From the publishers of The New England Journal of Medicine

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Spotlight

Primary Care

Pediatrics and Adolescent Medicine Supporting Image

First Do No Harm — Avoiding Medication Errors in Children

Medication errors are especially problematic in children because many drugs are formulated for adults.

Specialty Care

Cardiology Supporting Image

Beta-Blockers for Noncardiac Surgery: A Shift in Balance?

Results from the POISE trial suggest that the risks of initiating beta-blockers may outweigh the benefits.

Factor VIIa Not Effective for Intracerebral Hemorrhage

Treatment with rFVIIa was not associated with improved 90-day neurologic outcomes.

Multiple Biomarkers as Predictors of Cardiovascular Death

Four biomarkers, added to traditional risk models, improved prediction of cardiovascular death in older men, but therapeutic implications remain unclear.

Congenital Head and Neck Asymmetry Is Common and Often Unrecognized

Infants with congenital asymmetries might be at increased risk for developing secondary posterior plagiocephaly.

Sleep Duration and Risk for Overweight in Preschoolers

Infants and toddlers who sleep fewer than 12 hours per day have higher risk for being overweight at age 3 years than children who sleep 12 hours or more.

Troponin Levels and Prognosis in Patients with Acute Heart Failure

In an observational study, elevations in cardiac troponin predicted poor outcome — but does routine testing substantially affect treatment decisions?

Cardiovascular Risk Prediction: Beyond the Established Risk Factors

  • Cardiology
  • Summary and Comment
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The inclusion of four biomarkers may improve risk stratification — at least among older men.

Delayed Presentation for ST-Segment-Elevation MI: Which Patients Are at Greatest Risk?

  • Cardiology
  • Summary and Comment
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An analysis of nationwide data profiles the most vulnerable; whether targeted interventions can improve outcomes remains to be seen.

Early Repolarization in Survivors of Idiopathic Ventricular Fibrillation

  • Cardiology
  • Summary and Comment
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In a case-control study, nearly one third of patients who survived sudden cardiac arrest had marked early repolarization.

Surgical Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia

  • Cardiology
  • Summary and Comment
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Sometimes the best treatment is not the newest.

Can Adjustment of Clopidogrel Dosing Reduce Ischemic Events After Stent Implantation?

  • Cardiology
  • Summary and Comment
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In a small but promising trial, adjusting the loading dose according to platelet reactivity improved clinical outcomes.

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