From the publishers of The New England Journal of Medicine

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Killing in Combat and Suicidal IdeationFree

Veterans who had higher rates of killing in combat are at elevated risk for suicidal thoughts.

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SUMMARY AND COMMENT

Continuous Infusion vs. Intermittent Bolus Dosing of Diuretics in Patients with Heart Failure

A meta-analysis supports continuous infusion of furosemide but does not answer important questions regarding clinical outcomes.

SUMMARY AND COMMENT

Efavirenz Better than Nevirapine for Most PatientsFree

Efavirenz was associated with better outcomes than nevirapine in a large, well-designed cohort analysis of >20,000 patients initiating ART.

SUMMARY AND COMMENT

Once-Daily Darunavir and the Brain

Once-daily dosing of darunavir is associated with lower drug concentrations in the cerebrospinal fluid than twice-daily dosing, but the clinical relevance of this observation remains unclear.

SUMMARY AND COMMENT

Effects of Contemporary ART Regimens on Inflammatory Markers

Certain markers decreased after ART initiation, regardless of regimen, whereas changes in other markers varied by regimen.

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News on HIV and HCV Testing, and in Praise of Accurate Screening TestsFree

Dr. Paul Sax puts the latest news in context in his blog HIV and ID Observations.

SUMMARY AND COMMENT

How Common Are Psychiatric Disorders in Adolescents? How Serious?

Disease prevalence seemed high, but severity was low, in this analysis of a large population-based survey.

SUMMARY AND COMMENT

A Link Between Epilepsy and Psychosis

Epilepsy and psychotic illness co-occur at elevated rates within individuals and within families.

SUMMARY AND COMMENT

Interaction Between SSRIs and NSAIDs? Now It's Missing

Unlike a previous study, this one shows that NSAID use does not affect antidepressant response.

SUMMARY AND COMMENT

A New Model for the Brain System in Major Depression

In patients with major depression, negative information enhances limbic area responses but fails to adequately engage the dorsolateral prefrontal cortex for contextual processing and reappraisal.

SUMMARY AND COMMENT

Rats Behaving Badly: Biological, Transgenerational Transmission of Intimate Partner Violence

Even in the absence of social learning, male rats with violent fathers show aggression toward their female partners.

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