Latest Summaries
Ibrutinib for Marginal Zone Lymphoma
- Michael E. Williams, MD, ScM
Half of patients with relapsed or refractory disease achieved durable responses.
Why Wait? Place That Contraceptive Implant Now
- Diane E. Judge, APN/CNP
Young women had extremely low pregnancy rates whether their implants were placed in accord with package guidelines or on the day of their clinic visit.
Does Binge Eating Always Indicate a Disorder?
- Joel Yager, MD
In a large community survey, nearly half of individuals reporting two or more weekly binge-eating episodes reported no associated distress.
Contraception After Organ Transplantation
- Eleanor Bimla Schwarz, MD, MS
Further data support the safety and effectiveness of intrauterine contraceptives in solid-organ transplant recipients.
“Big Five” Personality Traits Predict Cognitive Impairment and Dementia
- Claire Wilcox, MD
Lower conscientiousness and agreeableness and higher neuroticism were each associated with heightened risks.
How Heritable Are Maladaptive Personality Traits?
- Joel Yager, MD
Maladaptive personality features from the DSM-5's alternative model of personality disorders are about as heritable as the corresponding normative personality factors.
Violent Crime by People with Autism
- Barbara Geller, MD
Conviction rates in Sweden were elevated, but only among those with comorbid attention-deficit/hyperactivity disorder, conduct disorder, substance misuse, or psychosis.
- Enterococcus faecium Transmission at a Single Hospital
- Neil M. Ampel, MD
Whole genome sequencing shows that E. faecium spreads within and between wards as well as between hospitals.
A Negative High-Sensitivity Troponin and Nonischemic ECG Can Rule Out AMI
- Ali S. Raja, MD, MBA, MPH
However, samples for the troponin assay should be drawn at least 3 hours after symptom onset, and a positive troponin does not rule in acute myocardial infarction.
Nivolumab for Advanced Hepatocellular Carcinoma
- David H. Ilson, MD, PhD
In a phase I/II trial, the anti-PD-1 agent had activity in HCC patients regardless of viral status, prior sorafenib exposure, or PD-1 overexpression.
Ketamine Is Effective Adjunct to Morphine for Controlling Acute Pain
- Richard L. Byyny, MD, MSc, FACEP
Morphine plus ketamine performed better than morphine alone in this randomized, double-blind study.
Mumps Outbreak with Complications in Vaccinated Students
- Stephen G. Baum, MD
Fully vaccinated University of Iowa students recently contracted mumps; some developed severe sequelae.
Radiofrequency Ablation vs. Surveillance for Barrett Esophagus with Low-Grade Dysplasia
- David A. Johnson, MD
Rate of progression to high-grade dysplasia or esophageal adenocarcinoma was significantly lower with radiofrequency ablation.
Epidemiology of Adult Meningitis and Encephalitis in the U.S.
- Neil M. Ampel, MD
Although enterovirus and unknown etiology accounted for 70% of hospitalized cases, more than 85% of all patients received an antibacterial.
New Inferior ECG Changes Are Common in Patients with Pulmonary Embolism
- Richard L. Byyny, MD, MSc, FACEP
In a retrospective review of patients newly diagnosed with PE, new electrocardiogram changes were found in the inferior leads in nearly one third of patients.
What Interval Between a Positive Fecal Immunochemical Test and Follow-Up Colonoscopy Is Safe?Free
- Thomas L. Schwenk, MD
No excess risk for colorectal cancer was noted until a delay of 10 months or longer.
Physician Nonadherence to Breast Cancer Screening Guidelines
- Thomas L. Schwenk, MD
Physicians' screening recommendations don't always reflect the guidelines they trust the most.
In-Person Cognitive-Behavioral Therapy vs. Automated Interactive Voice-Response CBT for Chronic Back Pain
- Thomas L. Schwenk, MD
Both approaches provided small but equivalent benefit.
HPV Vaccine: Long-Term Protection After Two Doses
- Deborah Lehman, MD
In girls aged 9 to 13 years, protection at 60 months was equivalent after either two or three doses of HPV vaccine.
Treating Hepatitis C Can Reactivate Hepatitis B
- Stephen G. Baum, MD
Direct-acting antivirals for hepatitis C may cause recrudescence of hepatitis B and lead to mortality in co-infected patients.
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