Nat Genet 2011 May; 43:429.
Sort by:
Items 1 to 20 of 642 results - Relevance
- Date
